Protein Overview: heph-PO, heph-PH...

General Information:
Name(s) found:	heph-PR / FBpp0289494 [FlyBase] heph-PO / FBpp0289491 [FlyBase] heph-PH / FBpp0085240 [FlyBase]
Description(s) found: Found 36 descriptions. SHOW ALL	The gene hephaestus is referred to in FlyBase by the symbol Dmel\heph (CG31000, FBgn0011224). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27676704..27819000. It has the cytological map location 100D3-100E1. Based on sequence similarity, it is predicted to have molecular function</span>: poly-pyrimidine tract binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: spermatid development; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway. 103 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; testis; wing; individualization stage spermatid; spermatozoon. It has 22 annotated transcripts and 22 annotated polypeptides. [FlyBase] The gene hephaestus is referred to in FlyBase by the symbol Dmel\heph (CG31000, FBgn0011224). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27676704..27819000. It has the cytological map location 100D3-100E1. Based on sequence similarity, it is predicted to have molecular function</span>: poly-pyrimidine tract binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: spermatid development; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway. 103 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; testis; wing; individualization stage spermatid; spermatozoon. It has 22 annotated transcripts and 22 annotated polypeptides. [FlyBase] The gene hephaestus is referred to in FlyBase by the symbol Dmel\heph (CG31000, FBgn0011224). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27676704..27819000. It has the cytological map location 100D3-100E1. Based on sequence similarity, it is predicted to have molecular function</span>: poly-pyrimidine tract binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: spermatid development; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway. 103 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; testis; wing; individualization stage spermatid; spermatozoon. It has 22 annotated transcripts and 22 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	789 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA] ribonucleoprotein complex [IDA] cytoplasm [IDA]
Biological Process:	negative regulation of oskar mRNA translation [IMP] Notch signaling pathway [IMP] spermatid development [IMP] imaginal disc-derived wing margin morphogenesis [IMP] oocyte microtubule cytoskeleton polarization [IMP] imaginal disc-derived wing vein morphogenesis [IMP] nuclear mRNA splicing, via spliceosome [ISS]
Molecular Function:	nucleotide binding [IEA] poly-pyrimidine tract binding [ISS][NAS] translation repressor activity, nucleic acid binding [IMP] mRNA binding [ISS] mRNA 3'-UTR binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSCPIPMPM PISSLHKSEF EPVNIGVKQM QLLHAPASTH PHPHPHQHPQ HSAASAAAYQ  60
   61 AMQVHQQQHQ QQQQAAVFHH QVAAIAAQQQ QQQQQAQVQH QQQMQQQFHY QAQAQAQAQA 120
  121 MLQTYMQLQV NSAVGVSTAP ATPTKPVAAQ IPGAISGPIA GPVPVSVPTQ FFTAPSTPLT 180
  181 IIPAAAVASS AMFATAATPT SAATTPTNNR GSDELLSQAA VMAPASDNNN QDLATKKAKL 240
  241 EPGTVLAGGI AKASKVIHLR NIPNESGEAD VIALGIPFGR VTNVLVLKGK NQAFIEMADE 300
  301 ISATSMVSCY TVTPPQMRGR MVYVQFSNHR ELKTDQGHNN STAHSDYSVQ SPASGSPLPL 360
  361 SAAANATSNN ANSSSDSNSA MGILQNTSAV NAGGNTNAAG GPNTVLRVIV ESLMYPVSLD 420
  421 ILHQIFQRYG KVLKIVTFTK NNSFQALIQY PDANSAQHAK SLLDGQNIYN GCCTLRIDNS 480
  481 KLTALNVKYN NDKSRDFTNP ALPPGEPGVD IMPTAGGLMN TNDLLLIAAR QRPSLSGDKI 540
  541 VNGLGAPGVL PPFALGLGTP LTGGYNNALP NLAAFSLANS GALQTTAPAM RGYSNVLLVS 600
  601 NLNEEMVTPD ALFTLFGVYG DVQRVKILYN KKDSALIQMA EPQQAYLAMS HLDKLRLWGK 660
  661 PIRVMASKHQ AVQLPKEGQP DAGLTRDYSQ NPLHRFKKPG SKNYQNIYPP SATLHLSNIP 720
  721 SSCSEDDIKE AFTSNSFEVK AFKFFPKDRK MALLQLLSVE EAVLALIKMH NHQLSESNHL 780
  781 RVSFSKSNI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..172]	PSI-BLAST	3.154902	Sec24
2	View Details	[173..234]	deduced	N/A	No confident structure predictions are available.
3	View Details	[235..348]	PSI-BLAST	15.30103	Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
4	View Details	[349..572]	PSI-BLAST	17.30103	Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
5	View Details	[573..789]	PSI-BLAST	44.0	Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.82

Protein Overview: heph-PO, heph-PH...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: