Protein Overview: Cul-5-PA

General Information:
Name(s) found:	Cul-5-PA / FBpp0084786 [FlyBase]
Description(s) found: Found 21 descriptions. SHOW ALL	The gene Cullin-5 is referred to in FlyBase by the symbol Dmel\Cul-5 (CG1401, FBgn0039632). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24884992..24888881. It has the cytological map location 98F6. Based on sequence similarity, it is predicted to have molecular function</span>: vasopressin activated calcium mobilizing receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ubiquitin-dependent protein catabolic process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	852 amino acids
Gene Ontology:
Cellular Component:	cullin-RING ubiquitin ligase complex [IEA]
Biological Process:	ubiquitin-dependent protein catabolic process [IEA]
Molecular Function:	vasopressin activated calcium mobilizing receptor activity [ISS] ubiquitin protein ligase binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRAIGKRDR DIFEEVWPDK RRIVLKLLRQ DTVSQREWQD LFFGVHFVCL WDEKGAAKIY  60
   61 DCLQQDIVEF IVQAQSQVQA QRGEQALLAT YIVEWRKFFT QSNYLPLPFR QLEQSPQVKP 120
  121 SSSGSSSSAS VSASGASTSA AAAAAATSCS GQAGKSGAST SAAAGASTSA AAAAASTSAS 180
  181 TSSAAAAAAA SGSGSSSSST STSKKNPTED SPVRKLMLDS WNKHIFHDIK HRLQESAMKI 240
  241 VHAERNGDAY DAQLVVGVRE SYVNLSSNAE DKLEIYRENF EMAYLKATVE FYRLKSAEQQ 300
  301 QENGVLAYMK YADSKLREEE VRAKRYLEPS SFSILTYTLV NVLIVDHLNS IIAECPALIR 360
  361 DYETERLNLM FRLMDRVMHG VGVEPMMGDL QRHIMSAGLA DMLSASEVIT QDSEKYVERL 420
  421 LELFNKFSDL VRNAFNDDPR FLTARDIAFK TVVNDTSVFK MELPTSIANR GVKYTAPESK 480
  481 CPELLANYCD MLLRRTPLSK RLTSEQIDAR LRDVLLVLKY VNNKDVFMRY HKVHLTRRLI 540
  541 LGTSADSEKE EDIVEWLREV GMPADYVNRL ARMFQDIKVS EDLNTQFRTS ISRHDAINIK 600
  601 ILNAGAWARC SERVSVSLPI ELEDYIPDVE EFYKKKHSGR KLQWYHHMSN GTITFVNNFG 660
  661 RYDLDVTTFQ MAVLFAWNQR QHDKISYENL RLATELPDPE LRRTLWSLVA FPKIKKQILL 720
  721 MEPAAISSPK DFAENTMFYI NQEFAIVKNG KSQRRGKLNL IGRLQLSTER SQQEDNQSIV 780
  781 QLRILRTQEA IIKIMKVRKR MNNAALQGEL IDILKNMFLP SKKMIKEQLE WLIENKYMRR 840
  841 DDDDINMFIY VA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
ubiquitin-protein ligase activity	9.47178230940453	bayes_pls_golite062009
small conjugating protein ligase activity	9.15192834197166	bayes_pls_golite062009
acid-amino acid ligase activity	8.12051073361876	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	6.87003086224111	bayes_pls_golite062009
transcription regulator activity	4.76121492612224	bayes_pls_golite062009
transcription factor activity	3.7855017556511	bayes_pls_golite062009
ligase activity	3.66453881539688	bayes_pls_golite062009
transcription repressor activity	2.39237599101586	bayes_pls_golite062009
binding	2.3219000606044	bayes_pls_golite062009
protein binding	2.20237620151495	bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity	2.15618962838168	bayes_pls_golite062009
transcription activator activity	2.05043065144612	bayes_pls_golite062009
nucleic acid binding	1.54797684894025	bayes_pls_golite062009
DNA binding	1.42215436462553	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.23862224095769	bayes_pls_golite062009
transporter activity	0.891050405674973	bayes_pls_golite062009
transmembrane transporter activity	0.648150681919233	bayes_pls_golite062009
transcription factor binding	0.612315945412079	bayes_pls_golite062009
substrate-specific transporter activity	0.368917395770011	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.249771970501337	bayes_pls_golite062009
catalytic activity	0.201606344181603	bayes_pls_golite062009
hydrolase activity	0.140191206949582	bayes_pls_golite062009
structure-specific DNA binding	0.117670813298683	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.107671044044222	bayes_pls_golite062009
transferase activity	0.064832527337659	bayes_pls_golite062009
specific transcriptional repressor activity	0.0565989703351002	bayes_pls_golite062009
sequence-specific DNA binding	0.0102780098866235	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.77

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..852]	PSI-BLAST	1000.0	Crystal Structure of The Cand1-Cul1-Roc1 Complex

Protein Overview: Cul-5-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: