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View Structure Prediction Details

Protein: pnt-PB
Organism: Drosophila melanogaster
Length: 718 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pnt-PB.

Description E-value Query
Range
Subject
Range
gi|422446, gi|393376 - pir||S33168 gene pointed protein splice form 2 - fruit fly (Drosophila melanogaster), gi|393376|emb|...
544.0 [0..1] [718..1]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELAICKTDL SATKFMLPPA LPSSAAIGSS SAVASTASHF LDKAAHELFQ LNAINGHLFK  60
   61 SPASSHLNSV GSPSILSQLN GIGNSGNHSG QVSTMRLKKN RKVTFLSSLV ESKNIFIKEE 120
  121 PIHGCKDLCS LSDISDHEAS LE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [143-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPTALPPLTP GTNRKVNEVL KASFASWEKE VQKCNITKDP REWTEEHVIY WLNWAKNEFS  60
   61 LVSMNLDPFY KMKGRAMVDL GKEKFLAITP PFTGDILWEH LDILQKDC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.522879
Match: 2jv3A
Description: No description for 2jv3A was found.

Predicted Domain #3
Region A:
Residues: [251-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKPNEDIVHG NSFESATTAS VCGSDHQVAN YPNETHANSN NSSINSRLSM DYVTSAGNSD  60
   61 NKNFHRATPH SHNGYNTSNT H

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [332-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRINNSTPPQ QQQSQQPTVN GSGSASSNNN NSMLPPAVQQ SNNENNNTSS SNTNNSSNNN  60
   61 NNSGGSNNSN AGSNNNNNNN NNINFMAAAA IFQHHLKEEP GTQNGNIGGY GGGSNSQNDP 120
  121 TDLSSYGLPA HLAAYGGGSG SGPTGGRSSG GGGDESDYHS TISAQDHQSQ QSSGGNGSGG 180
  181 ASGGSTGNSN GYLDSSSEFY GSYAGRNRFH DGYPPEFTP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [551-718]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDAQSFQSMG PQPTAMDQWG AAHAHQHPAA YMSTLGLDKG LLGGYTTQGG VPCFTGSGPI  60
   61 QLWQFLLELL LDKTCQSFIS WTGDGWEFKL TDPDEVARRW GIRKNKPKMN YEKLSRGLRY 120
  121 YYDKNIIHKT AGKRYVYRFV CDLQNLVGHT PEELVAKYDL KIEKKDVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.30103
Match: 1mdmB
Description: ETS-1 transcription factor, residues 331-440
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle