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View Structure Prediction Details

Protein: NetB-PD, NetB-PC...
Organism: Drosophila melanogaster
Length: 793 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NetB-PD, NetB-PC....

Description E-value Query
Range
Subject
Range
LAMA3 - laminin, alpha 3
gi|225000930 - gi|225000930|gb|AAI72580.1| Laminin, alpha 3 [synthetic construct]
374.0 [0..25] [761..31]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRATGTRMG LLLPIILALA IGSSAAGISS NDPCYFEGKP RKCLPSFVNA AYGNPVQASS  60
   61 VCGAQQPERY CELLRDGNAG ECRSCEQQRY GPAALTDLNN PSNVTCWRSG AVNVPHDPDS 120
  121 APPDNVTLTL SLGKKYELTY ISLSFCPRSP RPDSLAIFKS SDFGQTWQPF QFYSSQCQKF 180
  181 Y

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [182-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRPDRAKISK FNEQEARCIN SQHDTGGAAQ RFAFNTLEGR PSANDLDSSL VLQDWVTATD  60
   61 IRVVFHRLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [251-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPQLLKVKN ANAFSDEMGG SREEDEDDDA DLELDGEQDE YDYNLQDNDS ADAGYDEYEE  60
   61 PKKHLELDDD HLHLDYASDG ESVVKRQGKH KGSAYEKHYQ SKLAATTPPQ QPPKVTPPGK 120
  121 VTPPSTAAPS AAASAVTLPI SQHYAVSDFA VGGRCKCNGH ASECVATVSS GSGTALSDQD 180
  181 DGQDEDTPSA PSLAN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.06
Match: 1npeB
Description: Crystal structure of Nidogen/Laminin Complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [446-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFGRSTQMSA KLTMTCACKH NTAGPECERC KPFYFDRPWG RATDNDANEC KMCQCNGHAR  60
   61 RCRFNLELYK LSGRVSGGVC YNCQHDTTGR YCHYCREGYY RDATKPPNHR KVCKRCDCHP 120
  121 VGSTGKTCNH LSGQCPCKEG VTGLTCNRCA RGYQQTRSHV AP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1npeB
Description: Crystal structure of Nidogen/Laminin Complex
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [608-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CIKVPTNANM IQAESAGGGG GGGTGDYKDG GGSQVEEMKK YCGKCKASPK KLNLNKFCME  60
   61 DYAILAKVIG HDRASQDIST EKFSIERQNE IYKYEINIQT IFKRNPMSGT TSSLLGRGNM 120
  121 MLLVPRKSIE CQCPKIKLNK SYLILGRDSE AAPGYLAIGP SSVVLEWKDE WSLRMKRFQR 180
  181 RARKCS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.66
Match: 1uapA
Description: Procollagen c-proteinase enhancer protein PCOLCE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metalloendopeptidase inhibitor activity 2.93008814424574 bayes_pls_golite062009
metalloenzyme regulator activity 2.93008814424574 bayes_pls_golite062009
metalloenzyme inhibitor activity 2.93008814424574 bayes_pls_golite062009
cytokine activity 2.1026057983858 bayes_pls_golite062009
protein binding 1.99085018021326 bayes_pls_golite062009
chemokine activity 1.91192407750516 bayes_pls_golite062009
chemokine receptor binding 1.91192407750516 bayes_pls_golite062009
receptor binding 1.70988428101653 bayes_pls_golite062009
binding 1.55301582466033 bayes_pls_golite062009
G-protein-coupled receptor binding 1.33224850209979 bayes_pls_golite062009
endopeptidase inhibitor activity 1.31068274422963 bayes_pls_golite062009
peptidase inhibitor activity 1.26079752095237 bayes_pls_golite062009
enzyme inhibitor activity 1.2236133281236 bayes_pls_golite062009
integrin binding 0.387338090721027 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle