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Protein Overview: lbe-PA

General Information:
Name(s) found: lbe-PA / FBpp0083490 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene ladybird early is referred to in FlyBase by the symbol Dmel\lbe (CG6545, FBgn0011278). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17267314..17272042. It has the cytological map location 93E1. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; muscle organ development; regulation of developmental process; regulation of biological process; neuron differentiation; cellular component movement; regulation of neurogenesis; regulation of metabolic process; cell motility; regulation of cell fate specification; muscle cell differentiation; organ morphogenesis; system development; dendrite morphogenesis. 7 alleles are reported. The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: organ system; adult abdominal myoblast; adult; embryonic/larval hypodermal muscle; multi-cell-component structure; nervous system; abdominal segment 7; peripheral nervous system; abdominal oblique muscle; embryonic neuron. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 479 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    Biological Process: regulation of cell fate specification [IMP]
    genital disc morphogenesis [IMP]
    epidermis development [IMP]
    myoblast fusion [IGI]
    regulation of transcription, DNA-dependent [IEA][ISS]
    regulation of neuron differentiation [IMP]
    neuron development [IMP]
    regulation of transcription [IEA][IMP]
    mesodermal cell fate specification [TAS]
    dendrite morphogenesis [IMP]
    muscle organ development [IMP][TAS]
    heart development [TAS]
    central nervous system development [NAS]
    skeletal muscle tissue development [IGI]
    cell migration [IGI]
    Molecular Function: transcription factor activity [ISS][NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCPPTMRPA SPAESEISVG GAPSPLPTQH HTHPHSHPHP LQHPRASTID LLQQQQLLMQ  60
   61 HHAAAAAAAA AAASGLTRSA VGNLPEDYFH PLKRLRMSSS SSEPRDHTPS PPSAVPEPQT 120
  121 NQTTKSAIEG VKSFSIADIL GHSEKQREES VSPPPNANLL APPASRPIAP SGGLLQPRTE 180
  181 PLDVHPAAAA AMLLPSGQIV RPWDHLLGPT MPVRPFIPSA LLHYEQRLAL DYHRQLQEHF 240
  241 NAQAQLLRHM GMNPAIIASE DGSSERSQRS SSSNGSTECC SPRQAEKLEK LTTQEGSEEA 300
  301 QKKKSEEQPT GSGKSNGDTP LDALFQMTTK DFDESQDKSH LDIFSNRPQP KKKRKSRTAF 360
  361 TNHQIFELEK RFLYQKYLSP ADRDEIAASL GLSNAQVITW FQNRRAKQKR DIEELKKDFD 420
  421 SVKVFSAHKS FLENVNDLSI LKKKPMHESD MVGLAAAAAA AGMVVPVPGS VPMGGAPPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..195] MSA 12.239997 View MSA. No confident structure predictions are available.
    2 View Details [196..311] deduced N/A No confident structure predictions are available.
    3 View Details [312..479] PSI-BLAST 18.154902 Homeobox protein hox-b1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.35

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle