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Protein Overview: FBpp0311419, fkh...

General Information:
Name(s) found: FBpp0311419 [FlyBase]
fkh-PB / FBpp0289487 [FlyBase]
fkh-PA / FBpp0084690 [FlyBase]
Description(s) found:
Found 38 descriptions.
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  • type=protein; loc=3R:complement(24408743..24410275); ID=FBpp0311419; name=fkh-PD; parent=FBgn0000659,FBtr0345227; dbxref=FlyBase:FBpp0311419,FlyBase_Annotation_IDs:CG10002-PD; MD5=6760349d51af67db2f482a9621a30130; length=510; release=r5.56; species=Dmel; [FlyBase]
  • The gene fork head is referred to in FlyBase by the symbol Dmel\fkh (CG10002, FBgn0000659). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24406805..24410834. It has the cytological map location 98D5. There is experimental evidence that it has the molecular function</span>: transcription factor activity; sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: anti-apoptosis; regulation of gene-specific transcription from RNA polymerase II promoter; salivary gland development; salivary gland morphogenesis. 25 alleles are reported. The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: organ system; primordium; nervous system; embryonic nervous system; late extended germ band embryo; hemocyte; extended germ band embryo; imaginal precursor; endoderm derivative; embryonic glial cell; posterior midgut proper primordium; embryonic/larval hemocoel; embryonic stomatogastric nervous system; larval labial segment; embryonic hindgut; ectoderm derivative; cephalopharyngeal skeleton; adult segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene fork head is referred to in FlyBase by the symbol Dmel\fkh (CG10002, FBgn0000659). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24406805..24410834. It has the cytological map location 98D5. There is experimental evidence that it has the molecular function</span>: transcription factor activity; sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: anti-apoptosis; regulation of gene-specific transcription from RNA polymerase II promoter; salivary gland development; salivary gland morphogenesis. 25 alleles are reported. The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: organ system; primordium; nervous system; embryonic nervous system; late extended germ band embryo; hemocyte; extended germ band embryo; imaginal precursor; endoderm derivative; embryonic glial cell; posterior midgut proper primordium; embryonic/larval hemocoel; embryonic stomatogastric nervous system; larval labial segment; embryonic hindgut; ectoderm derivative; cephalopharyngeal skeleton; adult segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 510 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [TAS]
    ectodermal gut development [TAS]
    anti-apoptosis [IMP][TAS]
    Malpighian tubule morphogenesis [TAS]
    salivary gland boundary specification [NAS]
    regulation of transcription, DNA-dependent [IEA][ISS][NAS]
    endoderm formation [TAS]
    salivary gland development [IMP][NAS]
    regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    salivary gland morphogenesis [IMP][TAS]
    Molecular Function: transcription factor activity [IDA][ISS]
    transcription regulator activity [NAS]
    sequence-specific DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKLYAEPPP SSAPVSMASS GGGGPPSGGG GGGGGGGGGG PPPPSNNNPN PTSNGGSMSP  60
   61 LARSAYTMNS MGLPVGGMSS VSPQAAATFS SSVLDSAAAV ASMSASMSAS MSASMNASMN 120
  121 GSMGAAAMNS MGGNCMTPSS MSYASMGSPL GNMGGCMAMS AASMSAAGLS GTYGAMPPGS 180
  181 REMETGSPNS LGRSRVDKPT TYRRSYTHAK PPYSYISLIT MAIQNNPTRM LTLSEIYQFI 240
  241 MDLFPFYRQN QQRWQNSIRH SLSFNDCFVK IPRTPDKPGK GSFWTLHPDS GNMFENGCYL 300
  301 RRQKRFKDEK KEAIRQLHKS PSHSSLEATS PGKKDHEDSH HMHHHHHSRL DHHQHHKEAG 360
  361 GASIAGVNVL SAAHSKDAEA LAMLHANAEL CLSQQPQHVP THHHHQHHQL QQEELSAMMA 420
  421 NRCHPSLITD YHSSMHPLKQ EPSGYTPSSH PFSINRLLPT ESKADIKMYD MSQYAGYNAL 480
  481 SPLTNSHAAL GQDSYYQSLG YHAPAGTTSL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] FFAS03 0.97 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
    2 View Details [101..203] Pfam 22.49485 No description for PF08430.3 was found. No confident structure predictions are available.
    3 View Details [204..342] PSI-BLAST 31.39794 Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
    4 View Details [343..510] MSA 3.305991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.2723726467408 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle