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Protein Overview: PP2A-B'-PC

General Information:
Name(s) found: PP2A-B'-PC / FBpp0082976 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene PP2A-B' is referred to in FlyBase by the symbol Dmel\PP2A-B' (CG7913, FBgn0042693). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13993451..14005771. It has the cytological map location 90F4-90F5. Based on sequence similarity, it is predicted to have molecular function</span>: protein phosphatase type 2A regulator activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid dephosphorylation. 23 alleles are reported. The phenotype of these alleles is annotated with: salivary gland. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 554 amino acids

    Gene Ontology:
    Cellular Component: protein phosphatase type 2A complex [IEA][ISS]
    Biological Process: neuromuscular junction development [IMP]
    anti-apoptosis [NAS]
    neuromuscular synaptic transmission [IMP]
    signal transduction [IEA]
    protein amino acid dephosphorylation [ISS]
    Molecular Function: protein phosphatase type 2A regulator activity [IEA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKDNQISVI YAPLQANKLK DNTPPYDAPP PTPISKVLNI TGTPIVRKEK RQTSARYNAS  60
   61 KNCELTALIP LNEKTAASER EELFIQKIQQ CCTLFDFSEP LSDLKFKEVK RAALHEMVDF 120
  121 LTNQNGVITE VIYPEAINMF AVNLFRTLPP SSNPNGAEFD PEEDEPTLES SWPHLQLVYE 180
  181 LFLRFLESPD FQPSMAKRFI DHQFVLQLLD LFDSEDPRER DFLKTVLHRI YGKFLGLRAF 240
  241 IRKQINNVFY RFIYETEHHN GIAELLEILG SIINGFALPL KEEHKQFLLK VLLPLHKAKS 300
  301 LSVYHPQLTY CVVQFLEKDP SLSEAVIKSL LKFWPKTHSP KEVMFLNELE ELLDVIEPAE 360
  361 FQKVMVPLFR QIAKCVSSPH FQVAERALYY WNNEYIMSLI TDNSAVILPI MFPALNRNSK 420
  421 THWNKTIHGL IYNALKLFME IDQRLFDECS KNYKQEKQME REKLSQREEL WQQVESLAKT 480
  481 NPEWTKARRF NDCLPVSDSR ALCDQYSENS DSAYDQSEQR ARQPPPPLPP QKQAHQEPRE 540
  541 VRQALATLTT LNNY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..554] PSI-BLAST 1000.0 No description for 2nppB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.41566231556356 bayes_pls_golite062009
  • phosphatase activity
    		•  6.2815295903206 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.23975872771765 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.04343158483355 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.13001603767079 bayes_pls_golite062009
  • protein phosphatase type 2A regulator activity
    		•  4.9046120881035 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  2.6399267580941 bayes_pls_golite062009
  • binding
    		•  2.6374633159018 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  2.60055057218296 bayes_pls_golite062009
  • hydrolase activity
    		•  1.97016752220053 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.549076739943715 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.135383662189061 bayes_pls_golite062009
  • kinase activity
    		•  0.133544629327977 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0343779350724151 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.00105949493785734 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle