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Protein Overview: ac-PA

General Information:
Name(s) found: ac-PA / FBpp0070071 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene achaete is referred to in FlyBase by the symbol Dmel\ac (CG3796, FBgn0000022). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:264064..264980. It has the cytological map location 1A6. There is experimental evidence that it has the molecular function</span>: protein heterodimerization activity; sequence-specific DNA binding; transcription regulator activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: bristle morphogenesis; regulation of transcription, DNA-dependent; peripheral nervous system development. 45 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: adult segment; adult mesothoracic segment; peripheral nervous system; nervous system; postalar bristle; anterior orbital bristle; external compound sense organ; acrostichal bristle; antennal segment; adult external prothorax. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 201 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: ventral cord development [NAS]
    bristle morphogenesis [IMP][NAS]
    central nervous system development [NAS][TAS]
    oogenesis [TAS]
    nervous system development [TAS]
    regulation of transcription, DNA-dependent [IDA][NAS]
    positive regulation of transcription [TAS]
    peripheral nervous system development [IMP][NAS][TAS]
    neuroblast fate determination [TAS]
    regulation of transcription [IEA]
    regulation of mitotic cell cycle [TAS]
    Molecular Function: DNA binding [IDA][TAS]
    transcription factor activity [IC][NAS]
    protein heterodimerization activity [IPI]
    transcription regulator activity [IDA]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALGSENHSV FNDDEESSSA FNGPSVIRRN ARERNRVKQV NNGFSQLRQH IPAAVIADLS  60
   61 NGRRGIGPGA NKKLSKVSTL KMAVEYIRRL QKVLHENDQQ KQKQLHLQQQ HLHFQQQQQH 120
  121 QHLYAWHQEL QLQSPTGSTS SCNSISSYCK PATSTIPGAT PPNNFHTKLE ASFEDYRNNS 180
  181 CSSGTEDEDI LDYISLWQDD L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 10.0 SREBP-1a
    2 View Details [121..201] MSA 1.287989 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.48787404513864 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.44519817693888 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • promoter binding
    		•  0.94414084000081 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle