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Protein Overview: ct-PA

General Information:
Name(s) found: ct-PA / FBpp0071026 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene cut is referred to in FlyBase by the symbol Dmel\ct (CG11387, FBgn0004198). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7503181..7570056. It has the cytological map location 7B4-7B6. It is reported to have molecular function</span>: specific RNA polymerase II transcription factor activity; DNA binding. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; organ development; antennal development; regulation of biological process; multicellular organism reproduction; appendage development; gamete generation; cell cycle; regulation of metabolic process; sensory perception of mechanical stimulus; negative regulation of Notch signaling pathway. 320 alleles are reported. The phenotypes of these alleles are annotated with 50 unique terms, many of which group under: adult segment; peripheral nervous system; nervous system; adult mesothoracic segment; organ system; spiracle; female germline cyst; multidendritic neuron; integumentary specialisation; external compound sense organ; antennal segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2175 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: sensory organ boundary specification [NAS]
    spiracle morphogenesis, open tracheal system [IMP]
    regulation of gene-specific transcription [IMP]
    Malpighian tubule morphogenesis [NAS][TAS]
    imaginal disc-derived wing margin morphogenesis [IMP][NAS]
    peripheral nervous system development [TAS]
    regulation of transcription, DNA-dependent [IEA]
    female gonad development [TAS]
    antennal development [IEP][IMP]
    regulation of transcription [IEA]
    negative regulation of Notch signaling pathway [IMP]
    mitotic cell cycle [IMP]
    open tracheal system development [TAS]
    dendrite morphogenesis [IMP][TAS]
    sensory perception of sound [IMP]
    antennal joint development [IMP]
    ovarian follicle cell stalk formation [TAS]
    central nervous system development [TAS]
    oogenesis [IMP]
    sensory organ precursor cell fate determination [NAS]
    ovarian follicle cell development [IMP]
    cell fate commitment [NAS]
    Molecular Function: DNA binding [NAS][TAS]
    transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPTLPQAAG TADMDLTAVQ SINDWFFKKE QIYLLAQFWQ QRATLAEKEV NTLKEQLSTG  60
   61 NPDSNLNSEN SDTAAAAATA AAVAAVVAGA TATNDIEDEQ QQQLQQTASG GILESDSDKL 120
  121 LNSSIVAAAI TLQQQNGSNL LANTNTPSPS PPLLSAEQQQ QLQSSLQQSG GVGGACLNPK 180
  181 LFFNHAQQMM MMEAAAAAAA AALQQQQQQQ SPLHSPANEV AIPTEQPAAT VATGAAAAAA 240
  241 AAATPIATGN VKSGSTTSNA NHTNSNNSHQ DEEELDDEEE DEEEDEDEDD EEENASMQSN 300
  301 ADDMELDAQQ ETRTEPSATT QQQHQQQDTE DLEENKDAGE ASLNVSNNHN TTDSNNSCSR 360
  361 KNNNGGNESE QHVASSAEDD DCANNNTNTS NNNNTSNTAT SNTNNNNNNN SSSGNSEKRK 420
  421 KKNNNNNNGQ PAVLLAAKDK EIKALLDELQ RLRAQEQTHL VQIQRLEEHL EVKRQHIIRL 480
  481 EARLDKQQIN EALAEATALS AAASTNNNNN SQSSDNNKKL NTAAERPMDA SSNADLPEST 540
  541 KAPVPAEDDE EDEDQAMLVD SEEAEDKPED SHHDDDEDED EDREAVNATT TDSNELKIKK 600
  601 EQHSPLDLNV LSPNSAIAAA AAAAAAAACA NDPNKFQALL IERTKALAAE ALKNGASDAL 660
  661 SEDAHHQQQQ HHQQQHQHQQ QHHQQQHLHQ QHHHHLQQQP NSGSNSNPAS NDHHHGHHLH 720
  721 GHGLLHPSSA HHLHHQTTES NSNSSTPTAA GNNNGSNNSS SNTNANSTAQ LAASLASTLN 780
  781 GTKSLMQEDS NGLAAVAMAA HAQHAAALGP GFLPGLPAFQ FAAAQVAAGG DGRGHYRFAD 840
  841 SELQLPPGAS MAGRLGESLI PKGDPMEAKL QEMLRYNMDK YANQALDTLH ISRRVRELLS 900
  901 VHNIGQRLFA KYILGLSQGT VSELLSKPKP WDKLTEKGRD SYRKMHAWAC DDNAVMLLKS 960
  961 LIPKKDSGLP QYAGRGAGGA GGDDSMSEDR IAHILSEASS LMKQSSVAQH REQERRSHGG1020
 1021 EDSHSNEDSK SPPQSCTSPF FKVENQLKQH QHLNPEQAAA QQREREREQR EREQQQRLRH1080
 1081 DDQDKMARLY QELIARTPRE TAFPSFLFSP SLFGGAAGMP GAASNAFPAM ADENMRHVFE1140
 1141 REIAKLQQHQ QQQQAAQAQA QFPNFSSLMA LQQQVLNGAQ DLSLAAAAAK DIKLNGQRSS1200
 1201 LEHSAGSSSC SKDGERDDAY PSSLHGRKSE GGGTPAPPAP PSGPGTGAGA PPTAAPPTGG1260
 1261 ASSNSAAPSP LSNSILPPAL SSQGEEFAAT ASPLQRMASI TNSLITQPPV TPHHSTPQRP1320
 1321 TKAVLPPITQ QQFDMFNNLN TEDIVRRVKE ALSQYSISQR LFGESVLGLS QGSVSDLLAR1380
 1381 PKPWHMLTQK GREPFIRMKM FLEDENAVHK LVASQYKIAP EKLMRTGSYS GSPQMPQGLA1440
 1441 SKMQAASLPM QKMMSELKLQ EPAQAQHLMQ QMQAAAMSAA MQQQQVAQAQ QQAQQAQQAQ1500
 1501 QHLQQQAQQH LQQQQHLAQQ QHPHQQHHQA AAAAAALHHQ SMLLTSPGLP PQHAISLPPS1560
 1561 AGGAQPGGPG GNQGSSNPSN SEKKPMLMPV HGTNAMRSLH QHMSPTVYEM AALTQDLDTH1620
 1621 DITTKIKEAL LANNIGQKIF GEAVLGLSQG SVSELLSKPK PWHMLSIKGR EPFIRMQLWL1680
 1681 SDANNVERLQ LLKNERREAS KRRRSTGPNQ QDNSSDTSSN DTNDFYTSSP GPGSVGSGVG1740
 1741 GAPPSKKQRV LFSEEQKEAL RLAFALDPYP NVGTIEFLAN ELGLATRTIT NWFHNHRMRL1800
 1801 KQQVPHGPAG QDNPIPSRES TSATPFDPVQ FRILLQQRLL ELHKERMGMS GAPIPYPPYF1860
 1861 AAAAILGRSL AGIPGAAAAA GAAAAAAAVG ASGGDELQAL NQAFKEQMSG LDLSMPTLKR1920
 1921 ERSDDYQDDL ELEGGGHNLS DNESLEGQEP EDKTTDYEKV LHKSALAAAA AYMSNAVRSS1980
 1981 RRKPAAPQWV NPAGAVTNPS AVVAAVAAAA AAAADNERII NGVCVMQASE YGRDDTDSNK2040
 2041 PTDGGNDSDH EHAQLEIDQR FMEPEVHIKQ EEDDDEEQSG SVNLDNEDNA TSEQKLKVIN2100
 2101 EEKLRMVRVR RLSSTGGGSS EEMPAPLAPP PPPPAASSSI VSGESTTSSS SSSNTSSSTP2160
 2161 AVTTAAATAA AGWNY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] MSA 1.400995 View MSA. No confident structure predictions are available.
    2 View Details [214..311] deduced N/A No confident structure predictions are available.
    3 View Details [312..603] PSI-BLAST 3.30103 bI3 LAGLIDADG Maturase
    4 View Details [604..848] deduced N/A No confident structure predictions are available.
    5 View Details [849..1079] FFAS03 3.84 Solution structure of the MAR-binding domain of SATB1
    6 View Details [1080..1303] deduced N/A No confident structure predictions are available.
    7 View Details [1304..1465] PSI-BLAST 16.0 Solution structure of the CUT domain of human homeobox protein Cux-2 (Cut-like 2)
    8 View Details [1466..1609] deduced N/A No confident structure predictions are available.
    9 View Details [1610..1703] PSI-BLAST 18.39794 Solution structure of the third CUT domain of human Homeobox protein Cux-2
    10 View Details [1704..1829] PSI-BLAST 16.39794 Paired protein
    11 View Details [1830..2031] deduced N/A No confident structure predictions are available.
    12 View Details [2032..2175] MSA 1.046995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • DNA binding
    		•  3.86911713514757 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.63564136141664 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.27108390804937 bayes_pls_golite062009
  • transcription factor activity
    		•  2.39772912634222 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.92710012736048 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.14923363018972 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.11933441662734 bayes_pls_golite062009
  • transcription factor binding
    		•  0.81012694010964 bayes_pls_golite062009
  • transcription activator activity
    		•  0.73783399202954 bayes_pls_golite062009
  • protein binding
    		•  0.506038775283948 bayes_pls_golite062009
  • chromatin binding
    		•  0.39159401845196 bayes_pls_golite062009
    8 No functions predicted.
    9
    Term Confidence Notes
  • DNA binding
    		•  3.86911713514757 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.63564136141664 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.27108390804937 bayes_pls_golite062009
  • transcription factor activity
    		•  2.39772912634222 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.92710012736048 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.14923363018972 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.11933441662734 bayes_pls_golite062009
  • transcription factor binding
    		•  0.81012694010964 bayes_pls_golite062009
  • transcription activator activity
    		•  0.73783399202954 bayes_pls_golite062009
  • protein binding
    		•  0.506038775283948 bayes_pls_golite062009
  • chromatin binding
    		•  0.39159401845196 bayes_pls_golite062009
    10
    Term Confidence Notes
  • transcription regulator activity
    		•  3.3573497204506 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • DNA binding
    		•  3.0205295442286 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.77547609431902 bayes_pls_golite062009
  • transcription factor activity
    		•  2.57014522504183 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.08714353704046 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.41102023549536 bayes_pls_golite062009
  • transcription factor binding
    		•  1.1887755957055 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.06075239560835 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • chromatin binding
    		•  0.807185147096719 bayes_pls_golite062009
  • transcription activator activity
    		•  0.68518521953823 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.57338514991304 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.336563012956291 bayes_pls_golite062009
    11 No functions predicted.
    12 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle