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View Structure Prediction Details

Protein: lbl-PA
Organism: Drosophila melanogaster
Length: 372 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lbl-PA.

Description E-value Query
Range
Subject
Range
gi|1731969 - gi|1731969|emb|CAA70057.1| ladybird late homeodomain transcription factor [Drosophila melanogaster]
177.0 [0..1] [372..1]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQRTPSPAN SDVSVGSPSP PPLRSLNMKR LRLLRSPISL EHDRQKSSPV RVKSFSIADI  60
   61 LGRGHEEDRV EKKPERIAIP NALPGVPAPL ALINERLQIP LVPNCPPPAA LHTFLSPALL 120
  121 HSYEQRLAWD Y

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRQLQEHFQA QAQLLRQMTL NPAIIASEDG SSERSQRSSS SNGSTECCSP TQAEKVEKRS  60
   61 QEDRMEVPKK SPEEQPKGA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [211-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKSSGDTPLD ALFQLSTKNF DEEQDPATLN IFATRSNPKK KRKSRTAFTN QQIFELEKRF  60
   61 LYQKYLSPAD RDEIAGGLGL SNAQVITWFQ NRRAKLKRDM EELKKDVQCE KMSANQSFLK 120
  121 NVNDLTILKT RPVSRSQSLA PQPPTLPPAT PALRTHAEHR IG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle