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View Structure Prediction Details

Protein: ac-PA
Organism: Drosophila melanogaster
Length: 201 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ac-PA.

Description E-value Query
Range
Subject
Range
gi|9094, gi|103480 - gi|9094|emb|CAA44271.1| achaete [Drosophila simulans], pir||S23324 gene achaete protein - fruit fly ...
175.0 [0..1] [201..1]
gi|190648061, gi... - gi|6331091|dbj|BAA86615.1| achaete [Drosophila erecta], gi|194911842|ref|XP_001982385.1| ac [Drosoph...
171.0 [0..1] [201..1]
gi|3618325, gi|1... - gi|3618325|dbj|BAA33207.1| achaete [Drosophila yakuba], gi|195469485|ref|XP_002099668.1| achaete [Dr...
169.0 [0..1] [201..1]
gi|125981561, gi... - gi|54643095|gb|EAL31839.1| GA17691-PA [Drosophila pseudoobscura], gi|125981561|ref|XP_001354784.1| G...
139.0 [0..20] [201..24]
gi|220943410, gi... - gi|220953372|gb|ACL89229.1| sc-PA [synthetic construct], gi|220943410|gb|ACL84248.1| sc-PA [syntheti...
sc-PA - The gene scute is referred to in FlyBase by the symbol Dmel\sc (CG3827, FBgn0004170). It is a protei...
131.0 [0..18] [199..93]
gi|4566748, gi|1... - gi|4566748|gb|AAD23441.1|AF115772_1 basic helix-loop-helix transcription factor Ndr1a [Danio rerio],...
127.0 [0..4] [187..68]
gi|109066962 - gi|109066962|ref|XP_001084056.1| PREDICTED: neurogenic differentiation 6 isoform 1 [Macaca mulatta]
124.0 [0..4] [187..40]
gi|12002048 - gi|12002048|gb|AAG43167.1|AF063609_1 brain my051 protein [Homo sapiens]
123.0 [0..4] [187..74]

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Predicted Domain #1
Region A:
Residues: [1-120]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALGSENHSV FNDDEESSSA FNGPSVIRRN ARERNRVKQV NNGFSQLRQH IPAAVIADLS  60
   61 NGRRGIGPGA NKKLSKVSTL KMAVEYIRRL QKVLHENDQQ KQKQLHLQQQ HLHFQQQQQH 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 1am9A
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.44519817693888 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
promoter binding 0.94414084000081 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [121-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHLYAWHQEL QLQSPTGSTS SCNSISSYCK PATSTIPGAT PPNNFHTKLE ASFEDYRNNS  60
   61 CSSGTEDEDI LDYISLWQDD L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle