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View Structure Prediction Details

Protein: heph-PO, heph-PH...
Organism: Drosophila melanogaster
Length: 789 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for heph-PO, heph-PH....

Description E-value Query
Range
Subject
Range
gi|114674372 - gi|114674372|ref|XP_001172084.1| PREDICTED: polypyrimidine tract-binding protein 1 [Pan troglodytes]
371.0 [0..2] [789..199]

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Predicted Domain #1
Region A:
Residues: [1-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSCPIPMPM PISSLHKSEF EPVNIGVKQM QLLHAPASTH PHPHPHQHPQ HSAASAAAYQ  60
   61 AMQVHQQQHQ QQQQAAVFHH QVAAIAAQQQ QQQQQAQVQH QQQMQQQFHY QAQAQAQAQA 120
  121 MLQTYMQLQV NSAVGVSTAP ATPTKPVAAQ IPGAISGPIA GPVPVSVPTQ FF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.154902
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [173-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAPSTPLTII PAAAVASSAM FATAATPTSA ATTPTNNRGS DELLSQAAVM APASDNNNQD  60
   61 LA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [235-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKAKLEPGT VLAGGIAKAS KVIHLRNIPN ESGEADVIAL GIPFGRVTNV LVLKGKNQAF  60
   61 IEMADEISAT SMVSCYTVTP PQMRGRMVYV QFSNHRELKT DQGHNNSTAH SDYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 2ad9A
Description: Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [349-572]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQSPASGSPL PLSAAANATS NNANSSSDSN SAMGILQNTS AVNAGGNTNA AGGPNTVLRV  60
   61 IVESLMYPVS LDILHQIFQR YGKVLKIVTF TKNNSFQALI QYPDANSAQH AKSLLDGQNI 120
  121 YNGCCTLRID NSKLTALNVK YNNDKSRDFT NPALPPGEPG VDIMPTAGGL MNTNDLLLIA 180
  181 ARQRPSLSGD KIVNGLGAPG VLPPFALGLG TPLTGGYNNA LPNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.30103
Match: 2adbA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [573-789]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAFSLANSGA LQTTAPAMRG YSNVLLVSNL NEEMVTPDAL FTLFGVYGDV QRVKILYNKK  60
   61 DSALIQMAEP QQAYLAMSHL DKLRLWGKPI RVMASKHQAV QLPKEGQPDA GLTRDYSQNP 120
  121 LHRFKKPGSK NYQNIYPPSA TLHLSNIPSS CSEDDIKEAF TSNSFEVKAF KFFPKDRKMA 180
  181 LLQLLSVEEA VLALIKMHNH QLSESNHLRV SFSKSNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 2adcA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle