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View Structure Prediction Details

Protein: dsh-PA
Organism: Drosophila melanogaster
Length: 623 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dsh-PA.

Description E-value Query
Range		 Subject
Range
gi|516485 - gi|516485|gb|AAA20216.1| dsh
 394.0 [0..1] [623..1]

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Predicted Domain #1
Region A:
Residues: [1-94] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDADRGGGQE TKVIYHIDDE TTPYLVKIPI PSAQVTLRDF KLVLNKQNNN YKYFFKSMDA  60
   61 DFGVVKEEIA DDSTILPCFN GRVVSWLVSA DGTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1wspA
Description: Crystal structure of axin dix domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [95-241] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSDNCSELPT SECELGMGLT NRKLQQQQQQ HQQQQQQQQQ QHQQQQQQQQ QQVQPVQLAQ  60
   61 QQQQQVLHHQ KMMGNPLLQP PPLTYQSASV LSSDLDSTSL FGTESELTLD RDMTDYSSVQ 120
  121 RLQVRKKPQR RKKRAPSMSR TSSYSSI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [242-350] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDSTMSLNII TVSINMEAVN FLGISIVGQS NRGGDGGIYV GSIMKGGAVA LDGRIEPGDM  60
   61 ILQVNDVNFE NMTNDEAVRV LREVVQKPGP IKLVVAKCWD PNPKGYFTI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.154902
Match: 1mc7A
Description: Solution Structure of mDvl1 PDZ domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
beta-catenin binding 2.62253122839661 bayes_pls_golite062009
binding 2.6196222853442 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
cytoskeletal protein binding 1.21190589781988 bayes_pls_golite062009
receptor binding 1.1444012779321 bayes_pls_golite062009
signal transducer activity 1.06018756723145 bayes_pls_golite062009
molecular transducer activity 1.06018756723145 bayes_pls_golite062009
transporter activity 0.782216866213126 bayes_pls_golite062009
transmembrane transporter activity 0.699604120098573 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
PDZ domain binding 0.53069705861477 bayes_pls_golite062009
substrate-specific transporter activity 0.434921764966531 bayes_pls_golite062009
actin binding 0.387046258192386 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.250590541549843 bayes_pls_golite062009
ErbB-2 class receptor binding 0.17411567599081 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [351-484] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRTEPVRPID PGAWVAHTQA LTSHDSIIAD IAEPIKERLD QNNLEEIVKA MTKPDSGLEI  60
   61 RDRMWLKITI PNAFIGADAV NWVLENVEDV QDRREARRIV SAMLRSNYIK HTVNKLTFSE 120
  121 QCYYVVNEER NPNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1fshA
Description: Segment polarity protein Dishevelled-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.88885372623841 bayes_pls_golite062009
transcription regulator activity 2.7317847461735 bayes_pls_golite062009
DNA binding 2.48559849769138 bayes_pls_golite062009
nucleic acid binding 2.38705965090247 bayes_pls_golite062009
transcription factor activity 1.86553483886232 bayes_pls_golite062009
transcription repressor activity 1.52072194290152 bayes_pls_golite062009
signal transducer activity 0.968719315363638 bayes_pls_golite062009
molecular transducer activity 0.968719315363638 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
sequence-specific DNA binding 0.57001406505152 bayes_pls_golite062009
transcription activator activity 0.376344018138683 bayes_pls_golite062009
receptor binding 0.0995086620605325 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [485-623] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGRGHLHPHQ LPHGHGGHAL SHADTESITS DIGPLPNPPI YMPYSATYNP SHGYQPIQYG  60
   61 IAERHISSGS SSSDVLTSKD ISASQSDITS VIHQANQLTI AAHGSNKSSG SSNRGGGGGG 120
  121 GGGGNNTNDQ DVSVFNYVL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle