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Protein Overview: Sirt7-PA

General Information:
Name(s) found: Sirt7-PA / FBpp0084733 [FlyBase]
Description(s) found:
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  • gi|24650933|ref|NP_651664.2| Sirt7 [Drosophila melanogaster] [NCBI NR]
  • gi|201065761|gb|ACH92290.1| FI05456p [Drosophila melanogaster] [NCBI NR]
  • gi|10726839|gb|AAF56851.2| Sirt7 [Drosophila melanogaster] [NCBI NR]
  • NAD-dependent protein deacetylase Sirt7 OS=Drosophila melanogaster GN=Sirt7 PE=1 SV=2 [Swiss-Prot]
  • The gene Sirt7 is referred to in FlyBase by the symbol Dmel\Sirt7 (CG11305, FBgn0039631). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24881654..24884926. It has the cytological map location 98F6. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; zinc ion binding; NAD binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein amino acid deacetylation; chromatin silencing. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG11305-PA translation from_gene[CG11305 CG11305 FBgn0039631] seq_release:3 mol_weight=88470 cds_boundaries:(3R:24,871,232..24,873,764[+]) aa_length:771 transcript_info:[CG11305-RA seq_release:3] gene_info:[gene symbol:CG11305 FBgn0039631 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VAQ1) CG11305 protein [DrosMelano7227.FASTAC.txt]
  • (AE003768) CG11305 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG11305-PA [Drosophila melanogaster]gi|24650933|ref|NP_651664.2| CG11305-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(24881866..24882030,24882251..24884401); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851; MD5=7 [fly-100309-contam.fasta]
  • CG11305-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Sirt7 CG11305-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Sirt7 [Drosophila melanogaster] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • type=protein; loc=3R:join(24881866..24882030,24882251..24884401); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851; MD5=7e3286071bd7a74113e9005e123fc54e; length=771; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(24881866..24882030,24882251..24884401); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851; MD5=7e3286071bd7a74113e9005e123fc54e; length=771; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • FI05456p OS=Drosophila melanogaster GN=Sirt7 PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(24881866..24882030,24882251..24884401); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851,FlyMine:FBpp0084733,modMine:FBpp0084733; MD5=7e3286071bd7a74113e9005e123fc54e; length=771; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(29056144..29056308,29056529..29058679); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851,FlyMine:FBpp0084733,modMine:FBpp0084733; MD5=7e3286071bd7a74113e9005e123fc54e; length=771; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(29056144..29056308,29056529..29058679); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851,FlyMine:FBpp0084733,modMine:FBpp0084733; MD5=7e3286071bd7a74113e9005e123fc54e; length=771; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0084733 type=protein; loc=3R:join(29056144..29056308,29056529..29058679); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851,FlyMine:FBpp0084733,modMine:FBpp0084733; MD5=7e3286071bd7a74113e9005e123fc54e; length=771; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(29056144..29056308,29056529..29058679); ID=FBpp0084733; name=Sirt7-PA; parent=FBgn0039631,FBtr0085364; dbxref=FlyBase:FBpp0084733,FlyBase_Annotation_IDs:CG11305-PA,GB_protein:AAF56851.2,REFSEQ:NP_651664,GB_protein:AAF56851,UniProt/Swiss-Prot:Q9VAQ1,FlyMine:FBpp0084733,modMine:FBpp0084733; MD5=7e3286071bd7a74113e9005e123fc54e; length=771; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 771 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid deacetylation [IEA]
    chromatin silencing [IEA]
    regulation of transcription [IEA]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [IEA]
    zinc ion binding [IEA]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKDLGEEKD QDQEQNTEME PKQEMDVAQS YITRAKMNPA KKDNEKRRRK DAMRRVSMIL  60
   61 RKCDSMRTTE DRQFLEKHPD MVKTTKKRKE RVEIYKERVV EREDAPHVIE AKVEQLANII 120
  121 SQAKHLVCYT GAGISTAALI PDYRGSQGIW TLLQKGQDIG EHDLSSANPT YTHMALYELH 180
  181 RRRLLHHVVS QNCDGLHLRS GLPRNSLSEI HGNMYVEVCK NCRPNSVYWR QFDTTEMTAR 240
  241 YCHKTHRLCH RCSEPLYDTI VHFGERGNVK WPLNWAGATA NAQRADVILC LGSSLKVLKK 300
  301 YTWLWQMDRP ARQRAKICVV NLQWTPKDAI ASIKINGKCD QVMAQLMHLL HIPVPVYTKE 360
  361 KDPIFAHASL LMPEELHTLT QPLLKNADEE EAFTTTTEET QDSTISSESC SFNYSDLPIG 420
  421 KGPRIRTPIK NGRRVKTNLE LRQKFKTLNG QDEEIKVEHV KTNGEVKTEK DLITLESSIK 480
  481 IETEVKLEKL ECSDTNFQQE LKLLELLPKL EPLSLKEETE ETPSNGFPEL PKLVAIQKTH 540
  541 AECLSAVPTE SRLKPLQLPP LVPIGAPLST PFVEPKLVLP PASQSSSIQI KSEGDGDSST 600
  601 ENDNEEEEES ELAQMDLLRQ NNDEELLRQL PTWYDAKYAY SGLHSILIPP PADLNIWNSQ 660
  661 VVPNFAMNRS AASCFFCFDR YAELECQFYR RWNLSQRKHK KRARSGRFVV CECCPTSDDD 720
  721 DDYDENISLA HIAAAETAKR RQQLSTSFPR KLARTQAGWY GKGYKKGRKR R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..426] PSI-BLAST 58.0 Sirt2 histone deacetylase
    2 View Details [427..564] deduced N/A No confident structure predictions are available.
    3 View Details [565..690] MSA 1.202996 View MSA. No confident structure predictions are available.
    4 View Details [691..771] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.68732752141642 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.39353160159826 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  0.875291904235447 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  0.875291904235447 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • DNA binding
    		•  0.728790202227599 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.678257037571674 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.667574326888104 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.620294268351623 bayes_pls_golite062009
  • protein binding
    		•  0.0198646008296066 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle