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View Structure Prediction Details

Protein: lbe-PA
Organism: Drosophila melanogaster
Length: 479 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lbe-PA.

Description E-value Query
Range
Subject
Range
gi|54657094 - gi|54657094|gb|EAL35927.1| DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain [Cryptosporidiu...
gi|67597591 - gi|67597591|ref|XP_666157.1| DNA-directed RNA polymerase II largest chain [Cryptosporidium hominis T...
146.0 [0..8] [232..1669]

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Predicted Domain #1
Region A:
Residues: [1-195]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCPPTMRPA SPAESEISVG GAPSPLPTQH HTHPHSHPHP LQHPRASTID LLQQQQLLMQ  60
   61 HHAAAAAAAA AAASGLTRSA VGNLPEDYFH PLKRLRMSSS SSEPRDHTPS PPSAVPEPQT 120
  121 NQTTKSAIEG VKSFSIADIL GHSEKQREES VSPPPNANLL APPASRPIAP SGGLLQPRTE 180
  181 PLDVHPAAAA AMLLP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [196-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGQIVRPWDH LLGPTMPVRP FIPSALLHYE QRLALDYHRQ LQEHFNAQAQ LLRHMGMNPA  60
   61 IIASEDGSSE RSQRSSSSNG STECCSPRQA EKLEKLTTQE GSEEAQKKKS EEQPTG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [312-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGKSNGDTPL DALFQMTTKD FDESQDKSHL DIFSNRPQPK KKRKSRTAFT NHQIFELEKR  60
   61 FLYQKYLSPA DRDEIAASLG LSNAQVITWF QNRRAKQKRD IEELKKDFDS VKVFSAHKSF 120
  121 LENVNDLSIL KKKPMHESDM VGLAAAAAAA GMVVPVPGSV PMGGAPPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle