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Protein Overview: Sirt4-PB, Sirt4-PA

General Information:
Name(s) found: Sirt4-PB / FBpp0070816 [FlyBase]
Sirt4-PA / FBpp0070815 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • The gene Sirt4 is referred to in FlyBase by the symbol Dmel\Sirt4 (CG3187, FBgn0029783). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:5558661..5560002. It has the cytological map location 5A10. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; zinc ion binding; NAD binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein amino acid deacetylation; chromatin silencing. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Sirt4 is referred to in FlyBase by the symbol Dmel\Sirt4 (CG3187, FBgn0029783). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:5558661..5560002. It has the cytological map location 5A10. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; zinc ion binding; NAD binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein amino acid deacetylation; chromatin silencing. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 229 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid deacetylation [IEA]
    chromatin silencing [IEA]
    regulation of transcription [IEA]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [IEA]
    zinc ion binding [IEA]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEFVKSSAVR KRYWARNFVG WPKFSATQPN ATHHALARFE REERVQAVVT QNVDRLHTKA  60
   61 GSRNVVEVHG SGYVVKCLSC EYRIDRHEFQ SILASLNPAF KDAPDMIRPD GDVEIPLEYI 120
  121 ENFRIPECTQ CGGDLKPEIV FFGDSVPRPR VDQIAGMVYN SDGLLVLGSS LLVFSGYRVV 180
  181 LQTKDLKLPV GIVNIGETRA DHLADIKISA KCGDVIPKLF DFRNSKSVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] PSI-BLAST 55.0 AF1676, Sir2 homolog (Sir2-AF1?)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  1.35219834199205 bayes_pls_golite062009
  • binding
    		•  1.24906798936318 bayes_pls_golite062009
  • catalytic activity
    		•  1.1096503360938 bayes_pls_golite062009
  • DNA binding
    		•  0.5242184522659 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  0.42310930197448 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  0.42310930197448 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.380787768454355 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.264248333756411 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.24829333073166 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle