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View Structure Prediction Details

Protein: ct-PA
Organism: Drosophila melanogaster
Length: 2175 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ct-PA.

Description E-value Query
Range		 Subject
Range
gi|57906798, gi|... - gi|57906798|ref|XP_551658.1| ENSANGP00000025820 [Anopheles gambiae str. PEST], gi|55234154|gb|EAL386...
 418.0 [0..1028] [2027..62]

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Predicted Domain #1
Region A:
Residues: [1-213] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPTLPQAAG TADMDLTAVQ SINDWFFKKE QIYLLAQFWQ QRATLAEKEV NTLKEQLSTG  60
   61 NPDSNLNSEN SDTAAAAATA AAVAAVVAGA TATNDIEDEQ QQQLQQTASG GILESDSDKL 120
  121 LNSSIVAAAI TLQQQNGSNL LANTNTPSPS PPLLSAEQQQ QLQSSLQQSG GVGGACLNPK 180
  181 LFFNHAQQMM MMEAAAAAAA AALQQQQQQQ SPL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [214-311] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSPANEVAIP TEQPAATVAT GAAAAAAAAA TPIATGNVKS GSTTSNANHT NSNNSHQDEE  60
   61 ELDDEEEDEE EDEDEDDEEE NASMQSNADD MELDAQQE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [312-603] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRTEPSATTQ QQHQQQDTED LEENKDAGEA SLNVSNNHNT TDSNNSCSRK NNNGGNESEQ  60
   61 HVASSAEDDD CANNNTNTSN NNNTSNTATS NTNNNNNNNS SSGNSEKRKK KNNNNNNGQP 120
  121 AVLLAAKDKE IKALLDELQR LRAQEQTHLV QIQRLEEHLE VKRQHIIRLE ARLDKQQINE 180
  181 ALAEATALSA AASTNNNNNS QSSDNNKKLN TAAERPMDAS SNADLPESTK APVPAEDDEE 240
  241 DEDQAMLVDS EEAEDKPEDS HHDDDEDEDE DREAVNATTT DSNELKIKKE QH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 2ab5A
Description: bI3 LAGLIDADG Maturase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [604-848] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLDLNVLSP NSAIAAAAAA AAAAACANDP NKFQALLIER TKALAAEALK NGASDALSED  60
   61 AHHQQQQHHQ QQHQHQQQHH QQQHLHQQHH HHLQQQPNSG SNSNPASNDH HHGHHLHGHG 120
  121 LLHPSSAHHL HHQTTESNSN SSTPTAAGNN NGSNNSSSNT NANSTAQLAA SLASTLNGTK 180
  181 SLMQEDSNGL AAVAMAAHAQ HAAALGPGFL PGLPAFQFAA AQVAAGGDGR GHYRFADSEL 240
  241 QLPPG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [849-1079] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASMAGRLGES LIPKGDPMEA KLQEMLRYNM DKYANQALDT LHISRRVREL LSVHNIGQRL  60
   61 FAKYILGLSQ GTVSELLSKP KPWDKLTEKG RDSYRKMHAW ACDDNAVMLL KSLIPKKDSG 120
  121 LPQYAGRGAG GAGGDDSMSE DRIAHILSEA SSLMKQSSVA QHREQERRSH GGEDSHSNED 180
  181 SKSPPQSCTS PFFKVENQLK QHQHLNPEQA AAQQRERERE QREREQQQRL R

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.84
Match: 1yseA
Description: Solution structure of the MAR-binding domain of SATB1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1080-1303] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDDQDKMARL YQELIARTPR ETAFPSFLFS PSLFGGAAGM PGAASNAFPA MADENMRHVF  60
   61 EREIAKLQQH QQQQQAAQAQ AQFPNFSSLM ALQQQVLNGA QDLSLAAAAA KDIKLNGQRS 120
  121 SLEHSAGSSS CSKDGERDDA YPSSLHGRKS EGGGTPAPPA PPSGPGTGAG APPTAAPPTG 180
  181 GASSNSAAPS PLSNSILPPA LSSQGEEFAA TASPLQRMAS ITNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1304-1465] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LITQPPVTPH HSTPQRPTKA VLPPITQQQF DMFNNLNTED IVRRVKEALS QYSISQRLFG  60
   61 ESVLGLSQGS VSDLLARPKP WHMLTQKGRE PFIRMKMFLE DENAVHKLVA SQYKIAPEKL 120
  121 MRTGSYSGSP QMPQGLASKM QAASLPMQKM MSELKLQEPA QA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1x2lA
Description: Solution structure of the CUT domain of human homeobox protein Cux-2 (Cut-like 2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 3.86911713514757 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
nucleic acid binding 3.63564136141664 bayes_pls_golite062009
transcription regulator activity 3.27108390804937 bayes_pls_golite062009
transcription factor activity 2.39772912634222 bayes_pls_golite062009
transcription repressor activity 1.92710012736048 bayes_pls_golite062009
sequence-specific DNA binding 1.14923363018972 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.11933441662734 bayes_pls_golite062009
transcription factor binding 0.81012694010964 bayes_pls_golite062009
transcription activator activity 0.73783399202954 bayes_pls_golite062009
protein binding 0.506038775283948 bayes_pls_golite062009
chromatin binding 0.39159401845196 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1466-1609] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHLMQQMQAA AMSAAMQQQQ VAQAQQQAQQ AQQAQQHLQQ QAQQHLQQQQ HLAQQQHPHQ  60
   61 QHHQAAAAAA ALHHQSMLLT SPGLPPQHAI SLPPSAGGAQ PGGPGGNQGS SNPSNSEKKP 120
  121 MLMPVHGTNA MRSLHQHMSP TVYE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1610-1703] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALTQDLDT HDITTKIKEA LLANNIGQKI FGEAVLGLSQ GSVSELLSKP KPWHMLSIKG  60
   61 REPFIRMQLW LSDANNVERL QLLKNERREA SKRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.39794
Match: 1wh8A
Description: Solution structure of the third CUT domain of human Homeobox protein Cux-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 3.86911713514757 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
nucleic acid binding 3.63564136141664 bayes_pls_golite062009
transcription regulator activity 3.27108390804937 bayes_pls_golite062009
transcription factor activity 2.39772912634222 bayes_pls_golite062009
transcription repressor activity 1.92710012736048 bayes_pls_golite062009
sequence-specific DNA binding 1.14923363018972 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.11933441662734 bayes_pls_golite062009
transcription factor binding 0.81012694010964 bayes_pls_golite062009
transcription activator activity 0.73783399202954 bayes_pls_golite062009
protein binding 0.506038775283948 bayes_pls_golite062009
chromatin binding 0.39159401845196 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1704-1829] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSTGPNQQDN SSDTSSNDTN DFYTSSPGPG SVGSGVGGAP PSKKQRVLFS EEQKEALRLA  60
   61 FALDPYPNVG TIEFLANELG LATRTITNWF HNHRMRLKQQ VPHGPAGQDN PIPSRESTSA 120
  121 TPFDPV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.39794
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.3573497204506 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
DNA binding 3.0205295442286 bayes_pls_golite062009
nucleic acid binding 2.77547609431902 bayes_pls_golite062009
transcription factor activity 2.57014522504183 bayes_pls_golite062009
transcription repressor activity 2.08714353704046 bayes_pls_golite062009
sequence-specific DNA binding 1.41102023549536 bayes_pls_golite062009
transcription factor binding 1.1887755957055 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.06075239560835 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
chromatin binding 0.807185147096719 bayes_pls_golite062009
transcription activator activity 0.68518521953823 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.57338514991304 bayes_pls_golite062009
transcription corepressor activity 0.336563012956291 bayes_pls_golite062009

Predicted Domain #11
Region A:
Residues: [1830-2031] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFRILLQQRL LELHKERMGM SGAPIPYPPY FAAAAILGRS LAGIPGAAAA AGAAAAAAAV  60
   61 GASGGDELQA LNQAFKEQMS GLDLSMPTLK RERSDDYQDD LELEGGGHNL SDNESLEGQE 120
  121 PEDKTTDYEK VLHKSALAAA AAYMSNAVRS SRRKPAAPQW VNPAGAVTNP SAVVAAVAAA 180
  181 AAAAADNERI INGVCVMQAS EY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [2032-2175] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRDDTDSNKP TDGGNDSDHE HAQLEIDQRF MEPEVHIKQE EDDDEEQSGS VNLDNEDNAT  60
   61 SEQKLKVINE EKLRMVRVRR LSSTGGGSSE EMPAPLAPPP PPPAASSSIV SGESTTSSSS 120
  121 SSNTSSSTPA VTTAAATAAA GWNY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle