| Protein: | Med-PA, FBpp0307959 |
| Organism: | Drosophila melanogaster |
| Length: | 771 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Med-PA, FBpp0307959.
| Description | E-value | Query Range |
Subject Range |
|
|
541.0 | [0..1] | [771..1] |
|
Region A: Residues: [1-91] |
1 11 21 31 41 51
| | | | | |
1 MGGGSGACPP AHMYGAVAPQ DIIVRDMVQM PPPPSNAPTS ADACLSIVHS LMCHRQGGES 60
61 EGFAKRAIES LVKKLKEKRD ELDSLITAIT T
|
| Detection Method: |  |
| Confidence: | 38.522879 |
| Match: | 1ozjA |
| Description: | Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [92-579] |
1 11 21 31 41 51
| | | | | |
1 NGAHPSKCVT IQRTLDGRLQ VAGRKGFPHV IYARIWRWPD LHKNELKHVK YCAFAFDLKC 60
61 DSVCVNPYHY ERVVSPGIDL SGLSLQSGPS RLVKDEYSAG PLVGSMDIDG NDIGTIQHHP 120
121 TQMVGPGGYG YPQGPSEYVG DANPMSAMFP TGRTIPKIEP QDGVAGSRGS WMVPPPPRLG 180
181 QPPQQQQQQP QQQTPQPTQQ QQAQSQAAAH SLPVPHGMPG MPGPMNPGPV MAPPPPPQQA 240
241 QNPQGNGVHH TQANSPTDPA SALAMQQQQQ QQQQQQQQQQ QQQQQSGGVP NGSVNAGGGA 300
301 AAGGQYYGQP PPVSQMQGAG GGGTSVAPSV HAQQNGYVSQ PGSAGSAPVG GGGVFGTAQP 360
361 TPQQPQQPPT GVQANTGSAG AQAGAGGGAA GTWTGPNTLT YTQSMQPPDP RSLPGGFWNS 420
421 SLSGDLGSPQ QTPPQQQQQQ QQPRLLSRQP PPEYWCSIAY FELDTQVGET FKVPSAKPNV 480
481 IIDGYVDP
|
| Detection Method: | |
| Confidence: | 41.0 |
| Match: | 1y0fB |
| Description: | No description for 1y0fB was found. |
|
Region A: Residues: [580-771] |
1 11 21 31 41 51
| | | | | |
1 SGGNRFCLGA LSNVHRTEQS ERARLHIGKG VQLDLRGEGD VWLRCLSDNS VFVQSYYLDR 60
61 EAGRTPGDAV HKIYPAACIK VFDLRQCHQQ MHSLATNAQA AAAAQAAAVA GVANQQMGGG 120
121 GRSMTAAAGI GVDDLRRLCI LRLSFVKGWG PDYPRQSIKE TPCWIEVHLH RALQLLDEVL 180
181 HAMPIDGPRA AA
|
| Detection Method: | |
| Confidence: | 95.221849 |
| Match: | 1u7vB |
| Description: | Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transforming growth factor beta receptor, cytoplasmic mediator activity | 4.29887918618442 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase signaling protein activity | 4.08499903551892 | bayes_pls_golite062009 |
| binding | 3.6561903894619 | bayes_pls_golite062009 |
| SMAD binding | 3.51225744722878 | bayes_pls_golite062009 |
| transcription regulator activity | 3.49687772656017 | bayes_pls_golite062009 |
| R-SMAD binding | 3.48871111195275 | bayes_pls_golite062009 |
| protein binding | 3.44553762357492 | bayes_pls_golite062009 |
| DNA binding | 3.30334070294767 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | 3.22050745190222 | bayes_pls_golite062009 |
| nucleic acid binding | 3.21526555447097 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 2.62768754625147 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 2.57320437127906 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 2.57320437127906 | bayes_pls_golite062009 |
| co-SMAD binding | 2.55102426537309 | bayes_pls_golite062009 |
| type I transforming growth factor beta receptor binding | 2.27149407353279 | bayes_pls_golite062009 |
| transcription factor activity | 2.08449567315174 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.78280248668052 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.70453560128155 | bayes_pls_golite062009 |
| transcription activator activity | 1.62015028760436 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, common-partner cytoplasmic mediator activity | 1.61493700485683 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.3483831282689 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | 1.2162163145467 | bayes_pls_golite062009 |
| transcription factor binding | 0.95553719139833 | bayes_pls_golite062009 |
| chromatin binding | 0.79443882750163 | bayes_pls_golite062009 |
| signal transducer activity | 0.767071864136971 | bayes_pls_golite062009 |
| molecular transducer activity | 0.767071864136971 | bayes_pls_golite062009 |
| promoter binding | 0.67893837393425 | bayes_pls_golite062009 |
| ubiquitin protein ligase binding | 0.457930530912821 | bayes_pls_golite062009 |
| protein dimerization activity | 0.33340925100096 | bayes_pls_golite062009 |
| histone binding | 0.27452633104793 | bayes_pls_golite062009 |
| transcription repressor activity | 0.117374246192501 | bayes_pls_golite062009 |
| receptor binding | 0.0581553668794451 | bayes_pls_golite062009 |
| identical protein binding | 0.0513801649373811 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.0339057097360133 | bayes_pls_golite062009 |
