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View Structure Prediction Details

Protein: NetB-PD, NetB-PC...
Organism: Drosophila melanogaster
Length: 793 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NetB-PD, NetB-PC....

Description E-value Query
Range
Subject
Range
LAMA3 - laminin, alpha 3
gi|225000930 - gi|225000930|gb|AAI72580.1| Laminin, alpha 3 [synthetic construct]
374.0 [0..25] [761..31]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRATGTRMG LLLPIILALA IGSSAAGISS NDPCYFEGKP RKCLPSFVNA AYGNPVQASS  60
   61 VCGAQQPERY CELLRDGNAG ECRSCEQQRY GPAALTDLNN PSNVTCWRSG AVNVPHDPDS 120
  121 APPDNVTLTL SLGKKYELTY ISLSFCPRSP RPDSLAIFKS SDFGQTWQPF QFYSSQCQKF 180
  181 Y

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [182-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRPDRAKISK FNEQEARCIN SQHDTGGAAQ RFAFNTLEGR PSANDLDSSL VLQDWVTATD  60
   61 IRVVFHRLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [251-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPQLLKVKN ANAFSDEMGG SREEDEDDDA DLELDGEQDE YDYNLQDNDS ADAGYDEYEE  60
   61 PKKHLELDDD HLHLDYASDG ESVVKRQGKH KGSAYEKHYQ SKLAATTPPQ QPPKVTPPGK 120
  121 VTPPSTAAPS AAASAVTLPI SQHYAVSDFA VGGRCKCNGH ASECVATVSS GSGTALSDQD 180
  181 DGQDEDTPSA PSLAN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.06
Match: 1npeB
Description: Crystal structure of Nidogen/Laminin Complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [446-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFGRSTQMSA KLTMTCACKH NTAGPECERC KPFYFDRPWG RATDNDANEC KMCQCNGHAR  60
   61 RCRFNLELYK LSGRVSGGVC YNCQHDTTGR YCHYCREGYY RDATKPPNHR KVCKRCDCHP 120
  121 VGSTGKTCNH LSGQCPCKEG VTGLTCNRCA RGYQQTRSHV AP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1npeB
Description: Crystal structure of Nidogen/Laminin Complex
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [608-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CIKVPTNANM IQAESAGGGG GGGTGDYKDG GGSQVEEMKK YCGKCKASPK KLNLNKFCME  60
   61 DYAILAKVIG HDRASQDIST EKFSIERQNE IYKYEINIQT IFKRNPMSGT TSSLLGRGNM 120
  121 MLLVPRKSIE CQCPKIKLNK SYLILGRDSE AAPGYLAIGP SSVVLEWKDE WSLRMKRFQR 180
  181 RARKCS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.66
Match: 1uapA
Description: Procollagen c-proteinase enhancer protein PCOLCE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metalloendopeptidase inhibitor activity 2.93008814424574 bayes_pls_golite062009
metalloenzyme regulator activity 2.93008814424574 bayes_pls_golite062009
metalloenzyme inhibitor activity 2.93008814424574 bayes_pls_golite062009
cytokine activity 2.1026057983858 bayes_pls_golite062009
protein binding 1.99085018021326 bayes_pls_golite062009
chemokine activity 1.91192407750516 bayes_pls_golite062009
chemokine receptor binding 1.91192407750516 bayes_pls_golite062009
receptor binding 1.70988428101653 bayes_pls_golite062009
binding 1.55301582466033 bayes_pls_golite062009
G-protein-coupled receptor binding 1.33224850209979 bayes_pls_golite062009
endopeptidase inhibitor activity 1.31068274422963 bayes_pls_golite062009
peptidase inhibitor activity 1.26079752095237 bayes_pls_golite062009
enzyme inhibitor activity 1.2236133281236 bayes_pls_golite062009
integrin binding 0.387338090721027 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle