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Protein Overview: Eip93F-PA

General Information:
Name(s) found: Eip93F-PA / FBpp0083567 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Eip93F is referred to in FlyBase by the symbol Dmel\Eip93F (CG18389, FBgn0013948). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17774836..17837910. It has the cytological map location 93F14. It is reported to have molecular function</span>: DNA binding; transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: activation of caspase activity; induction of apoptosis by hormones; autophagic cell death; autophagy; salivary gland cell autophagic cell death. 16 alleles are reported. The phenotypes of these alleles are annotated with: pupa; larval salivary gland; salivary gland; dorsal mesothoracic disc; embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1165 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome [NAS][TAS]
    nucleus [NAS][TAS]
    Biological Process: induction of apoptosis by hormones [IMP]
    larval midgut histolysis [TAS]
    phagocytosis, engulfment [TAS]
    positive regulation of transcription, DNA-dependent [TAS]
    autophagy [IMP]
    autophagic cell death [IEP][TAS]
    salivary gland cell autophagic cell death [IEP][NAS]
    ecdysone-mediated induction of salivary gland cell autophagic cell death [TAS]
    activation of caspase activity [IMP]
    regulation of transcription [NAS]
    Molecular Function: DNA binding [IEA][NAS]
    transcription factor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHISSYEISL ERVAEECMGR RQWKHYQDKL TCSHLNIEEQ QPIAIAGSED EPSQYNHSSK  60
   61 EISQSNPNHC KTENHRLEQQ HNGSQLLEEE DSENNQTSHD SSRTPTPGAT STPSPPPEPI 120
  121 DWRPSAKCNF CVNGRLLTVN AQGKLVAESA ATATSSSTSN SHIHQHDSDS NSSASLPHHI 180
  181 SSSSSSNNNS SGNRARHIAA ASARATPAAA TPANSLELYK LLTQRAAKMT SMDSMAAQLA 240
  241 QFSLLADFNL INSLASQQQQ QQQQQIASAV TPTTSEVSAA AISPALKDTP SPSVDAPLDL 300
  301 SSKPSPNSSI SGDVKSVRAC ATPTPSGRRA YSEEDLSRAL QDVVANKLDA RKSASQHHEQ 360
  361 RSILDNRLFK MKHHDQEQDH DGDELEDSND DAEAEVDSNA STPVYPAEFA RAQLRKLSHL 420
  421 SEHNGSDLGE DVDRGSPKMG RHPACGNASA NQGAPPSIPL DANVLLHTLM LAAGIGAMPK 480
  481 LDETQTVGDF IKGLLVANSG GIMNEGLLNL LSASQENSNG NASLLLQQQQ HQQHHQQHHQ 540
  541 QQQQQQHVAA YRHRLPKSET PETNSSLDPN DASEDPILKI PSFKVSGPAS SSSLSPGGLV 600
  601 GGHHHPLNNN NSLSISNNSN HSSNSHRNGS NRSPHSASPM LAAAVAQGGY SAGNSLLTSS 660
  661 SSSIQKMMAS NIQRQINEQS GQESLRNGNV SDCSSNNGGS SSLGYKKPSI SVAKIIGGTD 720
  721 TSRFGASPNL LSQQHHSAHH LTHQQQQQQL SAQEALGKGT RPKRGKYRNY DRDSLVEAVK 780
  781 AVQRGEMSVH RAGSYYGVPH STLEYKVKER HLMRPRKREP KPQPDLVGLT GPANKLQLDK 840
  841 LKAGPHGGSK LSNALKNQNN QAAAAAAAAA AAAAAATPNG LKLPLFEAGP QALSFQPNMF 900
  901 WPQTNATNAY GLDFNRITEA MRNPQASNHH GLMKSAQDMV ENVYDGIIRK TLQASEGNGS 960
  961 AAGNGSNGSN GNGHGHGHGH GHALLDQLLV KKTPLPFTNH RNNDYAATCS SASGESVKRS1020
 1021 GSPMGNYADI KRERLSADSG GSSDEEHSAS HINNNNSDLA HNKNKSGGGG GGGGNGQTNG1080
 1081 NGRSSRMTSR DDSETDASSL KSGESGGQQN HKMMDLNGGS SSSSHIKCES EAATGHHSPG1140
 1141 HHTTSILHEK LAQIKAEQVD QADQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..159] deduced N/A No confident structure predictions are available.
    2 View Details [160..398] deduced N/A No confident structure predictions are available.
    3 View Details [399..573] deduced N/A No confident structure predictions are available.
    4 View Details [574..758] MSA 6.236997 View MSA. No confident structure predictions are available.
    5 View Details [759..889] PSI-BLAST 14.30103 Solution structures of the HTH domain of human LCoR protein
    6 View Details [890..977] deduced N/A No confident structure predictions are available.
    7 View Details [978..1052] deduced N/A No confident structure predictions are available.
    8 View Details [1053..1165] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.13444271681002 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle