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View Structure Prediction Details

Protein: lbe-PA
Organism: Drosophila melanogaster
Length: 479 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lbe-PA.

Description E-value Query
Range
Subject
Range
gi|54657094 - gi|54657094|gb|EAL35927.1| DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain [Cryptosporidiu...
gi|67597591 - gi|67597591|ref|XP_666157.1| DNA-directed RNA polymerase II largest chain [Cryptosporidium hominis T...
146.0 [0..8] [232..1669]

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Predicted Domain #1
Region A:
Residues: [1-195]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCPPTMRPA SPAESEISVG GAPSPLPTQH HTHPHSHPHP LQHPRASTID LLQQQQLLMQ  60
   61 HHAAAAAAAA AAASGLTRSA VGNLPEDYFH PLKRLRMSSS SSEPRDHTPS PPSAVPEPQT 120
  121 NQTTKSAIEG VKSFSIADIL GHSEKQREES VSPPPNANLL APPASRPIAP SGGLLQPRTE 180
  181 PLDVHPAAAA AMLLP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [196-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGQIVRPWDH LLGPTMPVRP FIPSALLHYE QRLALDYHRQ LQEHFNAQAQ LLRHMGMNPA  60
   61 IIASEDGSSE RSQRSSSSNG STECCSPRQA EKLEKLTTQE GSEEAQKKKS EEQPTG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [312-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGKSNGDTPL DALFQMTTKD FDESQDKSHL DIFSNRPQPK KKRKSRTAFT NHQIFELEKR  60
   61 FLYQKYLSPA DRDEIAASLG LSNAQVITWF QNRRAKQKRD IEELKKDFDS VKVFSAHKSF 120
  121 LENVNDLSIL KKKPMHESDM VGLAAAAAAA GMVVPVPGSV PMGGAPPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle