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Protein Overview: LIMK1-PC

General Information:
Name(s) found: LIMK1-PC / FBpp0073493 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene LIM-kinase1 is referred to in FlyBase by the symbol Dmel\LIMK1 (CG1848, FBgn0041203). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12478418..12486226. It has the cytological map location 11B2. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: synapse assembly; regulation of axonogenesis; compound eye development; establishment of planar polarity; establishment of imaginal disc-derived wing hair orientation; protein amino acid phosphorylation; synaptic growth at neuromuscular junction. 16 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; organ system; multi-cell-component structure; nervous system; thoracic segment; antennal segment; adult mesothoracic segment; adult brain; appendage segment; mushroom body. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1257 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: synapse assembly [IMP]
    synaptic growth at neuromuscular junction [IMP]
    regulation of axonogenesis [IMP]
    establishment of planar polarity [IMP]
    establishment of imaginal disc-derived wing hair orientation [IMP]
    protein amino acid phosphorylation [IDA][NAS]
    actin cytoskeleton organization [NAS]
    compound eye development [IGI]
    Molecular Function: ATP binding [IEA]
    zinc ion binding [IEA]
    protein binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHHQQRLRAN GGRGGTGLGA GSGPVSGGHS PLCAHCRGQL LPHPEEPIVM ALGQQWHCDC  60
   61 FRCSVCEGHL HNWYFEREGL LYCREDYYGR FGDACQQCMA VITGPVMVAG EHKFHPECFC 120
  121 CTACGSFIGE GESYALVERS KLYCGQCYGK RSCQPADAKA RITTAGKPMH SIRLVEIPKD 180
  181 ATPGLRVDGV ALDDGCPTVR ITDLFCNFFL WLTSMAEQCC GAPYRIDVNL TNLHIGDRIL 240
  241 EVNGTPVSDS SVEQIDKLIR SNEKMLQLTV EHDPVQVCRS CSQADIQRAM SASTLILPLS 300
  301 TSASSVEVGR ERLYKTPGEQ GTKARKLRQA TNASTTIPPA AGATAMTQLK EKERCSSLSK 360
  361 LLDEQHQAQQ HSAHPQLYDL SRTQSCRVVQ KPQRIFRATD LVIGEKLGEG FFGKVFKVTH 420
  421 RQSGEVMVLK ELHRADEEAQ RNFIKEVAVL RLLDHRHVLK FIGVLYKDKK LHMVTEYVAG 480
  481 GCLKELIHDP AQVLPWPQRV RLARDIACGM SYLHSMNIIH RDLNSMNCLV REDRSVIVAD 540
  541 FGLARSVDAP RLPSGNMTPG GYGSGANSDA PMSPSGTLRR SKSRQRRQRY TVVGNPYWMA 600
  601 PEMMKGLKYD EKVDVFSFGI MLCEIIGRVE ADPDFMPRNS DFSLNQQEFR EKFCAQCPEP 660
  661 FVKVAFVCCD LNPDMRPCFE TLHVWLQRLA DDLAADRVPP ERLLHEIETF QEWYASSEDA 720
  721 LSPTSQRSLN NLDELVKSAV DSEISPVEKE KENMVIKPQD IPKSPHLGKD FSPSGERLRD 780
  781 SMRARRRQRF LGAQEERRNL TPDTESKERA LKKALKKCRP FGERGYLVDL RAGAELQLED 840
  841 VRDLNTYSDV DSSCDTSLNY HDVNNLPAAQ EDENTVKPGK EELLEESTNK PSNQESQHHR 900
  901 LAIDDMRTRL NQCRSKFEHL EEASRRNFNQ SQHSMKNFFK TPPVALKMFQ RLEHEAAALN 960
  961 GGNNCPPPPP RTQRINQTPI FGRKNPPVAI VGQKLQHAES LEDLASSGVA KQLATPAPKR1020
 1021 SKATATTKGG QSSNPPLFLP PSLNISVALN SNGNVTTTTN TNSSCPPSAS DWLPKKHKLT1080
 1081 LPLPSAQQQR TSSNHRLPMC NNKGKTLKPL PSRTGSQGIP ASNCVSPTRS SRPGSPTKHL1140
 1141 AQRHTAATAQ RLTNAAATHQ QQHQQQSSKT TRLNILSPEK VHRLGARLTD QKQKMREEAA1200
 1201 ATASSVGGAG CAAGTAAGSL NGHRTIGSSG TPNSAVGERR RRAAPSPPVR THFNTRC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] FFAS03 2.82 Cysteine-rich (intestinal) protein, CRP, CRIP
    2 View Details [98..148] PSI-BLAST 9.30103 Solution structures of the second LIM domain of human LIM-kinase 2 (LIMK2)
    3 View Details [149..291] FFAS03 4.04 Solution Structure of RSGI RUH-003, a PDZ domain of hypothetical KIAA0559 protein from human cDNA
    4 View Details [292..349] PSI-BLAST 77.30103 CHICKEN SRC TYROSINE KINASE
    5 View Details [350..634] PSI-BLAST 19.69897 No description for 2pziA was found.
    6 View Details [635..699] FFAS03 3.79 Vascular endothelial growth factor receptor 2 (kdr)
    7 View Details [700..771] PSI-BLAST 58.30103 Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
    8 View Details [772..839] deduced N/A No confident structure predictions are available.
    9 View Details [840..1257] PSI-BLAST 3.69897 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.16757861573985 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.62296162642478 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.46727132249624 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.86972157198727 bayes_pls_golite062009
  • signal transducer activity
    		•  1.86972157198727 bayes_pls_golite062009
  • receptor activity
    		•  1.84800188265901 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.59407701118798 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.50210964370113 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.30969036945023 bayes_pls_golite062009
  • transporter activity
    		•  1.29143782009237 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.26313925559554 bayes_pls_golite062009
  • actin binding
    		•  1.25913398970028 bayes_pls_golite062009
  • structural molecule activity
    		•  1.1947100233139 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07067346221546 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801223278704275 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.68270103300828 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.61572149323953 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.256420113528322 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.139330227283617 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
  • actin filament binding
    		•  0.0796070976754208 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  3.22145158985802 bayes_pls_golite062009
  • binding
    		•  3.13429174152905 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47765278304147 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.45866144250133 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.19213139019759 bayes_pls_golite062009
  • actin binding
    		•  1.75180812110908 bayes_pls_golite062009
  • kinase activity
    		•  1.61912794142819 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.45002278548532 bayes_pls_golite062009
  • transcription activator activity
    		•  1.36622358043184 bayes_pls_golite062009
  • transporter activity
    		•  1.20918305129892 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08101408526167 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07511371892473 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07511371892473 bayes_pls_golite062009
  • transferase activity
    		•  1.07041634627158 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.884059816912259 bayes_pls_golite062009
  • structural molecule activity
    		•  0.859062040528963 bayes_pls_golite062009
  • receptor binding
    		•  0.771579763169856 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.768438717123608 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.536084024887128 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.528433788391959 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.412972149823917 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.401359285032961 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260876923856991 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.182955958442811 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.144584642425267 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.114526798255133 bayes_pls_golite062009
  • actin filament binding
    		•  0.0938795699417794 bayes_pls_golite062009
  • transcription factor binding
    		•  0.00645857102266056 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle