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Protein Overview: dnc-PI, dnc-PJ

General Information:
Name(s) found: dnc-PJ / FBpp0070489 [FlyBase]
dnc-PI / FBpp0070487 [FlyBase]
Description(s) found:
Found 40 descriptions.
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  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1070 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nonassociative learning [TAS]
    signal transduction [IEA]
    cyclic nucleotide metabolic process [NAS]
    synaptic transmission [IMP]
    olfactory learning [TAS]
    behavioral response to ethanol [NAS]
    learning [NAS]
    circadian rhythm [TAS]
    associative learning [TAS]
    memory [TAS]
    behavior [TAS]
    reproduction [NAS]
    conditioned taste aversion [IMP]
    learning or memory [NAS][TAS]
    mating behavior [TAS]
    short-term memory [IMP]
    oogenesis [TAS]
    locomotor rhythm [NAS]
    axon extension [IMP]
    courtship behavior [TAS]
    cAMP-mediated signaling [NAS]
    Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity [ISS][TAS]
    3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQESNGGPA AGGGAAAAPP PPPQYIITTP SEVDPDEVRS MADLELGSPE KQVQVQSQKF  60
   61 SSTSSTTKVA THSFSMSSSA GTTGQQSKQD SAQQIQQLQQ LQQLQQLQQQ QQQQQSQRII 120
  121 SSSTRSQSLQ SSTIVGEATT ITSGAAQILS ASAAASLAQQ LKAQSSTSII TSSEQRTSTS 180
  181 TSSSSSTRYI ASGSSNLAGG NSNSASSASS KTRFQSFLQQ PEGAHGFLTA HQKHVRQFVR 240
  241 STSAHSEAAA GVAGARAEKC IRSASTQIDD ASVAGVVESA GNLTDSSATG GSMQLSMSKL 300
  301 GLQQSSSILI SKSAETIEMK SSSAGMRTQL TLSGGFLAPP GNRKITILSP IHAPPGLHDM 360
  361 LKRAQGRSPL SPRISFPGSD SDLFGFDVEN GQGARSPLEG GSPSAGLVLQ NLPQRRESFL 420
  421 YRSDSDFEMS PKSMSRNSSI ASERFKEQEA SILVDRSHGE DLIVTPFAQI LASLRSVRNN 480
  481 LLSLTNVPAS NKSRRPNQSS SASRSGNPPG APLSQGEEAY TRLATDTIEE LDWCLDQLET 540
  541 IQTHRSVSDM ASLKFKRMLN KELSHFSESS RSGNQISEYI CSTFLDKQQE FDLPSLRVED 600
  601 NPELVAANAA AGQQSAGQYA RSRSPRGPPM SQISGVKRPL SHTNSFTGER LPTFGVETPR 660
  661 ENELGTLLGE LDTWGIQIFS IGEFSVNRPL TCVAYTIFQS RELLTSLMIP PKTFLNFMST 720
  721 LEDHYVKDNP FHNSLHAADV TQSTNVLLNT PALEGVFTPL EVGGALFAAC IHDVDHPGLT 780
  781 NQFLVNSSSE LALMYNDESV LENHHLAVAF KLLQNQGCDI FCNMQKKQRQ TLRKMVIDIV 840
  841 LSTDMSKHMS LLADLKTMVE TKKVAGSGVL LLDNYTDRIQ VLENLVHCAD LSNPTKPLPL 900
  901 YKRWVALLME EFFLQGDKER ESGMDISPMC DRHNATIEKS QVGFIDYIVH PLWETWADLV 960
  961 HPDAQDILDT LEENRDYYQS MIPPSPPPSG VDENPQEDRI RFQVTLEESD QENLAELEEG1020
 1021 DESGGESTTT GTTGTTAASA LSGAGGGGGG GGGMAPRTGG CQNQPQHGGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..45] MSA 1.005992 View MSA. No confident structure predictions are available.
    2 View Details [46..174] deduced N/A No confident structure predictions are available.
    3 View Details [175..322] MSA 1.027962 View MSA. No confident structure predictions are available.
    4 View Details [323..498] MSA 4.122973 View MSA. No confident structure predictions are available.
    5 View Details [499..588] MSA 1.220989 View MSA. No confident structure predictions are available.
    6 View Details [589..1070] PSI-BLAST 143.0 No description for 2fm0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  4.70762025272187 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  4.66767157264894 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  4.40961779134517 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  3.68838886134169 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.64567538445993 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.26293733853576 bayes_pls_golite062009
  • hydrolase activity
    		•  1.17086565360856 bayes_pls_golite062009
  • catalytic activity
    		•  1.07048165010262 bayes_pls_golite062009
  • binding
    		•  0.994379083280533 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.893957699588543 bayes_pls_golite062009
  • protein binding
    		•  0.162314119157812 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle