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Protein Overview: pho-PB, pho-PA

General Information:
Name(s) found: pho-PB / FBpp0088269 [FlyBase]
pho-PA / FBpp0088268 [FlyBase]
Description(s) found:
Found 37 descriptions.
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  • The gene pleiohomeotic is referred to in FlyBase by the symbol Dmel\pho (CG17743, FBgn0002521). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1193094..1202271. It has the cytological map location 102F8. There is experimental evidence that it has the molecular function</span>: chromatin DNA binding; chromatin binding; SUMO binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: gene silencing; negative regulation of gene expression; regulation of transcription; chromatin silencing. 18 alleles are reported. The phenotypes of these alleles are annotated with: unguis; antenna; sex comb; pupal abdomen. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene pleiohomeotic is referred to in FlyBase by the symbol Dmel\pho (CG17743, FBgn0002521). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1193094..1202271. It has the cytological map location 102F8. There is experimental evidence that it has the molecular function</span>: chromatin DNA binding; chromatin binding; SUMO binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: gene silencing; negative regulation of gene expression; regulation of transcription; chromatin silencing. 18 alleles are reported. The phenotypes of these alleles are annotated with: unguis; antenna; sex comb; pupal abdomen. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 520 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    polytene chromosome puff [IDA]
    nuclear chromatin [IDA]
    Ino80 complex [IDA]
    Biological Process: gene silencing [IDA][NAS]
    negative regulation of gene expression [IMP]
    chromatin silencing [IDA]
    regulation of transcription [IMP][NAS]
    Molecular Function: DNA binding [IDA][NAS][TAS]
    chromatin DNA binding [IDA]
    SUMO binding [IPI]
    transcription factor activity [NAS]
    zinc ion binding [IEA]
    chromatin binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYERFGIIL QSEQYDEDIG NTKVNQKMNE GNHYDLHRKN AFDRIIHSES KKGDNVINYN  60
   61 IHENDKIKAA DNIFSSKLKM NPNMSYEMNI NCFKNIGYGE NQETSKVLTN SLSNNDINTE 120
  121 ESGVVDKNSP FLTLGTTILN SNGKSRRWEQ KLVHIKTMEG EFSVTMWASG ISDDEYSGSD 180
  181 QIVGASDLLK GKEEFGIDGF TSQQNKEYQK MESKFTNAQT LEMPHPISSV QIMDHLIKER 240
  241 GNLSQENNIS ERILSKTTLS FEEPILLPDS SSIELVNETA AMTINNHRTL SNHTGNTGDL 300
  301 HALPSSVPFR IGLHEGQVND CLSTISQSTH QDNTDSTGCG EMNLSEVTVS YTNDKKIACP 360
  361 HKGCNKHFRD SSAMRKHLHT HGPRVHVCAE CGKAFVESSK LKRHQLVHTG EKPFQCTFEG 420
  421 CGKRFSLDFN LRTHVRIHTG DRPFVCPFDA CNKKFAQSTN LKSHILTHAK AKRNTSISGK 480
  481 SGCSNAESNS QSEDTSANYV KVELQDSVTE NHVPFVVYAD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] PSI-BLAST 53.30103 No description for 2i13A was found.
    2 View Details [236..329] PSI-BLAST 7.30103 Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
    3 View Details [330..520] PSI-BLAST 26.522879 Ying-yang 1 (yy1, zinc finger domain)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.31369346002275 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  1.53640935908107 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.0497955246512 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.912796194488319 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.240825841910931 bayes_pls_golite062009
  • histone binding
    		•  0.0619529561600476 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0129353639725593 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle