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Protein Overview: Rab40-PB

General Information:
Name(s) found: Rab40-PB / FBpp0073502 [FlyBase]
Description(s) found:
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  • gi|54650586|gb|AAV36872.1| RE54550p [Drosophila melanogaster] [NCBI NR]
  • gi|24641535|ref|NP_727611.1| Rab40, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|22832135|gb|AAN09309.1| Rab40, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene Rab40 is referred to in FlyBase by the symbol Dmel\Rab40 (CG1900, FBgn0030391). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12353823..12357141. It has the cytological map location 11A11. Based on sequence similarity, it is predicted to have molecular function</span>: GTPase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG1900-PB translation from_gene[CG1900 CG1900 FBgn0030391] seq_release:3 mol_weight=29759 cds_boundaries:(X:12,191,029..12,192,528[-]) aa_length:265 transcript_info:[CG1900-RB seq_release:3] gene_info:[gene symbol:CG1900 FBgn0030391 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8IR80) CG1900-PB [DrosMelano7227.FASTAC.txt]
  • CG1900-PB, isoform B [Drosophila melanogaster]gi|54650586|gb|AAV36872.1| RE54550p [Drosophila melanogaster]gi|24641535|ref|NP_727611.1| CG1900-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(12354399..12354616,12355022..12355244,12355489..12355712,12355769..12355901); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,R [fly-100309-contam.fasta]
  • Rab40 CG1900-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1900-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE54550p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(12354399..12354616,12355022..12355244,12355489..12355712,12355769..12355901); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,REFSEQ:NP_727611,GB_protein:AAN09309; MD5=859466e91084fc7bfd7e0740bb4b0e21; length=265; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(12354399..12354616,12355022..12355244,12355489..12355712,12355769..12355901); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,REFSEQ:NP_727611,GB_protein:AAN09309; MD5=859466e91084fc7bfd7e0740bb4b0e21; length=265; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • RE54550p OS=Drosophila melanogaster GN=Rab40 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(12354399..12354616,12355022..12355244,12355489..12355712,12355769..12355901); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,REFSEQ:NP_727611,GB_protein:AAN09309,FlyMine:FBpp0073502,modMine:FBpp0073502; MD5=859466e91084fc7bfd7e0740bb4b0e21; length=265; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(12461736..12461868,12461456..12461679,12460989..12461211,12460366..12460583)); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,REFSEQ:NP_727611,GB_protein:AAN09309,FlyMine:FBpp0073502,modMine:FBpp0073502; MD5=859466e91084fc7bfd7e0740bb4b0e21; length=265; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(12461736..12461868,12461456..12461679,12460989..12461211,12460366..12460583)); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,REFSEQ:NP_727611,GB_protein:AAN09309,FlyMine:FBpp0073502,modMine:FBpp0073502; MD5=859466e91084fc7bfd7e0740bb4b0e21; length=265; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0073502 type=protein; loc=X:complement(join(12461736..12461868,12461456..12461679,12460989..12461211,12460366..12460583)); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,REFSEQ:NP_727611,GB_protein:AAN09309,FlyMine:FBpp0073502,modMine:FBpp0073502; MD5=859466e91084fc7bfd7e0740bb4b0e21; length=265; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(12461736..12461868,12461456..12461679,12460989..12461211,12460366..12460583)); ID=FBpp0073502; name=Rab40-PB; parent=FBgn0030391,FBtr0073669; dbxref=FlyBase:FBpp0073502,FlyBase_Annotation_IDs:CG1900-PB,GB_protein:AAN09309.1,REFSEQ:NP_727611,GB_protein:AAN09309,UniProt/TrEMBL:Q8IR80,FlyMine:FBpp0073502,modMine:FBpp0073502; MD5=859466e91084fc7bfd7e0740bb4b0e21; length=265; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 265 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of cell shape [IMP]
    small GTPase mediated signal transduction [IEA]
    protein transport [IEA]
    Molecular Function: GTP binding [IEA]
    GTPase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTMTKDYDY LLKVLLVGDS DVGKHEILSN LEDPSTESPF CSGNDCTSHI LQTVAYKTTT  60
   61 ILLEGKRVKL QLWDTSGQGR FCTIIRSYSR GAQGIILVYD ITNKWSFDGI DRWLKEVDEH 120
  121 APGIPKVLVG NRLHLAFKRQ VAAKQAETYA SRNNMSCFEI SPLCNFNIRE SFCELARMAL 180
  181 HRNGMEHIWR SNKVLSLQEL CCRTIVRRTS VYAIDSLPLP PSVKSTLKSY ALTTSQCFNS 240
  241 LTQSSKSKNR CKTPTSSSRN SCAIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..265] PSI-BLAST 52.69897 Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTPase activity
    		•  4.52394549632777 bayes_pls_golite062009
  • microtubule motor activity
    		•  4.51968578934603 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.89122312915795 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.81593838944939 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.79724985811732 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.79347973548337 bayes_pls_golite062009
  • hydrolase activity
    		•  2.73675310079844 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.51786963027655 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity
    		•  2.44176688200537 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • actin binding
    		•  2.2973522188675 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  1.95782378818812 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • signal recognition particle binding
    		•  1.46975774710831 bayes_pls_golite062009
  • antigen binding
    		•  1.43656260286121 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  1.38366133153678 bayes_pls_golite062009
  • actin filament binding
    		•  1.28204719195916 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ATP binding
    		•  0.98146619596929 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.949788783884952 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.931486373329219 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.92105578610354 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.901460716954519 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.876296121718575 bayes_pls_golite062009
  • kinase activity
    		•  0.691112783105676 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.63002958837536 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.53788302029845 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.499834566483656 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • receptor binding
    		•  0.309955875731734 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0430764033739892 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0364322017534667 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle