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Protein Overview: ort-PA

General Information:
Name(s) found: ort-PA / FBpp0083198 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene ora transientless is referred to in FlyBase by the symbol Dmel\ort (CG7411, FBgn0003011). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15485470..15489401. It has the cytological map location 92A13. Based on sequence similarity, it is predicted to have molecular function</span>: histamine-gated chloride channel activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; adult behavior; response to ether; response to toxin. 15 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; organ system; rhabdomere; cell projection; cell part; sensillum; rhabdomere R5. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 485 amino acids

    Gene Ontology:
    Cellular Component: histamine-gated chloride channel complex [NAS]
    postsynaptic membrane [IEA]
    integral to membrane [IEA]
    Biological Process: ion transport [IEA]
    response to ether [IMP]
    synaptic transmission [IMP]
    response to toxin [IMP]
    adult behavior [IMP]
    Molecular Function: histamine-gated chloride channel activity [ISS][NAS]
    extracellular ligand-gated ion channel activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFQIIILVI CTICMKHYAK GEFQQSLAIT DILPEDIKRY DKMRPPKKEG QPTIVYFHVT  60
   61 VMGLDSIDEN SMTYVADVFF AQTWKDHRLR LPENMTQEYR LLEVDWLKNM WRPDSFFKNA 120
  121 KSVTFQTMTI PNHYMWLYKD KTILYMVKLT LKLSCIMNFA IYPHDTQECK LQMESLSHTT 180
  181 DDLIFQWDPT TPLVVDENIE LPQVALIRNE TADCTQVYST GNFTCLEVVF TLKRRLVYYV 240
  241 FNTYIPTCMI VIMSWVSFWI KPEAAPARVT LGVTSLLTLS TQHAKSQSSL PPVSYLKAVD 300
  301 AFMSVCTVFV FMALMEYCLI NIVLSDTPIP KPMAYPPKPV AGDGPKKEGE GAPPGGSNST 360
  361 ASKQQATMLP LADEKIEKIE KIFDEMTKNR RIVTTTRRVV RPPLDADGPW IPRQESRIIL 420
  421 TPTIAPPPPP PQPAAPEPEL PKPKLTPAQE RLKRAIYIDR SSRVLFPALF ASLNGIYWCV 480
  481 FYEYL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..345] PSI-BLAST 63.154902 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [346..485] PSI-BLAST 35.69897 Acetylcholine receptor protein, gamma chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • gated channel activity
    		•  10.2551793466975 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  10.2376763289131 bayes_pls_golite062009
  • channel activity
    		•  10.2376763289131 bayes_pls_golite062009
  • cation channel activity
    		•  10.2347362632182 bayes_pls_golite062009
  • ion channel activity
    		•  10.2333303544163 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  10.0849981425464 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  9.75096408199907 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  9.75096408199907 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  9.54895878381443 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  8.93153903385632 bayes_pls_golite062009
  • acetylcholine binding
    		•  8.89748048814778 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  8.63094174477134 bayes_pls_golite062009
  • amine binding
    		•  7.31839282808397 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.38791849115967 bayes_pls_golite062009
  • neurotransmitter binding
    		•  4.25797760547212 bayes_pls_golite062009
  • receptor activity
    		•  4.1874951666279 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  4.14525491522551 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  4.06660325759774 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.04952633312337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.95647263626091 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.94320057935526 bayes_pls_golite062009
  • signal transducer activity
    		•  3.94320057935526 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.65985905824027 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.15685612471345 bayes_pls_golite062009
  • binding
    		•  2.05702964713174 bayes_pls_golite062009
  • beta-amyloid binding
    		•  2.05103642365448 bayes_pls_golite062009
  • transporter activity
    		•  1.77814143299132 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.70511083689232 bayes_pls_golite062009
  • drug binding
    		•  1.40945164171836 bayes_pls_golite062009
  • serotonin binding
    		•  1.33584589886834 bayes_pls_golite062009
  • serotonin-activated cation-selective channel activity
    		•  1.31324203158511 bayes_pls_golite062009
    		• 0.56308303460044 bayes_pls_golite062009
  • channel regulator activity
    		•  0.54858839706786 bayes_pls_golite062009
  • protein binding
    		•  0.387628241194027 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.302120334605641 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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