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Protein Overview: FBpp0310241, PhK...

General Information:
Name(s) found: FBpp0310241 [FlyBase]
PhKgamma-PB / FBpp0089045 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=X:join(11590482..11590573,11591099..11591277,11591344..11591628,11591694..11591784,11592332..11592468,11592533..11592630,11593356..11593439,11597323..11597481,11597542..11597676); ID=FBpp0310241; name=PhKgamma-PH; parent=FBgn0011754,FBtr0343648; dbxref=FlyBase:FBpp0310241,FlyBase_Annotation_IDs:CG1830-PH; MD5=40e643613d392b1ba48a015c7baf0a3c; length=419; release=r5.56; species=Dmel; [FlyBase]
  • The gene Phosphorylase kinase Ã?&#142;Ã?³ is referred to in FlyBase by the symbol Dmel\PhKÃ?&#142;Ã?³ (CG1830, FBgn0011754). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11589145..11598427. It has the cytological map location 10D5. Based on sequence similarity, it is predicted to have molecular function</span>: phosphorylase kinase activity. There is experimental evidence that it is involved in the biological process</span>: embryonic morphogenesis. 16 alleles are reported. The phenotypes of these alleles are annotated with: leg; cuticle; femur; joint; tibia. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 419 amino acids

    Gene Ontology:
    Cellular Component: phosphorylase kinase complex [IEA][ISS]
    Biological Process: glycogen biosynthetic process [IEA]
    embryonic morphogenesis [IMP]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    glucose catabolic process [ISS]
    Molecular Function: phosphorylase kinase activity [IEA][ISS]
    ATP binding [IEA]
    calmodulin binding [IEA]
    protein serine/threonine kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKDEEDDLL PDKDAAKGFY AKYEPKEILG RGISSTVRRC IEKETGKEFA AKIIDLGATT  60
   61 ESGETNPYHM LEATRQEISI LRQVMGHPYI IDLQDVFESD AFVFLVFELC PKGELFDYLT 120
  121 SVVTLSEKKT RTIMRQIFEG VEYIHAKSIV HRDLKPENIL LDENHNVKIT DFGFAKQLQE 180
  181 GEKLTNLCGT PGYLAPETLK CNMFEGSPGY SQEVDIWACG VIMFTLLVGC PPFWHRKQMV 240
  241 MLRNIMEGKY SFTSPEWADI SEDPKDLIRK CLVVDPSQRI TVKEVLRHPF FNQMLFEQNI 300
  301 DGLKRSLSTK SRRMSRITEI ALLRKQSRFN ARKKFQFAIL VIRAIIRIRR LRFTAEPLHV 360
  361 EEAIRDPYRV KVLRKVIDGC AFRVYGHWVK KGEGQNRAAL FENTPRTELH ALYINNLSR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..298] PSI-BLAST 71.69897 gamma-subunit of glycogen phosphorylase kinase (Phk)
    2 View Details [299..419] PSI-BLAST 8.69897 Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • phosphorylase kinase activity
    		•  4.23570595363447 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.47162554695064 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.0795689006739899 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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