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Protein Overview: how-PA, how-PD

General Information:
Name(s) found: how-PD / FBpp0290615 [FlyBase]
how-PA / FBpp0083575 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • The gene held out wings is referred to in FlyBase by the symbol Dmel\how (CG10293, FBgn0017397). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17867914..17905043. It has the cytological map location 94A1. There is experimental evidence that it has the molecular function</span>: mRNA 3'-UTR binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: mesodermal cell migration; apposition of dorsal and ventral imaginal disc-derived wing surfaces; somatic muscle development; embryonic development; regulation of alternative nuclear mRNA splicing, via spliceosome; mesoderm development. 53 alleles are reported. The phenotypes of these alleles are annotated with: tendon cell; dorsal closure embryo; mesoderm; wing; head; embryonic/larval somatic muscle. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • The gene held out wings is referred to in FlyBase by the symbol Dmel\how (CG10293, FBgn0017397). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17867914..17905043. It has the cytological map location 94A1. There is experimental evidence that it has the molecular function</span>: mRNA 3'-UTR binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: mesodermal cell migration; apposition of dorsal and ventral imaginal disc-derived wing surfaces; somatic muscle development; embryonic development; regulation of alternative nuclear mRNA splicing, via spliceosome; mesoderm development. 53 alleles are reported. The phenotypes of these alleles are annotated with: tendon cell; dorsal closure embryo; mesoderm; wing; head; embryonic/larval somatic muscle. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 405 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IDA][NAS]
    cytoplasm [NAS]
    Biological Process: embryonic development [IMP]
    oenocyte development [IMP]
    mesodermal cell migration [IMP]
    regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    mesoderm development [IEP]
    cell differentiation [TAS]
    axon ensheathment [IMP]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [IMP]
    somatic muscle development [IMP]
    glial cell migration [IMP]
    Molecular Function: mRNA binding [IDA][NAS]
    mRNA 3'-UTR binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVCESKAVV QQQLQQHLQQ QAAAAVVAVA QQQQAQAQAQ AQAQAQQQQQ APQVVVPMTP  60
   61 QHLTPQQQQQ STQSIADYLA QLLKDRKQLA AFPNVFTHVE RLLDEEIARV RASLFQINGV 120
  121 KKEPLTLPEP EGSVVTMNEK VYVPVREHPD FNFVGRILGP RGMTAKQLEQ ETGCKIMVRG 180
  181 KGSMRDKKKE DANRGKPNWE HLSDDLHVLI TVEDTENRAT VKLAQAVAEV QKLLVPQAEG 240
  241 EDELKKRQLM ELAIINGTYR DTTAKSVAVC DEEWRRLVAA SDSRLLTSTG LPGLAAQIRA 300
  301 PAAAPLGAPL ILNPRMTVPT TAASILSAQA APTAAFDQTG HGMIFAPYDY ANYAALAGNP 360
  361 LLTEYADHSV GAIKQQRRLA TNREHPYQRA TVGVPAKPAG FIEIQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] MSA 2.140993 View MSA. No confident structure predictions are available.
    2 View Details [144..270] PSI-BLAST 49.39794 Solution structure of the KH-QUA2 region of the Xenopus STAR-GSG Quaking protein.
    3 View Details [271..405] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nucleic acid binding
    		•  4.28581120742478 bayes_pls_golite062009
  • RNA binding
    		•  4.07234389285213 bayes_pls_golite062009
  • binding
    		•  3.45962790790935 bayes_pls_golite062009
  • mRNA binding
    		•  2.74771386314615 bayes_pls_golite062009
  • protein binding
    		•  2.21586499514642 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.01194399592256 bayes_pls_golite062009
  • DNA binding
    		•  1.78469836520678 bayes_pls_golite062009
  • transcription factor activity
    		•  0.866815968834173 bayes_pls_golite062009
    		• 0.649281624091344 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.64468203163713 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.594072241231183 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.28490151670131 bayes_pls_golite062009
  • transcription activator activity
    		•  0.210494225017032 bayes_pls_golite062009
  • transcription factor binding
    		•  0.139588254197875 bayes_pls_golite062009
  • catalytic activity
    		•  0.113112541746059 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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