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View Structure Prediction Details

Protein: pnt-PB
Organism: Drosophila melanogaster
Length: 718 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pnt-PB.

Description E-value Query
Range
Subject
Range
gi|422446, gi|393376 - pir||S33168 gene pointed protein splice form 2 - fruit fly (Drosophila melanogaster), gi|393376|emb|...
544.0 [0..1] [718..1]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELAICKTDL SATKFMLPPA LPSSAAIGSS SAVASTASHF LDKAAHELFQ LNAINGHLFK  60
   61 SPASSHLNSV GSPSILSQLN GIGNSGNHSG QVSTMRLKKN RKVTFLSSLV ESKNIFIKEE 120
  121 PIHGCKDLCS LSDISDHEAS LE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [143-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPTALPPLTP GTNRKVNEVL KASFASWEKE VQKCNITKDP REWTEEHVIY WLNWAKNEFS  60
   61 LVSMNLDPFY KMKGRAMVDL GKEKFLAITP PFTGDILWEH LDILQKDC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.522879
Match: 2jv3A
Description: No description for 2jv3A was found.

Predicted Domain #3
Region A:
Residues: [251-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKPNEDIVHG NSFESATTAS VCGSDHQVAN YPNETHANSN NSSINSRLSM DYVTSAGNSD  60
   61 NKNFHRATPH SHNGYNTSNT H

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [332-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRINNSTPPQ QQQSQQPTVN GSGSASSNNN NSMLPPAVQQ SNNENNNTSS SNTNNSSNNN  60
   61 NNSGGSNNSN AGSNNNNNNN NNINFMAAAA IFQHHLKEEP GTQNGNIGGY GGGSNSQNDP 120
  121 TDLSSYGLPA HLAAYGGGSG SGPTGGRSSG GGGDESDYHS TISAQDHQSQ QSSGGNGSGG 180
  181 ASGGSTGNSN GYLDSSSEFY GSYAGRNRFH DGYPPEFTP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [551-718]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDAQSFQSMG PQPTAMDQWG AAHAHQHPAA YMSTLGLDKG LLGGYTTQGG VPCFTGSGPI  60
   61 QLWQFLLELL LDKTCQSFIS WTGDGWEFKL TDPDEVARRW GIRKNKPKMN YEKLSRGLRY 120
  121 YYDKNIIHKT AGKRYVYRFV CDLQNLVGHT PEELVAKYDL KIEKKDVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.30103
Match: 1mdmB
Description: ETS-1 transcription factor, residues 331-440
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle