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Protein Overview: Med-PA, FBpp0307959

General Information:
Name(s) found: FBpp0307959 [FlyBase]
Med-PA / FBpp0085176 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=3R:join(27437403..27437466,27437701..27437969,27438056..27438410,27438609..27438830,27438982..27439596,27439657..27439939,27440001..27440169,27440226..27440352,27440412..27440623); ID=FBpp0307959; name=Med-PC; parent=FBgn0011655,FBtr0337030; dbxref=REFSEQ:NP_733439,GB_protein:AAN14278,FlyBase:FBpp0307959,FlyBase_Annotation_IDs:CG1775-PC; MD5=5ce8bb4e1eb71d0c3eb019053d01787d; length=771; release=r5.56; species=Dmel; [FlyBase]
  • The gene Medea is referred to in FlyBase by the symbol Dmel\Med (CG1775, FBgn0011655). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27436787..27440927. It has the cytological map location 100C7-100D1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of developmental process; reproductive process in a multicellular organism; regulation of biological process; regionalization; stem cell differentiation; organ morphogenesis; neuron differentiation; multicellular organism reproduction; cell proliferation; positive regulation of cellular component biogenesis; dorsal/ventral axis specification. 47 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; adult segment; thoracic segment; appendage segment; adult mesothoracic segment; germarium; portion of tissue; metatarsus; cell component; midgut constriction; podocyte; t-bar; nervous system; cell cycle; synapse; imaginal precursor; spiracle; neuromuscular junction; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 771 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPI][TAS]
    transcription factor complex [IEA]
    cytoplasm [IDA]
    Biological Process: cell proliferation [IMP]
    imaginal disc-derived leg morphogenesis [IMP]
    negative regulation of salivary gland boundary specification [TAS]
    retinal ganglion cell axon guidance [IMP]
    transforming growth factor beta receptor signaling pathway [IGI][IMP][ISS][TAS]
    imaginal disc-derived wing morphogenesis [IMP]
    germ-line stem cell division [IMP][TAS]
    regulation of transcription, DNA-dependent [IEA][NAS]
    dorsal/ventral axis specification [IMP]
    neuron development [IMP]
    positive regulation of synaptic growth at neuromuscular junction [IMP]
    dorsal/ventral pattern formation [IMP]
    heart development [TAS]
    germ-line stem cell maintenance [IMP]
    BMP signaling pathway [TAS]
    ovarian follicle cell development [IMP]
    somatic stem cell maintenance [IMP]
    Molecular Function: DNA binding [TAS]
    transcription factor activity [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS]
    transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGGSGACPP AHMYGAVAPQ DIIVRDMVQM PPPPSNAPTS ADACLSIVHS LMCHRQGGES  60
   61 EGFAKRAIES LVKKLKEKRD ELDSLITAIT TNGAHPSKCV TIQRTLDGRL QVAGRKGFPH 120
  121 VIYARIWRWP DLHKNELKHV KYCAFAFDLK CDSVCVNPYH YERVVSPGID LSGLSLQSGP 180
  181 SRLVKDEYSA GPLVGSMDID GNDIGTIQHH PTQMVGPGGY GYPQGPSEYV GDANPMSAMF 240
  241 PTGRTIPKIE PQDGVAGSRG SWMVPPPPRL GQPPQQQQQQ PQQQTPQPTQ QQQAQSQAAA 300
  301 HSLPVPHGMP GMPGPMNPGP VMAPPPPPQQ AQNPQGNGVH HTQANSPTDP ASALAMQQQQ 360
  361 QQQQQQQQQQ QQQQQQSGGV PNGSVNAGGG AAAGGQYYGQ PPPVSQMQGA GGGGTSVAPS 420
  421 VHAQQNGYVS QPGSAGSAPV GGGGVFGTAQ PTPQQPQQPP TGVQANTGSA GAQAGAGGGA 480
  481 AGTWTGPNTL TYTQSMQPPD PRSLPGGFWN SSLSGDLGSP QQTPPQQQQQ QQQPRLLSRQ 540
  541 PPPEYWCSIA YFELDTQVGE TFKVPSAKPN VIIDGYVDPS GGNRFCLGAL SNVHRTEQSE 600
  601 RARLHIGKGV QLDLRGEGDV WLRCLSDNSV FVQSYYLDRE AGRTPGDAVH KIYPAACIKV 660
  661 FDLRQCHQQM HSLATNAQAA AAAQAAAVAG VANQQMGGGG RSMTAAAGIG VDDLRRLCIL 720
  721 RLSFVKGWGP DYPRQSIKET PCWIEVHLHR ALQLLDEVLH AMPIDGPRAA A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] PSI-BLAST 38.522879 Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution
    2 View Details [92..579] PSI-BLAST 41.0 No description for 1y0fB was found.
    3 View Details [580..771] PSI-BLAST 95.221849 Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  4.29887918618442 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  4.08499903551892 bayes_pls_golite062009
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • SMAD binding
    		•  3.51225744722878 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49687772656017 bayes_pls_golite062009
  • R-SMAD binding
    		•  3.48871111195275 bayes_pls_golite062009
  • protein binding
    		•  3.44553762357492 bayes_pls_golite062009
  • DNA binding
    		•  3.30334070294767 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  3.22050745190222 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.21526555447097 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.62768754625147 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  2.57320437127906 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  2.57320437127906 bayes_pls_golite062009
  • co-SMAD binding
    		•  2.55102426537309 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  2.27149407353279 bayes_pls_golite062009
  • transcription factor activity
    		•  2.08449567315174 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.78280248668052 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.70453560128155 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62015028760436 bayes_pls_golite062009
  • transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
    		•  1.61493700485683 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.3483831282689 bayes_pls_golite062009
  • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
    		•  1.2162163145467 bayes_pls_golite062009
  • transcription factor binding
    		•  0.95553719139833 bayes_pls_golite062009
  • chromatin binding
    		•  0.79443882750163 bayes_pls_golite062009
  • signal transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • promoter binding
    		•  0.67893837393425 bayes_pls_golite062009
  • ubiquitin protein ligase binding
    		•  0.457930530912821 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.33340925100096 bayes_pls_golite062009
  • histone binding
    		•  0.27452633104793 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.117374246192501 bayes_pls_golite062009
  • receptor binding
    		•  0.0581553668794451 bayes_pls_golite062009
  • identical protein binding
    		•  0.0513801649373811 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0339057097360133 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle