Protein Overview: FBpp0300849

General Information:
Name(s) found:	FBpp0300849 [FlyBase]
Description(s) found: Found 21 descriptions. SHOW ALL	type=protein; loc=3R:join(22363345..22363506,22370765..22370882,22380079..22380661,22380955..22381373,22392083..22392297,22392646..22392948,22393010..22393089,22393199..22393467,22399576..22400183,22400302..22400502,22400573..22400759,22400887..22401170,22402079..22402363,22404443..22404553,22404824..22405003,22405366..22405524,22405611..22405824,22405900..22405988,22406055..22406348,22406418..22406744,22415630..22415780,22416163..22416439,22420498..22420537); ID=FBpp0300849; name=scrib-PD; parent=FBgn0263289,FBtr0308625; dbxref=FlyBase_Annotation_IDs:CG43398-PD,FlyBase:FBpp0300849,REFSEQ:NP_524754,GB_protein:AAF56598; MD5=8344710705f937699a897aa7d9473b10; length=1851; release=r5.56; species=Dmel; [FlyBase]
Organism:	Drosophila melanogaster
Length:	1851 amino acids
Gene Ontology:
Cellular Component:	apicolateral plasma membrane [IDA] lateral plasma membrane [IDA] subapical complex [TAS] cytoplasm [NAS] septate junction [IDA][NAS][TAS] neuromuscular junction [IDA] basolateral plasma membrane [TAS]
Biological Process:	cell proliferation [IMP] dorsal closure [IMP][TAS] establishment or maintenance of apical/basal cell polarity [IMP] wing disc morphogenesis [IMP] negative regulation of cell proliferation [TAS] positive regulation of antibacterial peptide biosynthetic process [IMP] asymmetric protein localization [IMP][TAS] establishment or maintenance of epithelial cell apical/basal polarity [NAS][TAS] negative regulation of imaginal disc growth [IMP] morphogenesis of embryonic epithelium [TAS] establishment or maintenance of polarity of embryonic epithelium [TAS] regulation of cell cycle [NAS] morphogenesis of follicular epithelium [IMP] establishment or maintenance of polarity of follicular epithelium [IMP] morphogenesis of larval imaginal disc epithelium [IMP] establishment or maintenance of polarity of larval imaginal disc epithelium [IMP] pole cell migration [NAS] cell morphogenesis [IMP] response to chemical stimulus [IMP] establishment of ommatidial planar polarity [IMP] R3/R4 cell fate commitment [IMP] olfactory behavior [IMP] compound eye development [IMP] gonad development [NAS] zonula adherens assembly [IMP][TAS] septate junction assembly [IMP] negative regulation of epithelial cell proliferation [IMP] regulation of synapse structure and activity [IMP] establishment of imaginal disc-derived wing hair orientation [IMP] morphogenesis of a polarized epithelium [TAS]
Molecular Function:	protein binding [IPI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKCIPIFKG CNRQVEFVDK RHCSLPQVPE EILRYSRTLE ELFLDANHIR DLPKNFFRLH  60
   61 RLRKLGLSDN EIGRLPPDIQ NFENLVELDV SRNDIPDIPD DIKHLQSLQV ADFSSNPIPK 120
  121 LPSGFSQLKN LTVLGLNDMS LTTLPADFGS LTQLESLELR ENLLKHLPET ISQLTKLKRL 180
  181 DLGDNEIEDL PPYLGYLPGL HELWLDHNQL QRLPPELGLL TKLTYLDVSE NRLEELPNEI 240
  241 SGLVSLTDLD LAQNLLEALP DGIAKLSRLT ILKLDQNRLQ RLNDTLGNCE NMQELILTEN 300
  301 FLSELPASIG QMTKLNNLNV DRNALEYLPL EIGQCANLGV LSLRDNKLKK LPPELGNCTV 360
  361 LHVLDVSGNQ LLYLPYSLVN LQLKAVWLSE NQSQPLLTFQ PDTDAETGEQ VLSCYLLPQQ 420
  421 EYQPITPARD LESDSEPFEE REPSRTVVKF SEEATQEKET PFVRQNTPHP KDLKAKAQKL 480
  481 KVERSRNEEH ANLVTLPEEN GTKLAETPTE TRTIANNHQQ QPHPVQQPIV GVNSKQPVVV 540
  541 GVVTPTTTTV APTGVQGGSE GASSTANNVK AATAAVVAEL AATVGGSDEV QDDDEQEDEF 600
  601 ESDRRVGFQV EGEDDDFYKR PPKLHRRDTP HHLKNKRVQH LTDKQASEIL ANALASQERN 660
  661 DTTPQHSLSG KVTSPIEEEE QLEVEQEQQQ QQQQHPFDSS LSPISAGKTA EASTDPDNLD 720
  721 GVTELRLEQY EIHIERTAAG LGLSIAGGKG STPFKGDDDG IFISRVTEAG PADLAGLKVG 780
  781 DKVIKVNGIV VVDADHYQAV QVLKACGAVL VLVVQREVTR LIGHPVFSED GSVSQISVET 840
  841 RPLVADAPPA ASISHERYIP APIEIVPQQQ HLQQQQQQPI QQVAPTHSYS GNVFATPTAA 900
  901 QTVQPAVSAA PNGLLLNGRE APLSYIQLHT TLIRDQIGQG LGFSIAGGKG SPPFKDDCDG 960
  961 IFISRITEGG LAYRDGKIMV GDRVMAINGN DMTEAHHDAA VACLTEPQRF VRLVLQREYR1020
 1021 GPLEPPTSPR SPAVLNSLSP SGYLANRPAN FSRSVVEVEQ PYKYNTLATT TPTPKPTVPA1080
 1081 SISNNNNTLP SSKTNGFATA AAATIDSSTG QPVPAPRRTN SVPMGDGDIG AGSTTSGDSG1140
 1141 EAQPSSLRPL TSDDFQAMIP AHFLSGGSQH QVHVARPNEV GVSAVTVNVN KPQPDLPMFP1200
 1201 AAPTELGRVT ETITKSTFTE TVMTRITDNQ LAEPLISEEV VLPKNQGSLG FSIIGGTDHS1260
 1261 CVPFGTREPG IFISHIVPGG IASKCGKLRM GDRILKVNEA DVSKATHQDA VLELLKPGDE1320
 1321 IKLTIQHDPL PPGFQEVLLS KAEGERLGMH IKGGLNGQRG NPADPSDEGV FVSKINSVGA1380
 1381 ARRDGRLKVG MRLLEVNGHS LLGASHQDAV NVLRNAGNEI QLVVCKGYDK SNLIHSIGQA1440
 1441 GGMSTGFNSS ASCSGGSRQG SRASETGSEL SQSQSVSSLD HEEDERLRQD FDVFASQKPD1500
 1501 AQQPTGPSVL AAAAAMVHGA SSPTPPAATS NITPLPTAAA VASADLTAPD TPATQTVALI1560
 1561 HAEQQAHQQQ QQTQLAPLGQ EKSTQEKVLE IVRAADAFTT VPPKSPSEHH EQDKIQKTTT1620
 1621 VVISKHTLDT NPTTPTTPAA PLSIAGAESA NSAGAPSPAV PASTPGSAPV LPAVAVQTQT1680
 1681 QTTSTEKDEE EESQLQSTPA SRDGAEEQQE EVRAKPTPTK VPKSVSDKKR FFESAMEDQH1740
 1741 KPTQKTDKVF SFLSKDEVEK LRQEEERKIA TLRRDKNSRL LDAANDNIDK DAAQQRTKSN1800
 1801 SNSSSGDDND DSDQEEGIAR GDSVDNAALG HFDDAEDMRN PLDEIEAVFR S

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..640]	PSI-BLAST	70.045757	The molecular structure of toll-like receptor 3 ligand binding domain
2	View Details	[641..714]	deduced	N/A	No confident structure predictions are available.
3	View Details	[715..821]	PSI-BLAST	15.154902	Na+/H+ exchanger regulatory factor, NHERF
4	View Details	[822..926]	deduced	N/A	No confident structure predictions are available.
5	View Details	[927..1030]	PSI-BLAST	23.0	Solution structure of the first PDZ domain of scribble homolog protein (hScrib)
6	View Details	[1031..1116]	deduced	N/A	No confident structure predictions are available.
7	View Details	[1117..1231]	PSI-BLAST	25.0	Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins
8	View Details	[1232..1330]	FFAS03	4.83	Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E)
9	View Details	[1331..1428]	PSI-BLAST	21.39794	Solution structure of the fourth PDZ domain of human scribble (KIAA0147 protein)
10	View Details	[1429..1611]	deduced	N/A	No confident structure predictions are available.
11	View Details	[1612..1851]	MSA	1.136996	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

4

No functions predicted.

5

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

6

No functions predicted.

7

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

8

Term	Confidence	Notes
protein binding	3.22145158985802	bayes_pls_golite062009
binding	2.49440226554254	bayes_pls_golite062009
signal transducer activity	0.892817370602462	bayes_pls_golite062009
molecular transducer activity	0.892817370602462	bayes_pls_golite062009
transporter activity	0.801614726348297	bayes_pls_golite062009
receptor binding	0.771579763169856	bayes_pls_golite062009
transmembrane transporter activity	0.708502382436949	bayes_pls_golite062009
transcription regulator activity	0.6225846026487	bayes_pls_golite062009
beta-catenin binding	0.54133173692519	bayes_pls_golite062009
PDZ domain binding	0.529933147165971	bayes_pls_golite062009
substrate-specific transporter activity	0.448136507940928	bayes_pls_golite062009
protein domain specific binding	0.412972149823917	bayes_pls_golite062009
cyclase inhibitor activity	0.352975560849784	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.352975560849784	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.258628194099861	bayes_pls_golite062009
transcription activator activity	0.105686987138254	bayes_pls_golite062009

9

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

10

No functions predicted.

11

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle