YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Lig4-PA

General Information:
Name(s) found: Lig4-PA / FBpp0073678 [FlyBase]
Description(s) found:
Found 20 descriptions.
SHOW ALL
  • The gene Ligase4 is referred to in FlyBase by the symbol Dmel\Lig4 (CG12176, FBgn0030506). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13558617..13561841. It has the cytological map location 12B2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: telomere maintenance; response to ionizing radiation; double-strand break repair via nonhomologous end joining. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 918 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: DNA replication [IEA]
    DNA recombination [IEA]
    telomere maintenance [IGI]
    double-strand break repair via nonhomologous end joining [IMP]
    response to ionizing radiation [IMP]
    Molecular Function: ATP binding [IEA]
    DNA binding [IEA]
    DNA ligase (ATP) activity [ISS]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVDIASTIK FRDICSLFEK IKATQKVANK EEVLKSYYES FCRHRESFRR QTGLNNDQPE  60
   61 DGASSFYSVL RLLLPGADTG RDTYGLQITA LGRLYIRVLQ LPTDSSDAIR LQHRNGNMYR 120
  121 DYGDVVYSVL KPRCFNPPSN LRLKEIHQML DTIANEDTEV KQQQLIRFTE QASPEEQKWL 180
  181 IRLLLKSLGL GIGEQKIFGV LHPKAQDIYQ RCSDLGHVCN LLADRTTDLD ASSSKDSKAA 240
  241 VKFVNLNSVI RPFHQIRPML CERFPGDIQE LMQSDVLYLE TKMDGERFQL HIDRGRFMYI 300
  301 SRNGVDYTRN FGHSYDHGTL TPKLRGLLPL GLESIILDGE MMVWDTNKLR FREKGENTDV 360
  361 KSLKPEGSWQ PCFVVYDLLY FNGQSLLDHT YIQRAYKLQK LIVEQSGVLQ LMRARKIGSV 420
  421 QEFNELFQQA LDSHAEGIVL KKQGSRYQPG VRLGGGWYKD KADYIKGLIT EFDVLIIGAF 480
  481 YNRKRTFVDS FLLGVLQPAP PGSSNRPEVF SIGVVANNTK QRGVLNHTLK PHWHDVVNEP 540
  541 PPLWFHYKPK ERSGCPDLWI EPQNSVILQV KAADLAPNGA FFTRKSLHFP RTEMKRDDKT 600
  601 WSECMTLKEF NDLCGGPLAI KKLNKRQLRL EDVTTKRKQM RMTPSERSRL GLAVYEKRYD 660
  661 ASTSASTSKL FDGLSFCILS GSAGRHSKHQ LQELAVKNGG CIVENPLPND PKCFCIAGDE 720
  721 TFLVKRLILQ QPRTCDIVRM EWLLRVCQKQ ELELKPRDLI AATEPLQQDL AECFDRHGDS 780
  781 YTKDIANVEE LQDLLQGIEL TADNVAGITA SNLNALEDQL LDGKKNLNMF RNLNAFFYSP 840
  841 HGDEVAKLLF LQNGGRIVDD SDPQLNLGFI CMSSDIDNDH FEHWLHNHSK LTTDKVLNSA 900
  901 WIHQCHREGI LLPMHSFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..665] PSI-BLAST 123.0 Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
    2 View Details [666..918] PSI-BLAST 29.69897 Co-Crystal Structure of Lif1p-Lig4p

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA ligase activity
    		•  10.0279903057926 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  9.92846900587219 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  8.51283882444113 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  3.17397926295565 bayes_pls_golite062009
  • ligase activity
    		•  2.36807839237461 bayes_pls_golite062009
  • catalytic activity
    		•  2.15370807854636 bayes_pls_golite062009
  • binding
    		•  1.82998145778732 bayes_pls_golite062009
  • protein binding
    		•  1.38006517521813 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.06318697852063 bayes_pls_golite062009
  • DNA binding
    		•  0.920391596538289 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle