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Protein Overview: pnt-PB

General Information:
Name(s) found: pnt-PB / FBpp0088658 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene pointed is referred to in FlyBase by the symbol Dmel\pnt (CG17077, FBgn0003118). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19116826..19171884. It has the cytological map location 94E10-94E13. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 16 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; organ morphogenesis; regulation of developmental process; regulation of biological process; open tracheal system development; transport; anterior/posterior axis specification; regulation of apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway; tripartite regional subdivision; regulation of cell fate specification; sensory organ development; determination of imaginal disc primordium; muscle organ development; regulation of immune system process; endocytosis. 109 alleles are reported. The phenotypes of these alleles are annotated with 91 unique terms, many of which group under: peripheral nervous system; commissure; nervous system; organ system subdivision; multi-cell-component structure; embryonic nervous system; external compound sense organ; primordium; embryonic glial cell; adult segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 718 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: epidermal growth factor receptor signaling pathway [NAS]
    R7 cell development [TAS]
    heterophilic cell-cell adhesion [NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    eye-antennal disc morphogenesis [IMP]
    regulation of transcription [ISS]
    pericardial cell differentiation [IMP]
    negative regulation of cardioblast cell fate specification [IMP]
    secondary branching, open tracheal system [IMP][TAS]
    heart development [NAS][TAS]
    primary branching, open tracheal system [IMP]
    phagocytosis, engulfment [IMP]
    anti-apoptosis [IGI]
    ovarian follicle cell development [TAS]
    torso signaling pathway [IGI]
    terminal region determination [IGI]
    regulation of hemocyte differentiation [IMP]
    peripheral nervous system development [TAS]
    regulation of transcription, DNA-dependent [IEA]
    Ras protein signal transduction [TAS]
    R3/R4 cell fate commitment [IMP]
    tracheal outgrowth, open tracheal system [IMP]
    open tracheal system development [NAS]
    muscle fiber development [IMP]
    wing disc dorsal/ventral pattern formation [IGI]
    determination of genital disc primordium [IMP]
    Molecular Function: transcription factor activity [ISS]
    protein binding [IPI]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELAICKTDL SATKFMLPPA LPSSAAIGSS SAVASTASHF LDKAAHELFQ LNAINGHLFK  60
   61 SPASSHLNSV GSPSILSQLN GIGNSGNHSG QVSTMRLKKN RKVTFLSSLV ESKNIFIKEE 120
  121 PIHGCKDLCS LSDISDHEAS LEVPTALPPL TPGTNRKVNE VLKASFASWE KEVQKCNITK 180
  181 DPREWTEEHV IYWLNWAKNE FSLVSMNLDP FYKMKGRAMV DLGKEKFLAI TPPFTGDILW 240
  241 EHLDILQKDC EKPNEDIVHG NSFESATTAS VCGSDHQVAN YPNETHANSN NSSINSRLSM 300
  301 DYVTSAGNSD NKNFHRATPH SHNGYNTSNT HDRINNSTPP QQQQSQQPTV NGSGSASSNN 360
  361 NNSMLPPAVQ QSNNENNNTS SSNTNNSSNN NNNSGGSNNS NAGSNNNNNN NNNINFMAAA 420
  421 AIFQHHLKEE PGTQNGNIGG YGGGSNSQND PTDLSSYGLP AHLAAYGGGS GSGPTGGRSS 480
  481 GGGGDESDYH STISAQDHQS QQSSGGNGSG GASGGSTGNS NGYLDSSSEF YGSYAGRNRF 540
  541 HDGYPPEFTP YDAQSFQSMG PQPTAMDQWG AAHAHQHPAA YMSTLGLDKG LLGGYTTQGG 600
  601 VPCFTGSGPI QLWQFLLELL LDKTCQSFIS WTGDGWEFKL TDPDEVARRW GIRKNKPKMN 660
  661 YEKLSRGLRY YYDKNIIHKT AGKRYVYRFV CDLQNLVGHT PEELVAKYDL KIEKKDVD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] deduced N/A No confident structure predictions are available.
    2 View Details [143..250] PSI-BLAST 39.522879 No description for 2jv3A was found.
    3 View Details [251..331] deduced N/A No confident structure predictions are available.
    4 View Details [332..550] MSA 2.260997 View MSA. No confident structure predictions are available.
    5 View Details [551..718] PSI-BLAST 46.30103 ETS-1 transcription factor, residues 331-440

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.69183445184264 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.48053910222825 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.70025468248325 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.0856082199488197 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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