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Protein Overview: pnr-PA

General Information:
Name(s) found: pnr-PA / FBpp0082675 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene pannier is referred to in FlyBase by the symbol Dmel\pnr (CG3978, FBgn0003117). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11851819..11866639. It has the cytological map location 89A13-89B1. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: blastoderm segmentation; pigment metabolic process; heart contraction; dorsal closure; cardioblast cell fate determination; cardioblast differentiation; embryonic heart tube development; pericardial cell differentiation; cardiac cell differentiation; lymph gland development. 58 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; peripheral nervous system; nervous system; late extended germ band embryo; portion of tissue; embryonic/larval dorsal vessel; embryonic pericardial cell; anterior vertical bristle; embryonic nervous system; anterior orbital bristle; embryonic heart; imaginal precursor; external compound sense organ; lymph gland primordium; garland cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 540 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: dorsal closure [IMP][TAS]
    heart contraction [IMP]
    cardiac cell differentiation [IMP]
    blastoderm segmentation [IMP]
    transforming growth factor beta receptor signaling pathway [TAS]
    pigment metabolic process [IMP]
    mesoderm development [NAS]
    pattern specification process [NAS]
    cardioblast cell fate determination [IMP]
    regulation of transcription, DNA-dependent [IEA]
    ectoderm development [TAS]
    embryonic heart tube development [IMP]
    regulation of transcription [ISS]
    pericardial cell differentiation [IMP]
    heart development [TAS]
    bristle morphogenesis [TAS]
    negative regulation of transcription, DNA-dependent [TAS]
    positive regulation of transcription, DNA-dependent [NAS]
    lymph gland development [IMP]
    cell differentiation [NAS]
    cardioblast differentiation [IMP]
    Molecular Function: transcription factor activity [IEA][ISS][TAS]
    zinc ion binding [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGILLSDGDS TSDQQSTRDY PHFSGDYQNV TLSAASASTS ASASATHVAA VKMYHSSAVA  60
   61 AYTDLAAAGS AASAGVGVGV SGYHQQAVNA PVYVPSNRQY NHVAAHFGSA AAQNAWTTEG 120
  121 FGSAHAQFYS PNAAVMMGSW RSAYDPSGFQ RSSPYESAMD FQFGEGRECV NCGAISTPLW 180
  181 RRDGTGHYLC NACGLYHKMN GMNRPLIKPS KRLVSATATR RMGLCCTNCG TRTTTLWRRN 240
  241 NDGEPVCNAC GLYYKLHGVN RPLAMRKDGI QTRKRKPKKT GSGSAVGAGT GSGTGSTLEA 300
  301 IKECKEEHDL KPSLSLERHS LSKLHTDMKS GTSSSSTLMG HHSAQQQQQQ QQQQQQQQQQ 360
  361 QQQQSAHQQC FPLYGQTTTQ QQHQQHGHSM TSSSGQAHLS ARHLHGAAGT QLYTPGSSSG 420
  421 GGSASAYTSH SAETPALSNG TPSPHYQHHH HLGGTHGHHV TAAAAHHHFH AAAAVAAYGV 480
  481 KTEASATNYD YVNNCYFGGT FGALGGAATT TAMAGGAASE LAGYHHQHNV IQAAKLMATS 540
  541

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] MSA 1.155991 View MSA. No confident structure predictions are available.
    2 View Details [166..219] FFAS03 2.68 Erythroid transcription factor GATA-1
    3 View Details [220..282] PSI-BLAST 10.39794 Erythroid transcription factor GATA-1
    4 View Details [283..429] MSA 1.170991 View MSA. No confident structure predictions are available.
    5 View Details [430..540] MSA 7.162984 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.84932768708444 bayes_pls_golite062009
  • DNA binding
    		•  3.45124926204188 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.34875987514951 bayes_pls_golite062009
  • binding
    		•  2.8684204787273 bayes_pls_golite062009
  • transcription activator activity
    		•  2.7888666510808 bayes_pls_golite062009
  • transcription factor activity
    		•  2.74592237402384 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.5486735958299 bayes_pls_golite062009
  • protein binding
    		•  2.35367391992524 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.83119162033863 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.32499836066598 bayes_pls_golite062009
  • transcription factor binding
    		•  1.22761682002 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.1269808729848 bayes_pls_golite062009
  • receptor activity
    		•  0.910700236005457 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.449959641856445 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.446369866668139 bayes_pls_golite062009
  • catalytic activity
    		•  0.133319360419662 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.50210964370113 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • receptor activity
    		•  1.05205471090697 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.68270103300828 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle