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Protein Overview: SNF4Agamma-PF, S...

General Information:
Name(s) found: SNF4Agamma-PS / FBpp0290804 [FlyBase]
SNF4Agamma-PR / FBpp0290803 [FlyBase]
SNF4Agamma-PF / FBpp0083423 [FlyBase]
Description(s) found:
Found 38 descriptions.
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  • The gene SNF4/AMP-activated protein kinase gamma subunit is referred to in FlyBase by the symbol Dmel\SNF4AÃ?&#142;Ã?³ (CG17299, FBgn0025803). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16966463..17038409. It has the cytological map location 93C1-93C5. Based on sequence similarity, it is predicted to have molecular function</span>: AMP-activated protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of cell cycle; cholesterol homeostasis. 51 alleles are reported. The phenotypes of these alleles are annotated with: adult central complex; trichogen cell; adult central nervous system; tormogen cell; adult brain. It has 16 annotated transcripts and 16 annotated polypeptides. [FlyBase]
  • The gene SNF4/AMP-activated protein kinase gamma subunit is referred to in FlyBase by the symbol Dmel\SNF4AÃ?&#142;Ã?³ (CG17299, FBgn0025803). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16966463..17038409. It has the cytological map location 93C1-93C5. Based on sequence similarity, it is predicted to have molecular function</span>: AMP-activated protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of cell cycle; cholesterol homeostasis. 51 alleles are reported. The phenotypes of these alleles are annotated with: adult central complex; trichogen cell; adult central nervous system; tormogen cell; adult brain. It has 16 annotated transcripts and 16 annotated polypeptides. [FlyBase]
  • The gene SNF4/AMP-activated protein kinase gamma subunit is referred to in FlyBase by the symbol Dmel\SNF4AÃ?&#142;Ã?³ (CG17299, FBgn0025803). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16966463..17038409. It has the cytological map location 93C1-93C5. Based on sequence similarity, it is predicted to have molecular function</span>: AMP-activated protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of cell cycle; cholesterol homeostasis. 51 alleles are reported. The phenotypes of these alleles are annotated with: adult central complex; trichogen cell; adult central nervous system; tormogen cell; adult brain. It has 16 annotated transcripts and 16 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1400 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: positive regulation of cell cycle [IGI]
    protein amino acid phosphorylation [ISS]
    cholesterol homeostasis [IMP]
    Molecular Function: AMP-activated protein kinase activity [ISS][NAS]
    protein serine/threonine kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATNCDFIEQ PVKQQPLANA PVMGVQEDKA QEPKELPDEP AKQPDGQPYQ HFAGEDSFEC  60
   61 AFESTMDDLE QGVLDGYESD SEASANDQIT DSASSGSLGQ LAQQQQREER LRGLPGPLHG 120
  121 QHIDSEMLKC MPRSNSFDFH SSSGSSSDDE DDPDDDDDDQ VHHSLGLSLS GKFVKVDLYS 180
  181 GHQRPGYLLP PYIERRRLSQ CKEEDDEDEG DRTQLGGGSS STGESTKSEK ASKAPPRPPT 240
  241 PQDEASKEKF KDLERLRQQF MHKIDRINTR NIEESEAPPP PPPPPPPIPA TILPKALKAL 300
  301 LHTQEPVAPP SRPSPVGPPS PAPTSSVIVA KETPVPVTPE PVSPLPLPTE PPLIIKGKFK 360
  361 VTLAQETPEL RVEAQKLSKL NASSNAHTIS FPSSFGGYSS VQGLFSQRYG SNRFPTAAPH 420
  421 MSKQFFEPSL VEIRTPAQSN VALNTTGLAN SNHQSLTCDT NSLANKPRTP SERELDEIWI 480
  481 RRQDGGLSGT AAPGAPGAPL PLLQQQQQQQ RPVSLGGAST MPRLLRSESS ASTTSPSRQL 540
  541 TNSGSVSVSV SDDEQDGSLG GAGRMPGSRP SSAPAEPNAK AAKKAYKKME KEQRRQEKEQ 600
  601 SRREKEARKL ERETARRNER EAAKLEKINR HSEKISRSTE RMAMAGVGSR SGSLERRRSG 660
  661 EDSPVLNQST VHGIASPNRR PTIFDVFRPR AKSDAKRQKE KHLLDPSSAD SSATSSTYSV 720
  721 SGGTGPATSS AAGGAGGAAA AAGQGAAGGA GGLMNSMKVA MQNFSHRQHP AVTITSADGT 780
  781 QSTAKSKYKD GSAHPHQGSD AQYYHTVTAV RPNSSQRSPM TKVMDLFRHR SSSVVSEADK 840
  841 RKARAAAHQQ QLAVQSAHMR RASADLEKRR ASVGAAGRGL RGDGTLDPHH AAILFRDSRG 900
  901 LPVADPFLEK VNLSDLEEDD SQIFVKFFRF HKCYDLIPTS AKLVVFDTQL LVKKAFYALV 960
  961 YNGVRAAPLW DSEKQQFVGM LTITDFIKIL QMYYKSPNAS MEQLEEHKLD TWRSVLHNQV1020
 1021 MPLVSIGPDA SLYDAIKILI HSRIHRLPVI DPATGNVLYI LTHKRILRFL FLYINELPKP1080
 1081 AYMQKSLREL KIGTYNNIET ADETTSIITA LKKFVERRVS ALPLVDSDGR LVDIYAKFDV1140
 1141 INLAAEKTYN DLDVSLRKAN EHRNEWFEGV QKCNLDESLY TIMERIVRAE VHRLVVVDEN1200
 1201 RKVIGIISLS DILLYLVLRP SGEGVGGSES SLRASDPVLL RKVAEVEIPA TAAAATTTTP1260
 1261 PRSPSAGSGN RSLIEDIPEE ETAPARSDDA DSDNNKSASE DKANNNQHDQ TTTAATANGD1320
 1321 SNNSPVEVSF ADEAQEEEAA DQVERSNCDD DDQPALAEIE RKNASMDDDE DDGMSSAVSA1380
 1381 ASALGQSLTP AAQEMALVSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..172] MSA 1.17399 View MSA. No confident structure predictions are available.
    2 View Details [173..259] deduced N/A No confident structure predictions are available.
    3 View Details [260..382] MSA 2.196995 View MSA. No confident structure predictions are available.
    4 View Details [383..631] deduced N/A No confident structure predictions are available.
    5 View Details [632..888] deduced N/A No confident structure predictions are available.
    6 View Details [889..1018] PSI-BLAST 84.522879 No description for 2v8qE was found.
    7 View Details [1019..1400] PSI-BLAST 125.0 Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • phosphorylase kinase regulator activity
    		•  8.18623772563485 bayes_pls_golite062009
  • AMP-activated protein kinase activity
    		•  7.98159515020845 bayes_pls_golite062009
  • cAMP-dependent protein kinase inhibitor activity
    		•  7.37900747121671 bayes_pls_golite062009
  • cAMP-dependent protein kinase regulator activity
    		•  2.72879349930537 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.65736716029442 bayes_pls_golite062009
  • protein kinase activity
    		•  2.63659198898943 bayes_pls_golite062009
  • kinase activity
    		•  2.51764884377633 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.42131903112048 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  2.33489933634525 bayes_pls_golite062009
  • transferase activity
    		•  1.67087201309072 bayes_pls_golite062009
  • binding
    		•  1.59201750877601 bayes_pls_golite062009
  • protein kinase binding
    		•  1.55645492554893 bayes_pls_golite062009
  • kinase binding
    		•  1.51987207051111 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.48805696223451 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.42659032865959 bayes_pls_golite062009
  • protein binding
    		•  1.3720766721692 bayes_pls_golite062009
  • ion channel activity
    		•  1.14619697479951 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.11456280812043 bayes_pls_golite062009
  • channel activity
    		•  1.11456280812043 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.09419636675027 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.02079783694575 bayes_pls_golite062009
  • gated channel activity
    		•  0.86824333497311 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.808206044972536 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  0.49157430744145 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.44703917270274 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.40953951047033 bayes_pls_golite062009
  • enzyme binding
    		•  0.36894766018324 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.26231792801562 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.24227155451288 bayes_pls_golite062009
  • catalytic activity
    		•  0.181756622780318 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.17933752392049 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.17526760456624 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle