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Protein Overview: Cbp80-PA, Cbp80-PB

General Information:
Name(s) found: Cbp80-PB / FBpp0070652 [FlyBase]
Cbp80-PA / FBpp0070651 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene cap binding protein 80 is referred to in FlyBase by the symbol Dmel\Cbp80 (CG7035, FBgn0022942). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4544054..4552292. It has the cytological map location 4C11. Based on sequence similarity, it is predicted to have molecular function</span>: RNA cap binding. There is experimental evidence that it is involved in the biological process</span>: production of siRNA involved in RNA interference; negative regulation of viral genome replication; gene silencing by miRNA. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene cap binding protein 80 is referred to in FlyBase by the symbol Dmel\Cbp80 (CG7035, FBgn0022942). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4544054..4552292. It has the cytological map location 4C11. Based on sequence similarity, it is predicted to have molecular function</span>: RNA cap binding. There is experimental evidence that it is involved in the biological process</span>: production of siRNA involved in RNA interference; negative regulation of viral genome replication; gene silencing by miRNA. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 800 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    nuclear cap binding complex [ISS]
    catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    Biological Process: RNA metabolic process [IEA]
    gene silencing by miRNA [IMP]
    production of siRNA involved in RNA interference [IMP]
    negative regulation of viral genome replication [IMP]
    nuclear mRNA splicing, via spliceosome [IC][ISS]
    Molecular Function: protein binding [IEA]
    RNA cap binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRRRAHDTE DEGYDHRRNK RRRVSENQEI EDRLESLILR VGERSTSSVE SNLEGLVSVL  60
   61 EADLGTFRLK ILRILSDCAV RMPEKCTVYT TLVGLLNAKN YKFGGEFVDH MVKTFKESLK 120
  121 MCRWDAARYS LRFLADLVNC HVISATSLLQ LLDTMIDVSN EDTVPQVRRD WFVFAVLSTL 180
  181 PWVGRDLYEK KESALESLLL RIEVYLNKRS KKHHNALRVW SSDAPHPQEE YLDCLWAQIR 240
  241 KLRQDNWAEK HIPRPYLVFD SILCEALQHN LPTIVPPPHH DNFEYPMPWV VYRMFDYTDC 300
  301 PDGPNLPGAH SIERFLIEEH LHHIIETYHH ERKDCAAQLL SFPYKHKIPL EYCIVEVVFA 360
  361 ELFHMPTPRY LDICYGSILI ELCKLQPATL PQVLAQATEI LFMRIDSMNT SCFDRFVNWF 420
  421 SYHLSNFKFT WSWDEWDSCL LLDGEHPRPK FIQEVLQKCL RLSYHQRITE MMPTTYAKLI 480
  481 PLTPVPNYKY ANEEAANLPG TTVAHQLVVA IRQKCTPEEV VNILKDIPNS GYSGEEMSDG 540
  541 SFNALKIDVF VQTLLNLGSK SFSHSFAAIS KFHSVFRALA ETEEAQICIL HNIFELWSSH 600
  601 QQMMVVLIDK LLKLQIVDCS AVATWIFSKE MTGEFTKLYL WEILHLTIKK MNKHVIKLNT 660
  661 ELSEAKEKLA KADSSSSDSE DDSSHKRKKP ITHADKPSEE VVERMEEKLE AANVNQKRLF 720
  721 LIVFQRFIMI LSEHLLRSDT DGRDPDTDWY RWTIGRLQQV FLMHHEQVQK YSSTLETLLF 780
  781 TSDLDTHILE VFQQFVALRA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..800] PSI-BLAST 1000.0 CBP80, 80KDa nuclear cap-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA cap binding
    		•  6.31996430626206 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein binding
    		•  2.78733902345842 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.74745843355294 bayes_pls_golite062009
  • RNA binding
    		•  2.62683106046883 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90912542848632 bayes_pls_golite062009
  • DNA binding
    		•  1.77040152722002 bayes_pls_golite062009
  • transcription activator activity
    		•  1.33885628961586 bayes_pls_golite062009
  • transcription factor activity
    		•  1.27944481949335 bayes_pls_golite062009
  • mRNA binding
    		•  1.24616647164637 bayes_pls_golite062009
  • RNA 7-methylguanosine cap binding
    		•  0.841392474686331 bayes_pls_golite062009
  • transcription factor binding
    		•  0.00210118982863072 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle