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Protein Overview: dnc-PB, FBpp0305507

General Information:
Name(s) found: FBpp0305507 [FlyBase]
dnc-PB / FBpp0070485 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:join(3138831..3138887,3139106..3140228,3140328..3140718,3215074..3215250,3219960..3219998,3226475..3226579,3228178..3228364,3228588..3228681,3231275..3231615,3231722..3231986,3232059..3232173,3232248..3232410,3232481..3232849,3233003..3233206); ID=FBpp0305507; name=dnc-PS; parent=FBgn0000479,FBtr0333315; dbxref=REFSEQ:NP_726846,GB_protein:AAN09599,FlyBase:FBpp0305507,FlyBase_Annotation_IDs:CG32498-PS; MD5=caab4637c9f1151c017b40e3df1524cb; length=1209; release=r5.56; species=Dmel; [FlyBase]
  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1209 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nonassociative learning [TAS]
    signal transduction [IEA]
    cyclic nucleotide metabolic process [NAS]
    synaptic transmission [IMP]
    olfactory learning [TAS]
    behavioral response to ethanol [NAS]
    learning [NAS]
    circadian rhythm [TAS]
    associative learning [TAS]
    memory [TAS]
    behavior [TAS]
    reproduction [NAS]
    conditioned taste aversion [IMP]
    learning or memory [NAS][TAS]
    mating behavior [TAS]
    short-term memory [IMP]
    oogenesis [TAS]
    locomotor rhythm [NAS]
    axon extension [IMP]
    courtship behavior [TAS]
    cAMP-mediated signaling [NAS]
    Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity [ISS][TAS]
    3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRLARFTQG FSFNKNVAKH RGSGSSNGTG NGSGTGNGQG LGGSCSANGL AATGGVGGGG  60
   61 GSGSGGGGCG SGSGSGSGKR KSKARTKCFG GTVFRCCLPC RGGGSAAPAT SPPQTPAQTP 120
  121 DELKVIPEDC NLEKSAEQKR DLLERNNKED DLLNRTVSGS ELDLYGGAGG GTKKHSLADT 180
  181 IDTSVTTPIS LKTLINDVDE ELDQQLSAAD IAAASLASGL VARRAEPETL SDASVSPTAV 240
  241 VQQQQQQQQQ LQQPLLQSQP HFVPSSGNIL SQVTLYSGSN PSTNPCQSAV QNQGQNSNPN 300
  301 PNQNPNTNPN QNQQRCSCQP QTSPLPHIKE EEESDQANFK HQTSLKEHQP LPPPITIATG 360
  361 YCGSCESVHH SSATSSSAGT VPPGGQQTQE YIAGTSSTPS PRIKLKFRKP HKSCWSRIVL 420
  421 APIGSAGGSS SATTVIGSNS NETLASSSTT GGTATTTQNS SSVSVAAHHR LTSSSASALA 480
  481 TSHPSNSQLL PTSKMQAEQG SIGDLQKYHS RYLKNRRHTL ANVRFDVENG QGARSPLEGG 540
  541 SPSAGLVLQN LPQRRESFLY RSDSDFEMSP KSMSRNSSIA SERFKEQEAS ILVDRSHGED 600
  601 LIVTPFAQIL ASLRSVRNNL LSLTNVPASN KSRRPNQSSS ASRSGNPPGA PLSQGEEAYT 660
  661 RLATDTIEEL DWCLDQLETI QTHRSVSDMA SLKFKRMLNK ELSHFSESSR SGNQISEYIC 720
  721 STFLDKQQEF DLPSLRVEDN PELVAANAAA GQQSAGQYAR SRSPRGPPMS QISGVKRPLS 780
  781 HTNSFTGERL PTFGVETPRE NELGTLLGEL DTWGIQIFSI GEFSVNRPLT CVAYTIFQSR 840
  841 ELLTSLMIPP KTFLNFMSTL EDHYVKDNPF HNSLHAADVT QSTNVLLNTP ALEGVFTPLE 900
  901 VGGALFAACI HDVDHPGLTN QFLVNSSSEL ALMYNDESVL ENHHLAVAFK LLQNQGCDIF 960
  961 CNMQKKQRQT LRKMVIDIVL STDMSKHMSL LADLKTMVET KKVAGSGVLL LDNYTDRIQV1020
 1021 LENLVHCADL SNPTKPLPLY KRWVALLMEE FFLQGDKERE SGMDISPMCD RHNATIEKSQ1080
 1081 VGFIDYIVHP LWETWADLVH PDAQDILDTL EENRDYYQSM IPPSPPPSGV DENPQEDRIR1140
 1141 FQVTLEESDQ ENLAELEEGD ESGGESTTTG TTGTTAASAL SGAGGGGGGG GGMAPRTGGC1200
 1201 QNQPQHGGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] FFAS03 1.01 70S ribosome functional complex
    2 View Details [168..300] deduced N/A No confident structure predictions are available.
    3 View Details [301..521] MSA 6.334996 View MSA. No confident structure predictions are available.
    4 View Details [522..759] deduced N/A No confident structure predictions are available.
    5 View Details [760..1209] PSI-BLAST 141.0 No description for 2fm0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  4.70762025272187 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  4.66767157264894 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  4.40961779134517 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  3.68838886134169 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.64567538445993 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.26293733853576 bayes_pls_golite062009
  • hydrolase activity
    		•  1.17086565360856 bayes_pls_golite062009
  • catalytic activity
    		•  1.07048165010262 bayes_pls_golite062009
  • binding
    		•  0.994379083280533 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.893957699588543 bayes_pls_golite062009
  • protein binding
    		•  0.162314119157812 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle