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Protein Overview: CG5728-PA

General Information:
Name(s) found: CG5728-PA / FBpp0084016 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG5728 (CG5728, FBgn0039182). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20154177..20159036. It has the cytological map location 95F12-95F13. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: regulation of alternative nuclear mRNA splicing, via spliceosome. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1430 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    nucleolus [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    rRNA processing [ISS]
    Molecular Function: mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVPNEKSFPR GGTIHSEVKT DDVSLNIVFG ASQKKVKKAP KVKENLLSYE TEEQNGQLEA  60
   61 FSAETLNMDT LQEDMLVMGV VKELTATALQ IALPGRMFAR TLVADISDAY TRVAKAAMSG 120
  121 DTSEYHDLTE LFQLGRIVYG KAIKTEKLDT GRVSLLLSLK PADVHGNLHH KSIKKGFIFS 180
  181 GAVAEALEHG YVIESGVQGL QAFVPCEKPA QKLHVGQLAF LKVKTVHHDT HQSTCTCVQV 240
  241 EQDQLRIKSQ NETNLDYILP GSIVKFKVAK HLKDGLKGSI MNESFSAYVN EHHLANALDT 300
  301 LDAYELNEDY NARVLYVMPL TKLVYLTLNL DIKTGAAVAK DQDEEEQEVE PIKVGSVVEK 360
  361 AKVLRLGSGG VVLLLNKKLK GIISYGSIRG NFKGNYDKDE VLSKYGRKTK HKVRILGYDV 420
  421 IESLYYCSDD PNVVNEKLFC LEDINAGDLV TAKIFKKDDK IKGWSVRIGK VNGILEQFYL 480
  481 APNVRYDVGQ SLKCRVLEVN AERKICYVSN RAEYLGKGIK ILTDYASAHV GNVYMGTVVR 540
  541 CEDTYVLVKF GNGIKGVLHR QNLKENSSFF EGQTTKFRIL TRNKDQITLT LPEDKFQLGE 600
  601 ICPVEITNAL DAGLEVKITF AAEDDEEDED GNPKLEEFVG LIPLRLLSDH LELLHAQMRV 660
  661 HPAGSYTDAA CIMQNIFSLR DVPYFSGQLT KDWQSVQVGD IIRSYVKHAT DQVVDLMVCV 720
  721 RNYNKPVKVH VKMLRLNAVK NAPVELVPEQ LLWVKVLSKE VETKTLTVSA KLTDVWSGDL 780
  781 SDTAKLVEGY LNEVAQIKAG LEEASAPISK YSVGEKINVV FKGIDATTND WVYTVEGNGK 840
  841 VSALLLSSLV GTAKAPEMGS KHEAVILWIE YSSDVLLISN KKLDIAHISP SGELSTNLIG 900
  901 KAGMKAKVLL KLESVAVCSL KKGTNPLVIC PIRLHPNDIE NSGSAELRQG DFCNIAFIHD 960
  961 KLHIAVPETV WRLWRGVKRT AGTEVAPVKA KKAKVEESPK QKKTTIEETS AQKKVKAKAK1020
 1021 VETKTEAKAI PTKRKAEVVE KITNGQKKTQ PLTNGIVKEK PKQNGKLFFE DKTPAKNAKS1080
 1081 ETPKSNGAEG KSRLPGVSSF WEDDVNQSKE GSSDEDEELN VAETQKNAAK KKRLSAKEKA1140
 1141 KAEIKEEQRL REIEERNADP KARLETIDQY ERLVIAQPNN SISWLKYIAF LLSNTEIEKA1200
 1201 RALARRAIST ISFRETQELR NMWSALLNME LVYSNNFDDV LKEALNCNDP LEIYISVVDI1260
 1261 LKKNKRKDRL SSVLTTVLNK FKTELRVWPV AAEAYFWLGK SDQVHNLLQR ALRALPNQEH1320
 1321 IPCIVSFAKL YAKHDNNDMA QTLLDDVVTS YPKRIDIWSV YVDMLIKAGL IDSARNVLER1380
 1381 AVVQKLKPNK MQVIYKKYLQ LEENHGTDAT VAKVKQQAEQ WVKNYAKTVK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..164] FFAS03 3.68 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    2 View Details [165..429] PSI-BLAST 16.154902 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    3 View Details [430..503] PSI-BLAST 25.30103 No description for 2oceA was found.
    4 View Details [504..686] PSI-BLAST 6.522879 Archaeal exosome core
    5 View Details [687..849] PSI-BLAST 4.69897 C-terminal domain of RNA polymerase II subunit RBP4 (RpoE); N-terminal, heterodimerisation domain of RBP4 (RpoE)
    6 View Details [850..1334] PSI-BLAST 8.39794 No description for 2ooeA was found.
    7 View Details [1335..1430] PSI-BLAST 64.09691 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  4.09009085606859 bayes_pls_golite062009
  • DNA binding
    		•  3.36845392994723 bayes_pls_golite062009
  • binding
    		•  2.75191943661749 bayes_pls_golite062009
  • RNA binding
    		•  2.27676610881755 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.87401014198878 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.83152266175242 bayes_pls_golite062009
    		• 1.76360026808806 bayes_pls_golite062009
  • structural molecule activity
    		•  1.64866802884616 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.50253120414939 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.25554419417176 bayes_pls_golite062009
  • transcription factor activity
    		•  1.23001261722207 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.96837127754605 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.96837127754605 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.968246780254221 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.889515634362309 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.852392118159292 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.807131021663582 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.753061173202428 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.567761713204349 bayes_pls_golite062009
  • mRNA binding
    		•  0.358682315244164 bayes_pls_golite062009
  • nuclease activity
    		•  0.344602655860014 bayes_pls_golite062009
  • protein binding
    		•  0.185497104009134 bayes_pls_golite062009
  • ligase activity
    		•  0.134124680390346 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.09002897694881 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.55336640491561 bayes_pls_golite062009
  • RNA binding
    		•  2.47373172667773 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.13956481798878 bayes_pls_golite062009
  • binding
    		•  1.9759530321894 bayes_pls_golite062009
  • structural molecule activity
    		•  1.95031459523051 bayes_pls_golite062009
  • DNA binding
    		•  1.83809666640016 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
    		• 1.8053217442628 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21526211005888 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.15212468568198 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.10445667068538 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.07288786419238 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.07285050275461 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.07285050275461 bayes_pls_golite062009
  • transcription termination factor activity
    		•  1.01993495617192 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.85691075793641 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.83268201349295 bayes_pls_golite062009
  • protein binding
    		•  0.523813050066193 bayes_pls_golite062009
  • mRNA binding
    		•  0.403794675006504 bayes_pls_golite062009
  • ligase activity
    		•  0.148928528645156 bayes_pls_golite062009
  • catalytic activity
    		•  0.10089766806364 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0560158842173433 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • RNA binding
    		•  5.18414740305744 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78650555542715 bayes_pls_golite062009
  • mRNA binding
    		•  3.82977088614136 bayes_pls_golite062009
  • binding
    		•  3.45962790790935 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.28364833275102 bayes_pls_golite062009
  • DNA binding
    		•  2.03207983673692 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.02605441840546 bayes_pls_golite062009
    		• 1.86852686252563 bayes_pls_golite062009
  • structural molecule activity
    		•  1.81283970647925 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30278154718684 bayes_pls_golite062009
  • protein binding
    		•  1.16541072642796 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.07288786419238 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.07285050275461 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.07285050275461 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.63404501189528 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.489176583045793 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.392035003865213 bayes_pls_golite062009
  • transcription activator activity
    		•  0.324382863054631 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.32222928997178 bayes_pls_golite062009
  • transcription factor binding
    		•  0.254024117548226 bayes_pls_golite062009
  • ligase activity
    		•  0.148928528645156 bayes_pls_golite062009
  • catalytic activity
    		•  0.113112541746059 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.1069917291606 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0321875054165348 bayes_pls_golite062009
    5
    Term Confidence Notes
  • nucleic acid binding
    		•  4.29626483284963 bayes_pls_golite062009
  • DNA binding
    		•  3.53568546959418 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.02605441840546 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.84350127337404 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • structural molecule activity
    		•  1.81283970647925 bayes_pls_golite062009
    		• 1.8053217442628 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21526211005888 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.15212468568198 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.10445667068538 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.07288786419238 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.07285050275461 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.07285050275461 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.85691075793641 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.83268201349295 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • protein binding
    		•  0.152645195799531 bayes_pls_golite062009
  • ligase activity
    		•  0.148928528645156 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
    6
    Term Confidence Notes
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10810725340025 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.03244296439384 bayes_pls_golite062009
  • DNA binding
    		•  1.77671451483154 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • transcription factor activity
    		•  1.29089764676338 bayes_pls_golite062009
  • RNA binding
    		•  1.1868411700113 bayes_pls_golite062009
  • transcription factor binding
    		•  0.498051196281179 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.24203289043804 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle