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View Structure Prediction Details

Protein: lbl-PA
Organism: Drosophila melanogaster
Length: 372 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lbl-PA.

Description E-value Query
Range
Subject
Range
gi|1731969 - gi|1731969|emb|CAA70057.1| ladybird late homeodomain transcription factor [Drosophila melanogaster]
177.0 [0..1] [372..1]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQRTPSPAN SDVSVGSPSP PPLRSLNMKR LRLLRSPISL EHDRQKSSPV RVKSFSIADI  60
   61 LGRGHEEDRV EKKPERIAIP NALPGVPAPL ALINERLQIP LVPNCPPPAA LHTFLSPALL 120
  121 HSYEQRLAWD Y

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRQLQEHFQA QAQLLRQMTL NPAIIASEDG SSERSQRSSS SNGSTECCSP TQAEKVEKRS  60
   61 QEDRMEVPKK SPEEQPKGA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [211-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKSSGDTPLD ALFQLSTKNF DEEQDPATLN IFATRSNPKK KRKSRTAFTN QQIFELEKRF  60
   61 LYQKYLSPAD RDEIAGGLGL SNAQVITWFQ NRRAKLKRDM EELKKDVQCE KMSANQSFLK 120
  121 NVNDLTILKT RPVSRSQSLA PQPPTLPPAT PALRTHAEHR IG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle