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Protein Overview: e-PA

General Information:
Name(s) found: e-PA / FBpp0083505 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene ebony is referred to in FlyBase by the symbol Dmel\e (CG3331, FBgn0000527). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17055552..17062900. It has the cytological map location 93C7-93D1. There is experimental evidence that it has the molecular function</span>: beta-alanyl-dopamine synthase activity. There is experimental evidence that it is involved in the biological process</span>: cuticle pigmentation; chitin-based cuticle tanning; dopamine metabolic process; negative regulation of melanin biosynthetic process; histamine metabolic process; amino acid adenylylation by nonribosomal peptide synthase. 49 alleles are reported. The phenotypes of these alleles are annotated with: trident; retina; embryonic/larval spiracle; adult cuticle; wing; synaptic vesicle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 879 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: cuticle pigmentation [IGI][IMP]
    negative regulation of melanin biosynthetic process [IMP]
    developmental pigmentation [TAS]
    dopamine metabolic process [IDA]
    chitin-based cuticle tanning [IMP]
    amino acid adenylylation by nonribosomal peptide synthase [IDA]
    locomotor rhythm [NAS]
    pigment metabolic process [TAS]
    melanin biosynthetic process from tyrosine [TAS]
    circadian rhythm [NAS]
    histamine metabolic process [IMP]
    Molecular Function: beta-alanyl-dopamine synthase activity [IDA][IMP][TAS]
    cofactor binding [IEA]
    acyl carrier activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSLPQLSIV KGLQQDFVPR ALHRIFEEQQ LRHADKVALI YQPSTTGQGM APSQSSYRQM  60
   61 NERANRAARL LVAETHGRFL QPNSDGDFIV AVCMQPSEGL VTTLLAIWKA GGAYLPIDPS 120
  121 FPANRIHHIL LEAKPTLVIR DDDIDAGRFQ GTPTLSTTEL YAKSLQLAGS NLLSEEMLRG 180
  181 GNDHIAIVLY TSGSTGVPKG VRLPHESILN RLQWQWATFP YTANEAVSVF KTALTFVDSI 240
  241 AELWGPLMCG LAILVVPKAV TKDPQRLVAL LERYKIRRLV LVPTLLRSLL MYLKMEGGGA 300
  301 AQKLLYNLQI WVCSGEPLSV SLASSFFDYF DEGVHRLYNF YGSTEVLGDV TYFACESKKQ 360
  361 LSLYDNVPIG IPLSNTVVYL LDADYRPVKN GEIGEIFASG LNLAAGYVNG RDPERFLENP 420
  421 LAVEKKYARL YRTGDYGSLK NGSIMYEGRT DSQVKIRGHR VDLSEVEKNV AELPLVDKAI 480
  481 VLCYHAGQVD QAILAFVKLR DDAPMVTEMQ MEARLKDKLA DYMTPQVVIL EHVPLLVNGK 540
  541 VDRQALLKTY ETANNNEGDS SIVLDFDYSQ VPEDLKLTAR DLFETVGGVI GRSTRATLAP 600
  601 HSNFYELGGN SLNSIFTVTL LREKGYNIGI SEFIAAKNLG EIIEKMAANH DAVQLEEESL 660
  661 NACPHLKMEA VPLRLEHRQE VIDIIVASFY NKADLEQWLK PGVLRTDYSD ILNDIWNVLV 720
  721 ERDLSFVVYD TNTDRIIGTA LNFDARNEPE VDIKSKLLIV FEFLEFCEGP IRDNYLPKGL 780
  781 NQILHSFMMG TAEKLNPREN IACMHFMEHE VLRVAREKQF AGIFTTNTSP LTQQLADVYH 840
  841 YKTLLNFQVN EYVHSDGSRP FGDAPDEQRA IVHWKEVGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..565] PSI-BLAST 115.0 Phenylalanine activating domain of gramicidin synthetase 1
    2 View Details [566..659] PSI-BLAST 13.154902 No description for 2gdwA was found.
    3 View Details [660..879] PSI-BLAST 10.69897 VibH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity
    		•  5.90438437233818 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  4.4819902512335 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  4.48129067128523 bayes_pls_golite062009
  • fatty acid ligase activity
    		•  3.10420612952117 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  2.89129353633634 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  2.84227244567785 bayes_pls_golite062009
  • CoA-ligase activity
    		•  2.5960476232329 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • binding
    		•  0.891362449667197 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.742384980534643 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0862069150168795 bayes_pls_golite062009
    2
    Term Confidence Notes
  • acyl carrier activity
    		•  3.10595395492178 bayes_pls_golite062009
  • binding
    		•  1.13349407683239 bayes_pls_golite062009
  • catalytic activity
    		•  0.037428828577411 bayes_pls_golite062009
    3
    Term Confidence Notes
  • dihydrolipoamide S-acyltransferase activity
    		•  4.95288540231937 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  4.825154128623 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  4.79325739487657 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  4.44987112475286 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.08588280042054 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.027770031317 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  3.02354522717247 bayes_pls_golite062009
  • S-succinyltransferase activity
    		•  3.02354522717247 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  2.50610942105142 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  2.43159394927614 bayes_pls_golite062009
  • ligase activity
    		•  2.34510379638968 bayes_pls_golite062009
  • carnitine O-acyltransferase activity
    		•  2.07401053954424 bayes_pls_golite062009
  • acetyltransferase activity
    		•  2.00891466032088 bayes_pls_golite062009
  • transferase activity
    		•  1.78692523095641 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  0.797801402758281 bayes_pls_golite062009
  • binding
    		•  0.788999584656706 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  0.731328511162172 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  0.69903206436468 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  0.69903206436468 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  0.651721897180987 bayes_pls_golite062009
  • succinyltransferase activity
    		•  0.271602729407812 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  0.203430690130141 bayes_pls_golite062009
  • palmitoyltransferase activity
    		•  0.200750596708501 bayes_pls_golite062009
  • protein binding
    		•  0.104367069798378 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  0.0500725150648709 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle