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View Structure Prediction Details

Protein: CG5728-PA
Organism: Drosophila melanogaster
Length: 1430 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG5728-PA.

Description E-value Query
Range		 Subject
Range
gi|125776020, gi... - gi|54638882|gb|EAL28284.1| GA19088 [Drosophila pseudoobscura pseudoobscura], gi|125776020|ref|XP_001...
gi|125776020|ref... - GA19088-PA [Drosophila pseudoobscura], GA19088 [Drosophila pseudoobscura pseudoobscura]
 576.0 [0..1] [1429..1]

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Predicted Domain #1
Region A:
Residues: [1-164] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVPNEKSFPR GGTIHSEVKT DDVSLNIVFG ASQKKVKKAP KVKENLLSYE TEEQNGQLEA  60
   61 FSAETLNMDT LQEDMLVMGV VKELTATALQ IALPGRMFAR TLVADISDAY TRVAKAAMSG 120
  121 DTSEYHDLTE LFQLGRIVYG KAIKTEKLDT GRVSLLLSLK PADV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.68
Match: 1e3hA
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.09009085606859 bayes_pls_golite062009
DNA binding 3.36845392994723 bayes_pls_golite062009
binding 2.75191943661749 bayes_pls_golite062009
RNA binding 2.27676610881755 bayes_pls_golite062009
transcription regulator activity 1.87401014198878 bayes_pls_golite062009
structural constituent of ribosome 1.83152266175242 bayes_pls_golite062009
1.76360026808806 bayes_pls_golite062009
structural molecule activity 1.64866802884616 bayes_pls_golite062009
structure-specific DNA binding 1.50253120414939 bayes_pls_golite062009
single-stranded DNA binding 1.25554419417176 bayes_pls_golite062009
transcription factor activity 1.23001261722207 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.96837127754605 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.96837127754605 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.968246780254221 bayes_pls_golite062009
ribonuclease activity 0.889515634362309 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.852392118159292 bayes_pls_golite062009
exoribonuclease activity 0.807131021663582 bayes_pls_golite062009
sequence-specific DNA binding 0.753061173202428 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.567761713204349 bayes_pls_golite062009
mRNA binding 0.358682315244164 bayes_pls_golite062009
nuclease activity 0.344602655860014 bayes_pls_golite062009
protein binding 0.185497104009134 bayes_pls_golite062009
ligase activity 0.134124680390346 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [165-429] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGNLHHKSIK KGFIFSGAVA EALEHGYVIE SGVQGLQAFV PCEKPAQKLH VGQLAFLKVK  60
   61 TVHHDTHQST CTCVQVEQDQ LRIKSQNETN LDYILPGSIV KFKVAKHLKD GLKGSIMNES 120
  121 FSAYVNEHHL ANALDTLDAY ELNEDYNARV LYVMPLTKLV YLTLNLDIKT GAAVAKDQDE 180
  181 EEQEVEPIKV GSVVEKAKVL RLGSGGVVLL LNKKLKGIIS YGSIRGNFKG NYDKDEVLSK 240
  241 YGRKTKHKVR ILGYDVIESL YYCSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 1e3hA
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.09002897694881 bayes_pls_golite062009
nucleic acid binding 2.55336640491561 bayes_pls_golite062009
RNA binding 2.47373172667773 bayes_pls_golite062009
structural constituent of ribosome 2.13956481798878 bayes_pls_golite062009
binding 1.9759530321894 bayes_pls_golite062009
structural molecule activity 1.95031459523051 bayes_pls_golite062009
DNA binding 1.83809666640016 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
1.8053217442628 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
transcription factor activity 1.21526211005888 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.15212468568198 bayes_pls_golite062009
exoribonuclease activity 1.10445667068538 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 1.07288786419238 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 1.07285050275461 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 1.07285050275461 bayes_pls_golite062009
transcription termination factor activity 1.01993495617192 bayes_pls_golite062009
sequence-specific DNA binding 0.85691075793641 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.83268201349295 bayes_pls_golite062009
protein binding 0.523813050066193 bayes_pls_golite062009
mRNA binding 0.403794675006504 bayes_pls_golite062009
ligase activity 0.148928528645156 bayes_pls_golite062009
catalytic activity 0.10089766806364 bayes_pls_golite062009
RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009
transcription factor binding 0.0560158842173433 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [430-503] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPNVVNEKLF CLEDINAGDL VTAKIFKKDD KIKGWSVRIG KVNGILEQFY LAPNVRYDVG  60
   61 QSLKCRVLEV NAER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.30103
Match: 2oceA
Description: No description for 2oceA was found.

Predicted Domain #4
Region A:
Residues: [504-686] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KICYVSNRAE YLGKGIKILT DYASAHVGNV YMGTVVRCED TYVLVKFGNG IKGVLHRQNL  60
   61 KENSSFFEGQ TTKFRILTRN KDQITLTLPE DKFQLGEICP VEITNALDAG LEVKITFAAE 120
  121 DDEEDEDGNP KLEEFVGLIP LRLLSDHLEL LHAQMRVHPA GSYTDAACIM QNIFSLRDVP 180
  181 YFS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 2ba0A
Description: Archaeal exosome core
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
structural constituent of ribosome 2.02605441840546 bayes_pls_golite062009
1.86852686252563 bayes_pls_golite062009
structural molecule activity 1.81283970647925 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 1.07288786419238 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 1.07285050275461 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 1.07285050275461 bayes_pls_golite062009
poly-pyrimidine tract binding 0.63404501189528 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
ligase activity 0.148928528645156 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009
RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [687-849] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQLTKDWQSV QVGDIIRSYV KHATDQVVDL MVCVRNYNKP VKVHVKMLRL NAVKNAPVEL  60
   61 VPEQLLWVKV LSKEVETKTL TVSAKLTDVW SGDLSDTAKL VEGYLNEVAQ IKAGLEEASA 120
  121 PISKYSVGEK INVVFKGIDA TTNDWVYTVE GNGKVSALLL SSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1go3E
Description: C-terminal domain of RNA polymerase II subunit RBP4 (RpoE); N-terminal, heterodimerisation domain of RBP4 (RpoE)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.29626483284963 bayes_pls_golite062009
DNA binding 3.53568546959418 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
RNA binding 2.41160981373213 bayes_pls_golite062009
structural constituent of ribosome 2.02605441840546 bayes_pls_golite062009
transcription regulator activity 1.84350127337404 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
structural molecule activity 1.81283970647925 bayes_pls_golite062009
1.8053217442628 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
transcription factor activity 1.21526211005888 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.15212468568198 bayes_pls_golite062009
exoribonuclease activity 1.10445667068538 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 1.07288786419238 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 1.07285050275461 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 1.07285050275461 bayes_pls_golite062009
sequence-specific DNA binding 0.85691075793641 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.83268201349295 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
mRNA binding 0.4162128308402 bayes_pls_golite062009
protein binding 0.152645195799531 bayes_pls_golite062009
ligase activity 0.148928528645156 bayes_pls_golite062009
RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [850-1334] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGTAKAPEMG SKHEAVILWI EYSSDVLLIS NKKLDIAHIS PSGELSTNLI GKAGMKAKVL  60
   61 LKLESVAVCS LKKGTNPLVI CPIRLHPNDI ENSGSAELRQ GDFCNIAFIH DKLHIAVPET 120
  121 VWRLWRGVKR TAGTEVAPVK AKKAKVEESP KQKKTTIEET SAQKKVKAKA KVETKTEAKA 180
  181 IPTKRKAEVV EKITNGQKKT QPLTNGIVKE KPKQNGKLFF EDKTPAKNAK SETPKSNGAE 240
  241 GKSRLPGVSS FWEDDVNQSK EGSSDEDEEL NVAETQKNAA KKKRLSAKEK AKAEIKEEQR 300
  301 LREIEERNAD PKARLETIDQ YERLVIAQPN NSISWLKYIA FLLSNTEIEK ARALARRAIS 360
  361 TISFRETQEL RNMWSALLNM ELVYSNNFDD VLKEALNCND PLEIYISVVD ILKKNKRKDR 420
  421 LSSVLTTVLN KFKTELRVWP VAAEAYFWLG KSDQVHNLLQ RALRALPNQE HIPCIVSFAK 480
  481 LYAKH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.39794
Match: 2ooeA
Description: No description for 2ooeA was found.

Predicted functions:

Term Confidence Notes
binding 2.71974493738804 bayes_pls_golite062009
transcription regulator activity 2.10810725340025 bayes_pls_golite062009
nucleic acid binding 2.03244296439384 bayes_pls_golite062009
DNA binding 1.77671451483154 bayes_pls_golite062009
protein binding 1.6279032205159 bayes_pls_golite062009
transcription factor activity 1.29089764676338 bayes_pls_golite062009
RNA binding 1.1868411700113 bayes_pls_golite062009
transcription factor binding 0.498051196281179 bayes_pls_golite062009
transcription cofactor activity 0.24203289043804 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1335-1430] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNNDMAQTLL DDVVTSYPKR IDIWSVYVDM LIKAGLIDSA RNVLERAVVQ KLKPNKMQVI  60
   61 YKKYLQLEEN HGTDATVAKV KQQAEQWVKN YAKTVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.09691
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle