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Protein Overview: lbl-PA

General Information:
Name(s) found: lbl-PA / FBpp0083491 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene ladybird late is referred to in FlyBase by the symbol Dmel\lbl (CG6570, FBgn0008651). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17235701..17259845. It has the cytological map location 93E1. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: myoblast fusion; genital disc morphogenesis; regulation of neuron differentiation; skeletal muscle tissue development; regulation of transcription; cell migration; epidermis development; regulation of cell fate specification. 8 alleles are reported. The phenotypes of these alleles are annotated with: prothoracic segmental nerve; central nervous system; intersegmental nerve; dorsal denticle; EL neuron. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 372 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    Biological Process: regulation of cell fate specification [IMP]
    genital disc morphogenesis [IMP]
    epidermis development [IMP]
    myoblast fusion [IGI]
    regulation of transcription, DNA-dependent [IEA]
    regulation of neuron differentiation [IMP]
    regulation of transcription [IEA][IMP][ISS]
    mesodermal cell fate specification [TAS]
    muscle organ development [TAS]
    heart development [TAS]
    central nervous system development [NAS]
    skeletal muscle tissue development [IGI]
    cell migration [IGI]
    Molecular Function: transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQRTPSPAN SDVSVGSPSP PPLRSLNMKR LRLLRSPISL EHDRQKSSPV RVKSFSIADI  60
   61 LGRGHEEDRV EKKPERIAIP NALPGVPAPL ALINERLQIP LVPNCPPPAA LHTFLSPALL 120
  121 HSYEQRLAWD YQRQLQEHFQ AQAQLLRQMT LNPAIIASED GSSERSQRSS SSNGSTECCS 180
  181 PTQAEKVEKR SQEDRMEVPK KSPEEQPKGA SKSSGDTPLD ALFQLSTKNF DEEQDPATLN 240
  241 IFATRSNPKK KRKSRTAFTN QQIFELEKRF LYQKYLSPAD RDEIAGGLGL SNAQVITWFQ 300
  301 NRRAKLKRDM EELKKDVQCE KMSANQSFLK NVNDLTILKT RPVSRSQSLA PQPPTLPPAT 360
  361 PALRTHAEHR IG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] MSA 5.510997 View MSA. No confident structure predictions are available.
    2 View Details [132..210] deduced N/A No confident structure predictions are available.
    3 View Details [211..372] PSI-BLAST 24.0 Homeobox protein hox-b1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  0.876241359231159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle