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View Structure Prediction Details

Protein: heph-PO, heph-PH...
Organism: Drosophila melanogaster
Length: 789 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for heph-PO, heph-PH....

Description E-value Query
Range
Subject
Range
gi|114674372 - gi|114674372|ref|XP_001172084.1| PREDICTED: polypyrimidine tract-binding protein 1 [Pan troglodytes]
371.0 [0..2] [789..199]

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Predicted Domain #1
Region A:
Residues: [1-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSCPIPMPM PISSLHKSEF EPVNIGVKQM QLLHAPASTH PHPHPHQHPQ HSAASAAAYQ  60
   61 AMQVHQQQHQ QQQQAAVFHH QVAAIAAQQQ QQQQQAQVQH QQQMQQQFHY QAQAQAQAQA 120
  121 MLQTYMQLQV NSAVGVSTAP ATPTKPVAAQ IPGAISGPIA GPVPVSVPTQ FF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.154902
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [173-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAPSTPLTII PAAAVASSAM FATAATPTSA ATTPTNNRGS DELLSQAAVM APASDNNNQD  60
   61 LA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [235-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKAKLEPGT VLAGGIAKAS KVIHLRNIPN ESGEADVIAL GIPFGRVTNV LVLKGKNQAF  60
   61 IEMADEISAT SMVSCYTVTP PQMRGRMVYV QFSNHRELKT DQGHNNSTAH SDYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 2ad9A
Description: Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [349-572]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQSPASGSPL PLSAAANATS NNANSSSDSN SAMGILQNTS AVNAGGNTNA AGGPNTVLRV  60
   61 IVESLMYPVS LDILHQIFQR YGKVLKIVTF TKNNSFQALI QYPDANSAQH AKSLLDGQNI 120
  121 YNGCCTLRID NSKLTALNVK YNNDKSRDFT NPALPPGEPG VDIMPTAGGL MNTNDLLLIA 180
  181 ARQRPSLSGD KIVNGLGAPG VLPPFALGLG TPLTGGYNNA LPNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.30103
Match: 2adbA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [573-789]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAFSLANSGA LQTTAPAMRG YSNVLLVSNL NEEMVTPDAL FTLFGVYGDV QRVKILYNKK  60
   61 DSALIQMAEP QQAYLAMSHL DKLRLWGKPI RVMASKHQAV QLPKEGQPDA GLTRDYSQNP 120
  121 LHRFKKPGSK NYQNIYPPSA TLHLSNIPSS CSEDDIKEAF TSNSFEVKAF KFFPKDRKMA 180
  181 LLQLLSVEEA VLALIKMHNH QLSESNHLRV SFSKSNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 2adcA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle