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View Structure Prediction Details

Protein: pnr-PA
Organism: Drosophila melanogaster
Length: 540 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pnr-PA.

Description E-value Query
Range
Subject
Range
TCNA_TRYCR - Sialidase OS=Trypanosoma cruzi GN=TCNA PE=2 SV=1
191.0 [0..17] [539..599]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGILLSDGDS TSDQQSTRDY PHFSGDYQNV TLSAASASTS ASASATHVAA VKMYHSSAVA  60
   61 AYTDLAAAGS AASAGVGVGV SGYHQQAVNA PVYVPSNRQY NHVAAHFGSA AAQNAWTTEG 120
  121 FGSAHAQFYS PNAAVMMGSW RSAYDPSGFQ RSSPYESAMD FQFGE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRECVNCGAI STPLWRRDGT GHYLCNACGL YHKMNGMNRP LIKPSKRLVS ATAT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.68
Match: 2gatA
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.84932768708444 bayes_pls_golite062009
DNA binding 3.45124926204188 bayes_pls_golite062009
nucleic acid binding 3.34875987514951 bayes_pls_golite062009
binding 2.8684204787273 bayes_pls_golite062009
transcription activator activity 2.7888666510808 bayes_pls_golite062009
transcription factor activity 2.74592237402384 bayes_pls_golite062009
sequence-specific DNA binding 2.5486735958299 bayes_pls_golite062009
protein binding 2.35367391992524 bayes_pls_golite062009
transcription repressor activity 1.83119162033863 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.32499836066598 bayes_pls_golite062009
transcription factor binding 1.22761682002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.1269808729848 bayes_pls_golite062009
receptor activity 0.910700236005457 bayes_pls_golite062009
transcription cofactor activity 0.449959641856445 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.446369866668139 bayes_pls_golite062009
catalytic activity 0.133319360419662 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [220-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRMGLCCTNC GTRTTTLWRR NNDGEPVCNA CGLYYKLHGV NRPLAMRKDG IQTRKRKPKK  60
   61 TGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 2gatA
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.50210964370113 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
receptor activity 1.05205471090697 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.68270103300828 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [283-429]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSAVGAGTGS GTGSTLEAIK ECKEEHDLKP SLSLERHSLS KLHTDMKSGT SSSSTLMGHH  60
   61 SAQQQQQQQQ QQQQQQQQQQ QQSAHQQCFP LYGQTTTQQQ HQQHGHSMTS SSGQAHLSAR 120
  121 HLHGAAGTQL YTPGSSSGGG SASAYTS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [430-540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSAETPALSN GTPSPHYQHH HHLGGTHGHH VTAAAAHHHF HAAAAVAAYG VKTEASATNY  60
   61 DYVNNCYFGG TFGALGGAAT TTAMAGGAAS ELAGYHHQHN VIQAAKLMAT S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle