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Protein Overview: otu-PC, otu-PB

General Information:
Name(s) found: otu-PC / FBpp0089325 [FlyBase]
otu-PB / FBpp0071181 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • The gene ovarian tumor is referred to in FlyBase by the symbol Dmel\otu (CG12743, FBgn0003023). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8379026..8383553. It has the cytological map location 7F1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: nucleic acid binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of DNA endoreduplication. 61 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; anatomical structure; female germline cyst; egg; organism; germline cell; germarium; nuclear part; cytoplasmic part; chorion; nuclear chromosome; fusome. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene ovarian tumor is referred to in FlyBase by the symbol Dmel\otu (CG12743, FBgn0003023). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8379026..8383553. It has the cytological map location 7F1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: nucleic acid binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of DNA endoreduplication. 61 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; anatomical structure; female germline cyst; egg; organism; germline cell; germarium; nuclear part; cytoplasmic part; chorion; nuclear chromosome; fusome. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 853 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    Biological Process: germ cell development [NAS][TAS]
    oogenesis [TAS]
    chromosome organization [TAS]
    female germ-line sex determination [NAS]
    germ-line cyst formation [TAS]
    germ-line sex determination [TAS]
    positive regulation of DNA endoreduplication [IMP]
    Molecular Function: nucleic acid binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMQVQRPIT SGSRQAPDPY DQYLESRGLY RKHTARDASS LFRVIAEQMY DTQMLHYEIR  60
   61 LECVRFMTLK RRIFEKEIPG DFDSYMQDMS KPKTYGTMTE LRAMSCLYRR NVILYEPYNM 120
  121 GTSVVFNRRY AENFRVFFNN ENHFDSVYDV EYIERAAICQ SIAFKLLYQK LFKLPDVSFA 180
  181 VEIMLHPHTF NWDRFNVEFD DKGYMVRIHC TDGRVFKLDL PGDTNCILEN YKLCNFHSTN 240
  241 GNQSINARKG GRLEIKNQEE RKASGSSGHE PNDLLPMCPN RLESCVRQLL DDGISPFPYK 300
  301 VAKSMDPYMY RNIEFDCWND MRKEAKLYNV YINDYNFKVG AKCKVELPNE TEMYTCHVQN 360
  361 ISKDKNYCHV FVERIGKEIV VPYESLHPLP PDEYRPWSLP FRYHRQMPRL PLPKYAGKAN 420
  421 KSSKWKKNKL FEMDQYFEHS KCDLMPYMPV DNCYQGVHIQ DDEQRDHNDP EQNDQNPTTE 480
  481 QRDREEPQAQ KQHQRTKASR VQPQNSSSSQ NQEVSGSAAP PPTQYMNYVP MIPSRPGHLP 540
  541 PPWPASPMAI AEEFPFPISG TPHPPPTEGC VYMPFGGYGP PPPGAVALSG PHPFMPLPSP 600
  601 PLNVTGIGEP RRSLHPNGED LPVDMVTLRY FYNMGVDLHW RMSHHTPPDE LGMFGYHQQN 660
  661 NTDQQAGRTV VIGATEDNLT AVESTPPPSP EVANATEQSP LEKSAYAKRN LNSVKVRGKR 720
  721 PEQLQDIKDS LGPAAFLPTP TPSPSSNGSQ FSFYTTPSPH HHLITPPRLL QPPPPPPIFY 780
  781 HKAGPPQLGG AAQGQTPYAW GMPAPVVSPY EVINNYNMDP SAQPQQQQPA TLQPAPLSVQ 840
  841 SQPAAVYAAT RHH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] FFAS03 2.3 Structure of Otubain-2
    2 View Details [231..387] deduced N/A No confident structure predictions are available.
    3 View Details [388..601] MSA 2.233996 View MSA. No confident structure predictions are available.
    4 View Details [602..719] MSA 1.238994 View MSA. No confident structure predictions are available.
    5 View Details [720..853] MSA 4.224996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.88517380556644 bayes_pls_golite062009
  • binding
    		•  1.28926196684576 bayes_pls_golite062009
  • catalytic activity
    		•  0.995453662223124 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.896894355256917 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.864586149211676 bayes_pls_golite062009
  • DNA binding
    		•  0.816807038934629 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.549530710974169 bayes_pls_golite062009
  • peptidase activity
    		•  0.302979577950347 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.292810452153222 bayes_pls_golite062009
  • transcription activator activity
    		•  0.188306014444124 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0522574655989047 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle