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Protein Overview: Bin1-PA

General Information:
Name(s) found: Bin1-PA / FBpp0082731 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene Bicoid interacting protein 1 is referred to in FlyBase by the symbol Dmel\Bin1 (CG6046, FBgn0024491). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12011880..12012615. It has the cytological map location 89B7. There is experimental evidence that it has the molecular function</span>: protein binding; transcription factor binding; transcription corepressor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of gene-specific transcription; chromatin silencing; negative regulation of transcription, DNA-dependent. 11 alleles are reported. The phenotypes of these alleles are annotated with: larva; adult; adult abdominal segment 6; wing; adult abdominal segment; melanotic mass; embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 150 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    catalytic step 2 spliceosome [IDA]
    Sin3 complex [ISS]
    precatalytic spliceosome [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [NAS]
    negative regulation of transcription, DNA-dependent [IDA]
    negative regulation of gene-specific transcription [IGI]
    chromatin silencing [IGI]
    nuclear mRNA splicing, via spliceosome [IC]
    Molecular Function: protein binding [IPI]
    transcription corepressor activity [IGI][NAS]
    transcription factor binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANVESMIVE EKTQVKQIDR EKTCPMLLRV FCSTGRHHSV SEYMFGNVPT NELQIYTWQD  60
   61 ATLHELTSLV RDVNPDTRKK GTYFDFAVVY PNFRSNHFQM REIGVTCTGQ KGIDDNKTLA 120
  121 QAKFSIGDFL DISITPPNRL PPTARRQRPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] PSI-BLAST 59.30103 No description for 2hdeA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle