Protein Overview: dsh-PA

General Information:
Name(s) found:	dsh-PA / FBpp0073310 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7292634\|gb\|AAF48033.1\| dishevelled, isoform A [Drosophila melanogaster] [NCBI NR] gi\|71834235\|gb\|AAZ41790.1\| LD20984p [Drosophila melanogaster] [NCBI NR] gi\|68067469\|sp\|P51140.2\|DSH_DROME RecName: Full=Segment polarity protein dishevelled [NCBI NR] gi\|24641268\|ref\|NP_511118.2\| dishevelled, isoform A [Drosophila melanogaster] [NCBI NR] Segment polarity protein dishevelled OS=Drosophila melanogaster GN=dsh PE=1 SV=2 [Swiss-Prot] The gene dishevelled is referred to in FlyBase by the symbol Dmel\dsh (CG18361, FBgn0000499). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11249914..11252759. It has the cytological map location 10B4-10B5. There is experimental evidence that it has the molecular function</span>: phosphatidic acid binding. There is experimental evidence for 20 unique biological process</span> terms, many of which group under: anatomical structure development; organ morphogenesis; cell projection organization; regulation of developmental process; reproductive process in a multicellular organism; sensory organ development; establishment of planar polarity; imaginal disc-derived wing hair organization; cell projection assembly; multicellular organism reproduction. 107 alleles are reported. The phenotypes of these alleles are annotated with 65 unique terms, many of which group under: adult segment; organ system; peripheral nervous system; abdominal ventral denticle belt; nervous system; external compound sense organ; adult mesothoracic segment; embryonic nervous system; larval abdominal segment; metatarsus. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG18361-PA translation from_gene[CG18361 dsh FBgn0000499] seq_release:3 mol_weight=68918 cds_boundaries:(X:11,098,293..11,100,161[+]) aa_length:623 transcript_info:[CG18361-RA seq_release:3] gene_info:[gene symbol:dsh synonyms:[CG1720] FBgn0000499 gen [hmr_yeast5_DM3-1_pombe.fasta] (Q9VYZ9) DSH protein [DrosMelano7227.FASTAC.txt] (AE003485) CG18361 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG18361-PA, isoform A [Drosophila melanogaster]gi\|24641268\|ref\|NP_511118.2\| CG18361-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=X:11250387..11252258; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033; MD5=db4e264e3e0e4b081000a7b8e3492 [fly-100309-contam.fasta] LD20984p [Drosophila melanogaster] [nr-271106-contam.fasta] CG18361-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] dishevelled CG18361-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Segment polarity protein dishevelled [nr-271106-contam.fasta] type=protein; loc=X:11250387..11252258; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033; MD5=db4e264e3e0e4b081000a7b8e3492a49; length=623; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:11250387..11252258; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033; MD5=db4e264e3e0e4b081000a7b8e3492a49; length=623; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=X:11250387..11252258; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033,FlyMine:FBpp0073310,modMine:FBpp0073310; MD5=db4e264e3e0e4b081000a7b8e3492a49; length=623; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:11356354..11358225; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033,FlyMine:FBpp0073310,modMine:FBpp0073310; MD5=db4e264e3e0e4b081000a7b8e3492a49; length=623; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:11356354..11358225; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033,FlyMine:FBpp0073310,modMine:FBpp0073310; MD5=db4e264e3e0e4b081000a7b8e3492a49; length=623; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0073310 type=protein; loc=X:11356354..11358225; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033,FlyMine:FBpp0073310,modMine:FBpp0073310; MD5=db4e264e3e0e4b081000a7b8e3492a49; length=623; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:11356354..11358225; ID=FBpp0073310; name=dsh-PA; parent=FBgn0000499,FBtr0073454; dbxref=FlyBase:FBpp0073310,FlyBase_Annotation_IDs:CG18361-PA,GB_protein:AAF48033.1,REFSEQ:NP_511118,GB_protein:AAF48033,UniProt/Swiss-Prot:P51140,FlyMine:FBpp0073310,modMine:FBpp0073310; MD5=db4e264e3e0e4b081000a7b8e3492a49; length=623; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	623 amino acids
Gene Ontology:
Cellular Component:	adherens junction [TAS] cytoplasm [NAS][TAS] intracellular [IEA] plasma membrane [IDA]
Biological Process:	dorsal closure [IMP][TAS] regulation of actin filament bundle assembly [IGI] dorsal closure, elongation of leading edge cells [IMP] imaginal disc-derived wing morphogenesis [IMP][TAS] protein localization [TAS] female gonad development [IMP] salivary gland morphogenesis [IMP] heart development [NAS][TAS] compound eye morphogenesis [IMP] ovarian follicle cell development [IMP] establishment of epithelial cell apical/basal polarity [IMP] somatic stem cell maintenance [IMP] Wnt receptor signaling pathway [NAS][TAS] imaginal disc-derived wing hair organization [IGI][IMP] ommatidial rotation [NAS] establishment of tissue polarity [NAS][TAS] establishment or maintenance of cell polarity [NAS] establishment of ommatidial planar polarity [IGI][IMP] establishment of body bristle planar orientation [TAS] R3/R4 cell fate commitment [NAS] filopodium assembly [IMP] sensory organ development [NAS] regulation of compound eye pigmentation [IMP] intracellular signaling pathway [IEA] wing and notum subfield formation [IMP] oogenesis [IMP][TAS] cellular component movement [IMP] axon extension [IMP] establishment of planar polarity [TAS] establishment of imaginal disc-derived wing hair orientation [IMP] lamellipodium assembly [IMP]
Molecular Function:	protein binding [IEA] Notch binding [NAS] phosphatidic acid binding [IDA] signal transducer activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDADRGGGQE TKVIYHIDDE TTPYLVKIPI PSAQVTLRDF KLVLNKQNNN YKYFFKSMDA  60
   61 DFGVVKEEIA DDSTILPCFN GRVVSWLVSA DGTNQSDNCS ELPTSECELG MGLTNRKLQQ 120
  121 QQQQHQQQQQ QQQQQHQQQQ QQQQQQVQPV QLAQQQQQQV LHHQKMMGNP LLQPPPLTYQ 180
  181 SASVLSSDLD STSLFGTESE LTLDRDMTDY SSVQRLQVRK KPQRRKKRAP SMSRTSSYSS 240
  241 ITDSTMSLNI ITVSINMEAV NFLGISIVGQ SNRGGDGGIY VGSIMKGGAV ALDGRIEPGD 300
  301 MILQVNDVNF ENMTNDEAVR VLREVVQKPG PIKLVVAKCW DPNPKGYFTI PRTEPVRPID 360
  361 PGAWVAHTQA LTSHDSIIAD IAEPIKERLD QNNLEEIVKA MTKPDSGLEI RDRMWLKITI 420
  421 PNAFIGADAV NWVLENVEDV QDRREARRIV SAMLRSNYIK HTVNKLTFSE QCYYVVNEER 480
  481 NPNLLGRGHL HPHQLPHGHG GHALSHADTE SITSDIGPLP NPPIYMPYSA TYNPSHGYQP 540
  541 IQYGIAERHI SSGSSSSDVL TSKDISASQS DITSVIHQAN QLTIAAHGSN KSSGSSNRGG 600
  601 GGGGGGGGNN TNDQDVSVFN YVL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..94]	PSI-BLAST	8.69897	Crystal structure of axin dix domain
2	View Details	[95..241]	deduced	N/A	No confident structure predictions are available.
3	View Details	[242..350]	PSI-BLAST	20.154902	Solution Structure of mDvl1 PDZ domain
4	View Details	[351..484]	PSI-BLAST	19.69897	Segment polarity protein Dishevelled-1
5	View Details	[485..623]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: dsh-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: