Protein Overview: FBpp0312045, Ork...

General Information:
Name(s) found:	FBpp0312045 [FlyBase] Ork1-PA / FBpp0073261 [FlyBase] Ork1-PB / FBpp0073260 [FlyBase]
Description(s) found: Found 44 descriptions. SHOW ALL	type=protein; loc=X:complement(10772549..10774609,10775508..10775655,10775773..10775876,10775948..10776199,10776266..10776564,10780027..10780168); ID=FBpp0312045; name=Ork1-PD; parent=FBgn0017561,FBtr0346304; dbxref=FlyBase:FBpp0312045,FlyBase_Annotation_IDs:CG1615-PD; MD5=a1c6a328b2228b8f4d5e8e7d0bb71479; length=1001; release=r5.56; species=Dmel; [FlyBase] The gene Open rectifier K<sup>+</sup> channel 1 is referred to in FlyBase by the symbol Dmel\Ork1 (CG1615, FBgn0017561). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10772087..10784957. It has the cytological map location 9F7-9F8. It is reported to have molecular function</span>: outward rectifier potassium channel activity; potassium channel activity; inward rectifier potassium channel activity. There is experimental evidence that it is involved in the biological process</span>: locomotor rhythm; regulation of heart rate. 11 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval heart. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene Open rectifier K<sup>+</sup> channel 1 is referred to in FlyBase by the symbol Dmel\Ork1 (CG1615, FBgn0017561). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10772087..10784957. It has the cytological map location 9F7-9F8. It is reported to have molecular function</span>: outward rectifier potassium channel activity; potassium channel activity; inward rectifier potassium channel activity. There is experimental evidence that it is involved in the biological process</span>: locomotor rhythm; regulation of heart rate. 11 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval heart. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1001 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [ISS][NAS]
Biological Process:	potassium ion transport [IEA][NAS] regulation of heart rate [IMP] locomotor rhythm [IMP]
Molecular Function:	inward rectifier potassium channel activity [NAS] outward rectifier potassium channel activity [NAS] potassium channel activity [IEA][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPNRWILLL IFYISYLMFG AAIYYHIEHG EEKISRAEQR KAQIAINEYL LEELGDKNTT  60
   61 TQDEILQRIS DYCDKPVTLP PTYDDTPYTW TFYHAFFFAF TVCSTVGYGN ISPTTFAGRM 120
  121 IMIAYSVIGI PVNGILFAGL GEYFGRTFEA IYRRYKKYKM STDMHYVPPQ LGLITTVVIA 180
  181 LIPGIALFLL LPSWVFTYFE NWPYSISLYY SYVTTTTIGF GDYVPTFGAN QPKEFGGWFV 240
  241 VYQIFVIVWF IFSLGYLVMI MTFITRGLQS KKLAYLEQQL SSNLKATQNR IWSGVTKDVG 300
  301 YLRRMLNELY ILKVKPVYTD VDIAYTLPRS NSCPDLSMYR VEPAPIPSRK RAFSVCADMV 360
  361 AAQREAGMVH ANSDTELSKL DREKTFETAE AYRQTTDLLA KVVNALATVK PPPAEQEDAA 420
  421 LYGGYHGFSD SQILASEWSF STVNEFTSPR RPRARACSDF NLEAPRWQSE RPLRSSHNEW 480
  481 TWSGDNQQIQ EAFNQRYKGQ QRANGAANST MVHLEPDALE EQLKKQSPGA GRVKKFSMPD 540
  541 GLRRLFPFQK KRPSQDLERK LSVVSVPEGV ISQQARSPLD YYSNTVTAAS SQSYLRNGRG 600
  601 PPPPFESNGS LASGGGGLTN MGFQMEDGAT PPSALGGGAY QRKAAAGKRR RESIYTQNQA 660
  661 PSARRGSMYP PTAHALAQMQ MRRGSLATSG SGSAAMAAVA ARRGSLFPAT ASASSLTSAP 720
  721 RRSSIFSVTS EKDMNVLEQT TIADLIRALE VVHTHAVLDE QQQAAAAGGA AGGGGISRGS 780
  781 RKQRKMGNAG LEPPQLPPIL SLFAGDQTRT LQAAAANRLY ARRSTIVGIS PTGGAATAPA 840
  841 ARSLLEPPPS YTERAANQSQ ITAGPSNAPT VQSKFRRRFS VRPTALQIPP GQAPPPGASL 900
  901 MEQSSQTALQ RRLSLRPSPL ARELSPTSPP GGSGSALPAG AIDESGGTSA QRLLPLPAGT 960
  961 RPSTSSTHSP LSRIVQISQA QRKSSMPSAA ATGSSGAPAE K

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
inward rectifier potassium channel activity	5.0997110076666	bayes_pls_golite062009
potassium channel activity	3.07560078542081	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.98602674522518	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.96809690970616	bayes_pls_golite062009
voltage-gated potassium channel activity	2.89215814786806	bayes_pls_golite062009
cation transmembrane transporter activity	2.73807350248822	bayes_pls_golite062009
ligand-gated channel activity	2.72051922059922	bayes_pls_golite062009
ligand-gated ion channel activity	2.72051922059922	bayes_pls_golite062009
ion transmembrane transporter activity	2.67515190518646	bayes_pls_golite062009
voltage-gated cation channel activity	2.42997534485101	bayes_pls_golite062009
voltage-gated ion channel activity	2.36555310840994	bayes_pls_golite062009
voltage-gated channel activity	2.35294722733296	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.33083670641501	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.13014428099026	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.91774061209278	bayes_pls_golite062009
potassium ion transmembrane transporter activity	1.57069429249737	bayes_pls_golite062009
cation channel activity	1.43917477594689	bayes_pls_golite062009
channel activity	1.01956231306507	bayes_pls_golite062009
passive transmembrane transporter activity	1.01956231306507	bayes_pls_golite062009
substrate-specific channel activity	0.994513387627819	bayes_pls_golite062009
ion channel activity	0.990830355816173	bayes_pls_golite062009
gated channel activity	0.800384460449848	bayes_pls_golite062009
transporter activity	0.793769336118517	bayes_pls_golite062009
transmembrane transporter activity	0.635891484075352	bayes_pls_golite062009
substrate-specific transporter activity	0.555188550031886	bayes_pls_golite062009
signal transducer activity	0.293137523663314	bayes_pls_golite062009
molecular transducer activity	0.293137523663314	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009
binding	0.144628283348863	bayes_pls_golite062009
G-protein coupled receptor activity	0.135469305070471	bayes_pls_golite062009
receptor activity	0.113048653187164	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..173]	PSI-BLAST	24.0	Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
2	View Details	[174..431]	PSI-BLAST	17.39794	Potassium channel-related protein MthK
3	View Details	[432..601]	deduced	N/A	No confident structure predictions are available.
4	View Details	[602..788]	MSA	1.271995	View MSA. No confident structure predictions are available.
5	View Details	[789..1001]	MSA	5.272996	View MSA. No confident structure predictions are available.

Protein Overview: FBpp0312045, Ork...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: