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View Structure Prediction Details

Protein: Sirt4-PB, Sirt4-PA
Organism: Drosophila melanogaster
Length: 229 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sirt4-PB, Sirt4-PA.

Description E-value Query
Range
Subject
Range
SIR4_BOVIN - NAD-dependent protein lipoamidase sirtuin-4, mitochondrial OS=Bos taurus GN=SIRT4 PE=2 SV=1
236.0 [0..2] [222..95]

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Predicted Domain #1
Region A:
Residues: [1-229]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEFVKSSAVR KRYWARNFVG WPKFSATQPN ATHHALARFE REERVQAVVT QNVDRLHTKA  60
   61 GSRNVVEVHG SGYVVKCLSC EYRIDRHEFQ SILASLNPAF KDAPDMIRPD GDVEIPLEYI 120
  121 ENFRIPECTQ CGGDLKPEIV FFGDSVPRPR VDQIAGMVYN SDGLLVLGSS LLVFSGYRVV 180
  181 LQTKDLKLPV GIVNIGETRA DHLADIKISA KCGDVIPKLF DFRNSKSVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.0
Match: 1m2gA
Description: AF1676, Sir2 homolog (Sir2-AF1?)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.35219834199205 bayes_pls_golite062009
binding 1.24906798936318 bayes_pls_golite062009
catalytic activity 1.1096503360938 bayes_pls_golite062009
DNA binding 0.5242184522659 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 0.42310930197448 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 0.42310930197448 bayes_pls_golite062009
nucleic acid binding 0.380787768454355 bayes_pls_golite062009
histone deacetylase activity 0.264248333756411 bayes_pls_golite062009
protein deacetylase activity 0.24829333073166 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle