| Protein: | LIMK1-PC |
| Organism: | Drosophila melanogaster |
| Length: | 1257 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LIMK1-PC.
| Description | E-value | Query Range |
Subject Range |
|
|
607.0 | [0..1] | [1257..1] |
|
Region A: Residues: [1-97] |
1 11 21 31 41 51
| | | | | |
1 MHHQQRLRAN GGRGGTGLGA GSGPVSGGHS PLCAHCRGQL LPHPEEPIVM ALGQQWHCDC 60
61 FRCSVCEGHL HNWYFEREGL LYCREDYYGR FGDACQQ
|
| Detection Method: |  |
| Confidence: | 2.82 |
| Match: | 1cxxA |
| Description: | Cysteine-rich (intestinal) protein, CRP, CRIP |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [98-148] |
1 11 21 31 41 51
| | | | | |
1 CMAVITGPVM VAGEHKFHPE CFCCTACGSF IGEGESYALV ERSKLYCGQC Y
|
| Detection Method: | |
| Confidence: | 9.30103 |
| Match: | 1x6aA |
| Description: | Solution structures of the second LIM domain of human LIM-kinase 2 (LIMK2) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 4.00967542385368 | bayes_pls_golite062009 |
| DNA binding | 3.60745514727532 | bayes_pls_golite062009 |
| nucleic acid binding | 3.16757861573985 | bayes_pls_golite062009 |
| binding | 2.96409924710655 | bayes_pls_golite062009 |
| transcription activator activity | 2.9532663930699 | bayes_pls_golite062009 |
| transcription factor activity | 2.90769972671972 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.72967350701574 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.62296162642478 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.46727132249624 | bayes_pls_golite062009 |
| protein binding | 2.44501340584871 | bayes_pls_golite062009 |
| molecular transducer activity | 1.86972157198727 | bayes_pls_golite062009 |
| signal transducer activity | 1.86972157198727 | bayes_pls_golite062009 |
| receptor activity | 1.84800188265901 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.59407701118798 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.50210964370113 | bayes_pls_golite062009 |
| ligand-dependent nuclear receptor activity | 1.49515149729803 | bayes_pls_golite062009 |
| transcription factor binding | 1.38523780690867 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.30969036945023 | bayes_pls_golite062009 |
| transporter activity | 1.29143782009237 | bayes_pls_golite062009 |
| structural constituent of ribosome | 1.26313925559554 | bayes_pls_golite062009 |
| actin binding | 1.25913398970028 | bayes_pls_golite062009 |
| structural molecule activity | 1.1947100233139 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.07067346221546 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.801223278704275 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 0.68270103300828 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.61572149323953 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.58115018700114 | bayes_pls_golite062009 |
| transcription repressor activity | 0.256420113528322 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.139330227283617 | bayes_pls_golite062009 |
| catalytic activity | 0.101795606736461 | bayes_pls_golite062009 |
| actin filament binding | 0.0796070976754208 | bayes_pls_golite062009 |
|
Region A: Residues: [149-291] |
1 11 21 31 41 51
| | | | | |
1 GKRSCQPADA KARITTAGKP MHSIRLVEIP KDATPGLRVD GVALDDGCPT VRITDLFCNF 60
61 FLWLTSMAEQ CCGAPYRIDV NLTNLHIGDR ILEVNGTPVS DSSVEQIDKL IRSNEKMLQL 120
121 TVEHDPVQVC RSCSQADIQR AMS
|
| Detection Method: | |
| Confidence: | 4.04 |
| Match: | 1ujdA |
| Description: | Solution Structure of RSGI RUH-003, a PDZ domain of hypothetical KIAA0559 protein from human cDNA |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein binding | 3.22145158985802 | bayes_pls_golite062009 |
| binding | 3.13429174152905 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.47765278304147 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.45866144250133 | bayes_pls_golite062009 |
| transcription regulator activity | 2.19213139019759 | bayes_pls_golite062009 |
| actin binding | 1.75180812110908 | bayes_pls_golite062009 |
| kinase activity | 1.61912794142819 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.45002278548532 | bayes_pls_golite062009 |
| transcription activator activity | 1.36622358043184 | bayes_pls_golite062009 |
| transporter activity | 1.20918305129892 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.08101408526167 | bayes_pls_golite062009 |
| molecular transducer activity | 1.07511371892473 | bayes_pls_golite062009 |
| signal transducer activity | 1.07511371892473 | bayes_pls_golite062009 |
| transferase activity | 1.07041634627158 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.884059816912259 | bayes_pls_golite062009 |
| structural molecule activity | 0.859062040528963 | bayes_pls_golite062009 |
| receptor binding | 0.771579763169856 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.768438717123608 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.536084024887128 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.528433788391959 | bayes_pls_golite062009 |
| protein domain specific binding | 0.412972149823917 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.401359285032961 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.260876923856991 | bayes_pls_golite062009 |
| small GTPase regulator activity | 0.182955958442811 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 0.144584642425267 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.114526798255133 | bayes_pls_golite062009 |
| actin filament binding | 0.0938795699417794 | bayes_pls_golite062009 |
| transcription factor binding | 0.00645857102266056 | bayes_pls_golite062009 |
|
Region A: Residues: [292-349] |
1 11 21 31 41 51
| | | | | |
1 ASTLILPLST SASSVEVGRE RLYKTPGEQG TKARKLRQAT NASTTIPPAA GATAMTQL
|
| Detection Method: | |
| Confidence: | 77.30103 |
| Match: | 2ptkA |
| Description: | CHICKEN SRC TYROSINE KINASE |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [350-634] |
1 11 21 31 41 51
| | | | | |
1 KEKERCSSLS KLLDEQHQAQ QHSAHPQLYD LSRTQSCRVV QKPQRIFRAT DLVIGEKLGE 60
61 GFFGKVFKVT HRQSGEVMVL KELHRADEEA QRNFIKEVAV LRLLDHRHVL KFIGVLYKDK 120
121 KLHMVTEYVA GGCLKELIHD PAQVLPWPQR VRLARDIACG MSYLHSMNII HRDLNSMNCL 180
181 VREDRSVIVA DFGLARSVDA PRLPSGNMTP GGYGSGANSD APMSPSGTLR RSKSRQRRQR 240
241 YTVVGNPYWM APEMMKGLKY DEKVDVFSFG IMLCEIIGRV EADPD
|
| Detection Method: | |
| Confidence: | 19.69897 |
| Match: | 2pziA |
| Description: | No description for 2pziA was found. |
|
Region A: Residues: [635-699] |
1 11 21 31 41 51
| | | | | |
1 FMPRNSDFSL NQQEFREKFC AQCPEPFVKV AFVCCDLNPD MRPCFETLHV WLQRLADDLA 60
61 ADRVP
|
| Detection Method: | |
| Confidence: | 3.79 |
| Match: | 1vr2A |
| Description: | Vascular endothelial growth factor receptor 2 (kdr) |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [700-771] |
1 11 21 31 41 51
| | | | | |
1 PERLLHEIET FQEWYASSED ALSPTSQRSL NNLDELVKSA VDSEISPVEK EKENMVIKPQ 60
61 DIPKSPHLGK DF
|
| Detection Method: | |
| Confidence: | 58.30103 |
| Match: | 1xjdA |
| Description: | Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [772-839] |
1 11 21 31 41 51
| | | | | |
1 SPSGERLRDS MRARRRQRFL GAQEERRNLT PDTESKERAL KKALKKCRPF GERGYLVDLR 60
61 AGAELQLE
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [840-1257] |
1 11 21 31 41 51
| | | | | |
1 DVRDLNTYSD VDSSCDTSLN YHDVNNLPAA QEDENTVKPG KEELLEESTN KPSNQESQHH 60
61 RLAIDDMRTR LNQCRSKFEH LEEASRRNFN QSQHSMKNFF KTPPVALKMF QRLEHEAAAL 120
121 NGGNNCPPPP PRTQRINQTP IFGRKNPPVA IVGQKLQHAE SLEDLASSGV AKQLATPAPK 180
181 RSKATATTKG GQSSNPPLFL PPSLNISVAL NSNGNVTTTT NTNSSCPPSA SDWLPKKHKL 240
241 TLPLPSAQQQ RTSSNHRLPM CNNKGKTLKP LPSRTGSQGI PASNCVSPTR SSRPGSPTKH 300
301 LAQRHTAATA QRLTNAAATH QQQHQQQSSK TTRLNILSPE KVHRLGARLT DQKQKMREEA 360
361 AATASSVGGA GCAAGTAAGS LNGHRTIGSS GTPNSAVGER RRRAAPSPPV RTHFNTRC
|
| Detection Method: | |
| Confidence: | 3.69897 |
| Match: | 1y0fA |
| Description: | No description for 1y0fA was found. |
